INT7817

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Context Info
Confidence 0.19
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.26
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP1) peptidase activity (CASP1) signal transduction (CASP1)
intracellular (CASP1) cytoplasm (CASP1)
Anatomy Link Frequency
macrophages 1
spinal cord 1
CASP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 5 100.00 Very High Very High Very High
Dynorphin 3 100.00 Very High Very High Very High
Spinal cord 2 99.60 Very High Very High Very High
Opioid 2 96.48 Very High Very High Very High
Inflammation 35 88.96 High High
cytokine 40 87.20 High High
Inflammatory stimuli 4 73.16 Quite High
Delta opioid receptors 1 65.60 Quite High
addiction 4 18.48 Low Low
chemokine 2 9.68 Low Low
Disease Link Frequency Relevance Heat
Death 7 95.76 Very High Very High Very High
INFLAMMATION 43 88.96 High High
Apoptosis 146 82.88 Quite High
Influenza Virus Infection 67 81.88 Quite High
Repression 4 80.64 Quite High
Viral Infection 2 79.68 Quite High
Infection 35 66.96 Quite High
Toxicity 3 50.16 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 36.32 Quite Low
Aging 2 28.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Membranes were blocked in Tween-Tris-buffered saline (TTBS) containing 5% nonfat milk and were incubated with antibodies that recognized caspase-1 p10 (rabbit polyclonal sc-515; Santa Cruz Biotechnology, Santa Cruz, CA), p-I?
caspase-1 Binding (recognized) of
1) Confidence 0.19 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
Characterization of dynorphin A-converting enzyme in human spinal cord.
A-converting enzyme Binding (Characterization) of in spinal cord associated with dynorphin, enkephalin and spinal cord
2) Confidence 0.17 Published 1992 Journal J. Biol. Chem. Section Title Doc Link 1356987 Disease Relevance 0 Pain Relevance 0.86
Upon sensing these ligands, protein interactions among domains of NLRs, the adaptor protein ASC, and Caspase-1 (a cysteine protease) ultimately form the multi-protein inflammasome structure.
Caspase-1 Binding (interactions) of
3) Confidence 0.05 Published 2009 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2794489 Disease Relevance 0.29 Pain Relevance 0.04
The 10panx1 peptide did not inhibit caspase-1 activity per se in cell-free assays, so ruling out a direct chemical or enzymatic interaction with caspase-1.
caspase-1 Binding (interaction) of
4) Confidence 0.03 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.13 Pain Relevance 0.08
release but also in all caspase-1 associated signaling through the NLRP3 inflammasome [40, 42, 56].
caspase-1 Binding (associated) of
5) Confidence 0.03 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.14 Pain Relevance 0.10
The Shigella effector IpaB binds and activates caspase-1 in macrophages, leading to IL-1?
caspase-1 Binding (binds) of in macrophages
6) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.70 Pain Relevance 0.04
For example, a ligand designed to bind to the homodimeric interface of caspase-1 was found to exert allosteric control over the distal catalytic site [46].
caspase-1 Binding (bind) of
7) Confidence 0.01 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816688 Disease Relevance 0 Pain Relevance 0

General Comments

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