INT78116

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 10.78
Pain Relevance 4.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
neuronal 8
spinal cords 4
liver 2
App (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Abeta 30 100.00 Very High Very High Very High
Inflammation 45 99.04 Very High Very High Very High
sSRI 96 94.92 High High
cINOD 21 93.88 High High
agonist 3 91.08 High High
adenocard 4 90.28 High High
rheumatoid arthritis 4 85.88 High High
Inflammatory response 4 75.12 Quite High
Analgesic 4 73.88 Quite High
cytokine 5 66.92 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 30 100.00 Very High Very High Very High
Encephalitis 2 99.04 Very High Very High Very High
Insulin Resistance 16 98.36 Very High Very High Very High
Injury 9 97.88 Very High Very High Very High
INFLAMMATION 57 97.08 Very High Very High Very High
Disease 153 96.20 Very High Very High Very High
Pressure And Volume Under Development 52 96.20 Very High Very High Very High
Hyperlipidemia 2 95.52 Very High Very High Very High
Stress 10 94.36 High High
Drug Induced Neurotoxicity 2 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both mercury and lead increase the expression of the amyloid precursor protein; mercury also stimulates the formation of insoluble beta-amyloid, which plays a crucial role in the pathogenesis of AD and causes oxidative stress and neurotoxicity in vitro.
Positive_regulation (increase) of Gene_expression (expression) of amyloid precursor protein associated with stress, drug induced neurotoxicity, alzheimer's dementia and disease
1) Confidence 0.70 Published 2006 Journal Rev Environ Health Section Abstract Doc Link 16898674 Disease Relevance 1.31 Pain Relevance 0.18
After distal axotomy, without apparent neurodegeneration such as cell loss and decreased ChaT-immunoreactivity, increased levels of APP expression were observed in the spinal cords of aged rats post-injury.
Positive_regulation (increased) of Gene_expression (expression) of APP in spinal cords associated with injury
2) Confidence 0.68 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898540 Disease Relevance 0.50 Pain Relevance 0
We found that mefenamic acid attenuates the neurotoxicities induced by amyloid beta peptide (Abeta)(1-42) treatment and the expression of a Swedish double mutation (KM595/596NL) of amyloid precursor protein (Swe-APP) or the C-terminal fragments of APP (APP-CTs) in neuronal cells.
Positive_regulation (induced) of Gene_expression (expression) of APP in neuronal associated with alzheimer's dementia and abeta
3) Confidence 0.50 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16223958 Disease Relevance 0.99 Pain Relevance 0.65
We found that mefenamic acid attenuates the neurotoxicities induced by amyloid beta peptide (Abeta)(1-42) treatment and the expression of a Swedish double mutation (KM595/596NL) of amyloid precursor protein (Swe-APP) or the C-terminal fragments of APP (APP-CTs) in neuronal cells.
Positive_regulation (induced) of Gene_expression (expression) of APP-CTs in neuronal associated with alzheimer's dementia and abeta
4) Confidence 0.50 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16223958 Disease Relevance 0.99 Pain Relevance 0.65
We found that mefenamic acid attenuates the neurotoxicities induced by amyloid beta peptide (Abeta)(1-42) treatment and the expression of a Swedish double mutation (KM595/596NL) of amyloid precursor protein (Swe-APP) or the C-terminal fragments of APP (APP-CTs) in neuronal cells.
Positive_regulation (induced) of Gene_expression (expression) of APP in neuronal associated with alzheimer's dementia and abeta
5) Confidence 0.50 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16223958 Disease Relevance 0.98 Pain Relevance 0.65
We found that mefenamic acid attenuates the neurotoxicities induced by amyloid beta peptide (Abeta)(1-42) treatment and the expression of a Swedish double mutation (KM595/596NL) of amyloid precursor protein (Swe-APP) or the C-terminal fragments of APP (APP-CTs) in neuronal cells.
Positive_regulation (induced) of Gene_expression (expression) of amyloid precursor protein in neuronal associated with alzheimer's dementia and abeta
6) Confidence 0.50 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16223958 Disease Relevance 0.98 Pain Relevance 0.65
After distal axotomy, without apparent neurodegeneration such as cell loss and decreased ChaT-immunoreactivity, increased levels of APP expression were observed in the spinal cords of aged rats post-injury.
Positive_regulation (levels) of Gene_expression (expression) of APP in spinal cords associated with injury
7) Confidence 0.46 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898540 Disease Relevance 0.50 Pain Relevance 0
Increases in the level of Abeta in NB cells following an elevation of intracellular cAMP levels appear to be due to an increase in the rate of processing of the amyloid precursor protein (APP) rather than an increase in the expression of APP.
Positive_regulation (increase) of Gene_expression (expression) of APP associated with alzheimer's dementia and abeta
8) Confidence 0.44 Published 1998 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 9790168 Disease Relevance 0.67 Pain Relevance 0.44
Increases in the level of Abeta in NB cells following an elevation of intracellular cAMP levels appear to be due to an increase in the rate of processing of the amyloid precursor protein (APP) rather than an increase in the expression of APP.
Positive_regulation (increase) of Gene_expression (processing) of amyloid precursor protein associated with alzheimer's dementia and abeta
9) Confidence 0.31 Published 1998 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 9790168 Disease Relevance 0.74 Pain Relevance 0.40
Increases in the level of Abeta in NB cells following an elevation of intracellular cAMP levels appear to be due to an increase in the rate of processing of the amyloid precursor protein (APP) rather than an increase in the expression of APP.
Positive_regulation (increase) of Gene_expression (processing) of APP associated with alzheimer's dementia and abeta
10) Confidence 0.31 Published 1998 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 9790168 Disease Relevance 0.74 Pain Relevance 0.40
Morse et al (2003) and Payton et al (2004) have screened drugs for their ability to stimulate expression of the APP ectodomain.
Positive_regulation (stimulate) of Gene_expression (expression) of APP
11) Confidence 0.20 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656299 Disease Relevance 0.64 Pain Relevance 0.26
In addition, the liver increases the synthesis of Acute Phase Proteins (APP), including LPS binding protein (LBP), whose serum levels are markedly increased in rats with PH.
Positive_regulation (increases) of Gene_expression (synthesis) of APP in liver associated with pressure and volume under development
12) Confidence 0.19 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2262079 Disease Relevance 1.74 Pain Relevance 0.24

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