INT78144

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Context Info
Confidence 0.72
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.21
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (AKR1C3) intracellular (AKR1C3) cytoplasm (AKR1C3)
Anatomy Link Frequency
mammary gland 2
AKR1C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 65.20 Quite High
antagonist 1 47.24 Quite Low
Potency 1 25.00 Low Low
ischemia 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 55 94.96 High High
Prostate Cancer 55 84.20 Quite High
Cancer 105 79.76 Quite High
Reprotox - General 1 2 78.80 Quite High
Breast Cancer 26 77.44 Quite High
Endometriosis (extended) 1 75.92 Quite High
INFLAMMATION 2 65.00 Quite High
Adhesions 14 42.64 Quite Low
Disease 5 37.76 Quite Low
Carcinoma 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Relatively high mRNA expression of AKR1C3 was found in human prostate and mammary gland where it is implicated in regulating ligand access to the androgen and estrogen receptor, respectively.
Transcription (expression) of AKR1C3 in mammary gland
1) Confidence 0.72 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19007764 Disease Relevance 0.37 Pain Relevance 0.06
Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.
Transcription (species) of AKR1C3
2) Confidence 0.69 Published 1998 Journal J. Biochem. Section Title Doc Link 9792917 Disease Relevance 0.07 Pain Relevance 0.07
The expression of AKR1C1, AKR1C2 and AKR1C3 mRNAs has been detected in human mammary gland [24,27-29].
Transcription (expression) of AKR1C3 in mammary gland
3) Confidence 0.51 Published 2004 Journal BMC Cancer Section Body Doc Link PMC459223 Disease Relevance 0.11 Pain Relevance 0
However, in contrast to their findings, transcripts for AKR1C3, SRD5A1, HSD3B2, AKR1C2, AKR1C1 are not consistently upregulated in the metastatic samples in our study.
Transcription (transcripts) of AKR1C3
4) Confidence 0.38 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.66 Pain Relevance 0

General Comments

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