INT78066

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Context Info
Confidence 0.03
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.76
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) signal transduction (Tlr4) aging (Il6)
extracellular region (Il6) plasma membrane (Tlr4) intracellular (Tlr4)
Anatomy Link Frequency
astrocytes 4
pituitary 2
Tlr4 (Mus musculus)
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 20 99.68 Very High Very High Very High
cytokine 44 95.60 Very High Very High Very High
Inflammation 58 87.60 High High
cINOD 4 82.32 Quite High
antagonist 78 28.72 Quite Low
Nerve growth factor 56 5.00 Very Low Very Low Very Low
agonist 44 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 34 5.00 Very Low Very Low Very Low
substance P 32 5.00 Very Low Very Low Very Low
gABA 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 64 87.60 High High
Targeted Disruption 44 71.12 Quite High
Cytomegalovirus Infection 2 58.00 Quite High
Stress 96 54.12 Quite High
Cancer 44 5.60 Low Low
Pituitary Cancer 22 5.00 Very Low Very Low Very Low
Starvation 20 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 16 5.00 Very Low Very Low Very Low
Natriuresis 14 5.00 Very Low Very Low Very Low
Adhesions 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPS stimulated IL-6 release in a concentration-dependent manner from rat cortical type I astrocytes.
LPS Positive_regulation (stimulated) of Localization (release) of IL-6 in astrocytes
1) Confidence 0.03 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.21
We found that L-NO-arginine, an inhibitor of nitric oxide synthase, concentration-dependently reduced LPS-induced IL-6 release in astrocytes.
LPS Positive_regulation (induced) of Localization (release) of IL-6 in astrocytes
2) Confidence 0.03 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.32
LPS-induced IL-6 release was partially inhibited by BW 4AC, a 5-lipoxygenase inhibitor.
LPS Positive_regulation (induced) of Localization (release) of IL-6
3) Confidence 0.03 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.25
To rule out the possibility that DEX was inhibiting LPS-induced IL-6 release by blocking IL-6 gene expression, we tested the effect of DEX on interleukin 1beta(IL-1)-induced IL-6 release.
LPS Positive_regulation (induced) of Localization (release) of IL-6 associated with dexamethasone
4) Confidence 0.03 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.27
Although LPS stimulates IL-6 secretion in monolayer as well as in mouse pituitary cell aggregates, LPS can stimulate ACTH secretion only in aggregates (700).
LPS Positive_regulation (stimulates) of Localization (secretion) of IL-6 in pituitary
5) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.05 Pain Relevance 0
Also LPS directly stimulates IL-6 release from FS cells (701).
LPS Positive_regulation (stimulates) of Localization (release) of IL-6
6) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.41 Pain Relevance 0.21

General Comments

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