INT78117

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Context Info
Confidence 0.48
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.60
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
brain 2
reticulum 2
App (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 9 100.00 Very High Very High Very High
Hippocampus 27 84.96 Quite High
adenocard 1 78.32 Quite High
cINOD 3 67.76 Quite High
Inflammation 4 52.44 Quite High
cytokine 1 45.48 Quite Low
Enkephalin 1 25.00 Low Low
Eae 12 5.00 Very Low Very Low Very Low
long-term potentiation 7 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 31 100.00 Very High Very High Very High
Disease 199 99.34 Very High Very High Very High
Dementia 9 91.52 High High
Neurodegenerative Disease 25 90.96 High High
Death 11 75.76 Quite High
Neuroblastoma 11 74.72 Quite High
Amyloid Plaque 17 66.88 Quite High
INFLAMMATION 5 66.32 Quite High
Cognitive Disorder 57 46.72 Quite Low
Adhesions 1 46.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A small and not significant, but clear increase in accumulation of APP-CTFs and holoAPP was associated with increased extracellular accumulation of sAPP?
Neg (not) Positive_regulation (increase) of Positive_regulation (accumulation) of APP
1) Confidence 0.48 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2806870 Disease Relevance 0.15 Pain Relevance 0
The neurotoxic effects of APP are believed to be mediated by proteolytic processing of APP which gives rise to A?
Positive_regulation (mediated) of Positive_regulation (effects) of APP
2) Confidence 0.47 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.59 Pain Relevance 0
We previously reported that homocysteic acid (HA) may be one of the pathological biomarkers in the brain with AD and that the increased levels of HA may induce the accumulation of intraneuronal amyloid-beta (A?)
Spec (may) Positive_regulation (induce) of Positive_regulation (accumulation) of amyloid-beta in brain associated with alzheimer's dementia and disease
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808336 Disease Relevance 0.89 Pain Relevance 0.04
We postulate that PG-induced elevation of Abeta may lead to an increased binding of Abeta to the 20S proteasome, resulting in a reduction of 20S proteasome-mediated degradation of ubiquitin-conjugated proteins.
Positive_regulation (induced) of Positive_regulation (elevation) of Abeta associated with abeta
4) Confidence 0.21 Published 1998 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 9790168 Disease Relevance 0.60 Pain Relevance 0.40
To identify the subcellular compartment(s) in which familial Alzheimer's disease mutant PS2 (mt PS2) affects the gamma-cleavage of betaAPP to increase Abeta42, we co-expressed the C-terminal 99-amino acid fragment of betaAPP (C100) tagged with sorting signals to the endoplasmic reticulum (C100/ER) or to the trans-Golgi network (C100/TGN) together with mt PS2 in N2a cells.
Positive_regulation (gamma-cleavage) of Positive_regulation (increase) of betaAPP in reticulum associated with disease
5) Confidence 0.16 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11283011 Disease Relevance 0.36 Pain Relevance 0.07

General Comments

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