INT78062

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Context Info
Confidence 0.24
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.48
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1a, Il6) extracellular region (Il1a, Il6) cytosol (Il1a)
aging (Il6)
Anatomy Link Frequency
anterior pituitary 2
Il1a (Rattus norvegicus)
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 10 99.84 Very High Very High Very High
cytokine 22 81.84 Quite High
Inflammation 29 75.00 Quite High
cINOD 2 58.96 Quite High
antagonist 39 35.64 Quite Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
gABA 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 75.00 Quite High
Targeted Disruption 22 72.04 Quite High
Cytomegalovirus Infection 1 44.24 Quite Low
Stress 48 7.60 Low Low
Cancer 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Natriuresis 7 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DEX slightly inhibited IL-1-induced IL-6 release, while IL-1 releasing action on IL-6 was significantly reduced by IND.
IL-1-induced Positive_regulation (induced) of Localization (release) of IL-6 associated with dexamethasone
1) Confidence 0.24 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.32
To rule out the possibility that DEX was inhibiting LPS-induced IL-6 release by blocking IL-6 gene expression, we tested the effect of DEX on interleukin 1beta(IL-1)-induced IL-6 release.
IL-1 Positive_regulation (-induced) of Localization (release) of IL-6 associated with dexamethasone
2) Confidence 0.24 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.32
The production and release of IL-6 is stimulated by IL-1 in rat anterior pituitary cells in vitro (702) and IL-1 and IL-6 act synergistically in stimulating ACTH secretion in vivo (703).
IL-1 Positive_regulation (stimulated) of Localization (release) of IL-6 in anterior pituitary
3) Confidence 0.00 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.33 Pain Relevance 0.26

General Comments

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