INT78097

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.02
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
skin 2
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 3 100.00 Very High Very High Very High
qutenza 12 99.30 Very High Very High Very High
substance P 3 94.56 High High
Pain 3 90.08 High High
Analgesic 1 73.88 Quite High
palliative 1 5.00 Very Low Very Low Very Low
Somatostatin 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 88 100.00 Very High Very High Very High
Cancer 34 95.04 Very High Very High Very High
Carcinoid 1 94.76 High High
Small Cell Lung Cancer 1 94.28 High High
Lung Cancer 1 94.04 High High
Pain 2 90.08 High High
Apoptosis 2 89.16 High High
Renal Cancer 1 83.08 Quite High
Non-small-cell Lung Cancer 2 81.76 Quite High
Syndrome 3 67.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was nearly complete degeneration of epidermal nerve fibers and the subepidermal neural plexus in capsaicin-treated skin, as indicated by the loss of immunoreactivity for PGP 9.5 and CGRP.
Negative_regulation (loss) of Regulation (immunoreactivity) of CGRP in skin associated with qutenza and calcitonin gene-related peptide
1) Confidence 0.42 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9787000 Disease Relevance 0.24 Pain Relevance 1.37
In recent studies, we have shown that activation of doxycycline-inducible Notch1 in MTC cells significantly reduced MTC cellular growth and regulated calcitonin level in a dose-dependent fashion; furthermore, these changes were dependent on the amount of Notch1 protein [35].
Negative_regulation (reduced) of Regulation (regulated) of calcitonin associated with thyroid neoplasm
2) Confidence 0.10 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.78 Pain Relevance 0

General Comments

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