INT7812

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.28
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SRI) transport (SRI) plasma membrane (SRI)
intracellular (SRI) cytoplasm (SRI)
Anatomy Link Frequency
SCN 3
neuronal 1
pineal gland 1
SRI (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 7 98.54 Very High Very High Very High
Glutamate 3 91.60 High High
Serotonin 10 86.56 High High
agonist 23 79.44 Quite High
anesthesia 3 78.80 Quite High
gABA 1 75.64 Quite High
Neuropeptide 5 75.00 Quite High
tetrodotoxin 1 71.36 Quite High
Raphe 2 68.00 Quite High
midbrain 1 67.76 Quite High
Disease Link Frequency Relevance Heat
Impulse Control Disorders 118 99.76 Very High Very High Very High
Disease 115 99.28 Very High Very High Very High
Calcification 2 98.52 Very High Very High Very High
Aging 12 98.30 Very High Very High Very High
Dementia 273 95.52 Very High Very High Very High
Anxiety Disorder 141 91.20 High High
Sleep Initiation And Maintenance Disorders 104 68.44 Quite High
Heart Rate Under Development 9 60.16 Quite High
Sleep Disorders 60 60.04 Quite High
Ganglion Cysts 1 59.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is unclear if disturbed rhythms are the result of decreased SCN activity, environmental cues, or a combination of both.
Negative_regulation (decreased) of SCN
1) Confidence 0.59 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413196 Disease Relevance 0.21 Pain Relevance 0
For everyone else the output of the SCN declines, producing a poorer circadian rhythm with a peak that becomes gradually later in the day.
Negative_regulation (declines) of SCN
2) Confidence 0.38 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413196 Disease Relevance 0.71 Pain Relevance 0
At the cellular level, there is a decrease in the activity of individual neurons within the SCN in patients with AD (Hoogendijk et al 1996).
Negative_regulation (decrease) of SCN in SCN associated with disease
3) Confidence 0.38 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413196 Disease Relevance 0.72 Pain Relevance 0.08
The high uptake of 2-DG in the SCN during the daytime was inhibited by the superfusion of 8-OH-DPAT, muscimol, flurazepam and pentobarbital in a dose-dependent manner, but the low uptake of 2-DG during the night was unaffected.
Negative_regulation (inhibited) of SCN in SCN
4) Confidence 0.37 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1356802 Disease Relevance 0 Pain Relevance 0.19
Further, there is loss of expression of AVP and MT1 receptors in the SCN.
Negative_regulation (loss) of SCN
5) Confidence 0.16 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2939436 Disease Relevance 0.50 Pain Relevance 0.11
There is a great deal of evidence indicating that aging is characterized by a progressive deterioration of circadian timekeeping, including loss of SCN melatonin receptors [14,42-44].
Negative_regulation (loss) of SCN associated with aging
6) Confidence 0.13 Published 2010 Journal BMC Med Section Body Doc Link PMC2933606 Disease Relevance 0.23 Pain Relevance 0.03
Endogenous melatonin levels decrease with age, presumably due to an age-related decline in SCN circadian rhythmic functions or the calcification of the pineal gland [11-18].
Negative_regulation (decline) of SCN in pineal gland associated with calcification
7) Confidence 0.12 Published 2010 Journal BMC Med Section Body Doc Link PMC2933606 Disease Relevance 0.40 Pain Relevance 0
While phase shifting and neuronal suppression in the SCN represent a basis of hypnotic actions of all melatoninergic drugs, sleep research literature frequently ignores the fact that the membrane-bound melatonin receptors are not restricted to the SCN.
Negative_regulation (suppression) of SCN in neuronal
8) Confidence 0.09 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2699659 Disease Relevance 0 Pain Relevance 0.18
Anecdotal evidence also suggests that the effectiveness of SRI's in TTM may wane with time [71].
Negative_regulation (effectiveness) of SRI associated with impulse control disorders
9) Confidence 0.03 Published 2005 Journal BMC Psychiatry Section Body Doc Link PMC546013 Disease Relevance 1.12 Pain Relevance 0.09
However, receptor autoradiographic studies showed that fluoxetine prevents the age-related increase in SCN 5-HT(1B) receptors at ZT6, and decreases SCN 5-HT(1B) receptors in both ages at ZT13.
Negative_regulation (decreases) of SCN in SCN associated with fluoxetine
10) Confidence 0.02 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525077 Disease Relevance 0.38 Pain Relevance 0.79

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