INT7813

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Context Info
Confidence 0.61
First Reported 1992
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 6.18
Pain Relevance 8.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SRI) transport (SRI) plasma membrane (SRI)
intracellular (SRI) cytoplasm (SRI)
Anatomy Link Frequency
SCN 6
neurons 3
thalamus 2
optic nerve 2
hypothalamus 1
SRI (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 24 100.00 Very High Very High Very High
opioid receptor 13 99.98 Very High Very High Very High
Serotonin 35 99.90 Very High Very High Very High
Thalamus 11 99.88 Very High Very High Very High
5HT 23 99.38 Very High Very High Very High
Calcium channel 5 98.90 Very High Very High Very High
Opioid 33 98.60 Very High Very High Very High
agonist 28 98.48 Very High Very High Very High
Delta opioid receptors 4 96.44 Very High Very High Very High
Enkephalin 9 94.32 High High
Disease Link Frequency Relevance Heat
Aging 15 99.98 Very High Very High Very High
Tics 26 99.90 Very High Very High Very High
Anxiety Disorder 35 99.84 Very High Very High Very High
Tourette's Syndrome 4 90.52 High High
Dizziness 11 90.24 High High
Headache 14 89.68 High High
Temporomandibular Joint Syndrome 4 88.08 High High
Sleep Disorders 64 86.04 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 82.72 Quite High
Depression 55 79.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results strongly suggest that agonists of 5-HT1A receptors and GABAA-benzodiazepine-barbiturate complex receptors regulate the function of the SCN through their inhibitory action on 2-DG uptake during the day, and that glutamate also regulates SCN function through it stimulatory action on 2-DG uptake during the night.
Regulation (regulates) of SCN in SCN associated with glutamate and agonist
1) Confidence 0.61 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1356802 Disease Relevance 0 Pain Relevance 0.26
Additional data are needed on how comorbid tics may affect SRI treatment response in OCD.
Spec (may) Regulation (affect) of SRI associated with tics and anxiety disorder
2) Confidence 0.60 Published 2007 Journal J Psychiatr Res Section Abstract Doc Link 16860338 Disease Relevance 1.55 Pain Relevance 0.46
-opioid receptor agonist fentanyl induces a phase shift in the circadian rhythm of hamsters independent of any behavioral effects of the opioid.8,9 We showed previously that fentanyl modifies the circadian pacemaker possibly via direct effects on SCN electrical activity and regulation of Per genes.8 This suggests that pathways regulating the circadian clock intersect directly or indirectly with pathways that express opioid receptors.
Regulation (regulation) of SCN associated with agonist, opioid receptor and opioid
3) Confidence 0.28 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004635 Disease Relevance 0 Pain Relevance 0.85
Additional data are needed on how comorbid tics may affect SRI treatment response in OCD.
Regulation (response) of SRI associated with tics and anxiety disorder
4) Confidence 0.26 Published 2007 Journal J Psychiatr Res Section Abstract Doc Link 16860338 Disease Relevance 1.50 Pain Relevance 0.46
The present results strongly suggest that agonists of 5-HT1A receptors and GABAA-benzodiazepine-barbiturate complex receptors regulate the function of the SCN through their inhibitory action on 2-DG uptake during the day, and that glutamate also regulates SCN function through it stimulatory action on 2-DG uptake during the night.
Regulation (regulate) of SCN in SCN associated with glutamate and agonist
5) Confidence 0.23 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1356802 Disease Relevance 0 Pain Relevance 0.27
Abnormal responsiveness of SCN was discovered.
Regulation (responsiveness) of SCN in SCN
6) Confidence 0.18 Published 1993 Journal Zh Nevrol Psikhiatr Im S S Korsakova Section Abstract Doc Link 8160507 Disease Relevance 0.51 Pain Relevance 0.64
Specifically, we found that (1) there were daily variations in the extracellular concentrations of 5-hydroxyindoleacetic acid (5-HIAA) and glutamate (GLU) in the SCN region (highest levels of 5-HIAA occurred soon after lights-off, whereas GLU peaked later in the dark phase); (2) the daily rhythm of GLU, but not serotonin, in the SCN region appeared to be circadian in nature and was not driven by an external influence; (3) the rhythm in GLU measured in SCN microdialysate involved a tetrodotoxin-insensitive mechanism and did not appear to be directly linked to the expression of locomotor behavior; and (4) direct application of serotonin receptor agonists via the microdialysis probe suppressed the concentration of extracellular GLU in the SCN region, suggesting that serotonin may modulate GLU release in the SCN.
Regulation (modulate) of SCN in external associated with tetrodotoxin, glutamate, agonist and serotonin
7) Confidence 0.14 Published 1993 Journal J. Biol. Rhythms Section Abstract Doc Link 7506085 Disease Relevance 0 Pain Relevance 0.67
Apart from the thalamocortical interplay, which is necessary for spindle formation, the thalamus also influences the SCN.
Regulation (influences) of SCN in thalamus associated with thalamus
8) Confidence 0.13 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2699659 Disease Relevance 0 Pain Relevance 0.13
The central internal (endogenous) circadian rhythm pacemaker (regulating such 24-hour biological cycles as endocrine function and body temperature) is located in the suprachiasmatic nucleus (SCN) of the hypothalamus.31 Light influences SCN function via a neural pathway from the retina to the SCN.
Regulation (influences) of SCN in hypothalamus
9) Confidence 0.13 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785860 Disease Relevance 0.39 Pain Relevance 0.15
The activity of the SCN is regulated by environmental signals in a 24-hour cycle and runs autonomously.
Regulation (regulated) of SCN in SCN
10) Confidence 0.10 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2939436 Disease Relevance 0.43 Pain Relevance 0.06
The authors became interested in the possibility that 5HT can inhibit the glutamatergic regulation of Ca2+ in SCN neurons and, by this mechanism, modulate light-induced phase shifts of the circadian system.
Regulation (regulation) of SCN in neurons associated with 5ht
11) Confidence 0.10 Published 1999 Journal J. Biol. Rhythms Section Abstract Doc Link 10511003 Disease Relevance 0 Pain Relevance 0.40
Which orthologs of genes that undergo temporal regulation in hSkM also undergo circadian regulation in mouse skeletal muscle (mSkM), liver (mLvr), heart (mHrt) or SCN (mSCN)?
Regulation (regulation) of SCN in liver
12) Confidence 0.06 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0.07
Therefore, in the present study, we examined the distribution of delta opioid receptor immunoreactivity in the hamster SCN and the IGL of the thalamus.
Spec (examined) Regulation (immunoreactivity) of SCN in thalamus associated with thalamus and opioid receptor
13) Confidence 0.05 Published 2000 Journal Brain Res. Section Abstract Doc Link 10700547 Disease Relevance 0 Pain Relevance 0.65
However, given what is known about the role of Rrad in other systems, increased Rrad protein would also serve to downregulate the response of SCN cells to subsequent stimulation.
Regulation (response) of SCN
14) Confidence 0.03 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0.05 Pain Relevance 0.04
Increased Rrad expression is associated with the removal of voltage-gated calcium channels from the plasma membrane [32], which would reduce the response of SCN neurons to excitatory stimuli.
Regulation (response) of SCN in neurons associated with calcium channel
15) Confidence 0.03 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0.07 Pain Relevance 0.05
However, this rhythm could not be entrained to a new light cycle after the optic nerve was severed, suggesting that some component of the circadian regulation of disc shedding may be under the control of the SCN [13].
Regulation (control) of SCN in optic nerve
16) Confidence 0.03 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3000237 Disease Relevance 0 Pain Relevance 0.04
However, under certain conditions (such as restricted feeding), peripheral tissue clocks can be regulated independently of the SCN [22,23].
Neg (independently) Regulation (regulated) of SCN in SCN
17) Confidence 0.03 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0.09
However, it is important to mention that these data do not define the contribution of the SCN to the regulation of the circadian rhythms in the RPE in vivo.
Regulation (contribution) of SCN
18) Confidence 0.02 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3000237 Disease Relevance 0 Pain Relevance 0.03
The induction of Tiparp provides another potential mechanism for altering clock function, although the targets for ribosylation in the SCN are unknown.
Regulation (targets) of SCN
19) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0.12 Pain Relevance 0.07
An increase in functional MKP1 would reduce the sensitivity of the SCN to photic stimuli, and shut down the transcriptional mechanisms turned on by light.
Regulation (sensitivity) of SCN
20) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0 Pain Relevance 0.03

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