INT78177

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.04
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Ednrb) aging (Ednrb) plasma membrane (Ednrb)
signal transducer activity (Ednrb)
Anatomy Link Frequency
eye 2
skin 2
Ednrb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 17 100.00 Very High Very High Very High
mu opioid receptor 2 100.00 Very High Very High Very High
Morphine 13 97.36 Very High Very High Very High
analgesia 6 97.36 Very High Very High Very High
medulla 3 96.88 Very High Very High Very High
anesthesia 1 82.36 Quite High
tolerance 4 75.12 Quite High
Opioid 3 75.00 Quite High
Pain 3 12.96 Low Low
Calcium channel 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 17 99.40 Very High Very High Very High
Pulmonary Hypertension 106 91.28 High High
Pulmonary Disease 3 74.24 Quite High
Disease 11 59.68 Quite High
Diabetic Retinopathy 1 58.68 Quite High
Nociception 2 58.48 Quite High
Eye Disease 1 55.12 Quite High
Infection 2 39.68 Quite Low
Peripheral Arterial Disease 5 29.28 Quite Low
Apoptosis 4 28.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result, the expressions of ETA and ETB receptors are reduced with both immunostaining and the mRNA levels in the left eye, in which endothelin-1 eyedrops were applied at 4 x 10(-5) M.
Negative_regulation (reduced) of Gene_expression (expressions) of ETB in eye
1) Confidence 0.41 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15838338 Disease Relevance 0.17 Pain Relevance 0.08
Recent research investigating the role of vasoactive intestinal peptide (VIP) in rats has produced promising results.110 This study showed that ETA antagonists, ETB antagonists, and VIP all prevented the pulmonary vasoconstriction caused by ET1.
Negative_regulation (prevented) of Gene_expression (antagonists) of ETB associated with antagonist and increased venous pressure under development
2) Confidence 0.23 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697585 Disease Relevance 0.81 Pain Relevance 0.19
In males, exposure to endothelin-1 decreased mu opioid receptor expression without changing endothelin-A receptor or endothelin-B receptor expression in the hindpaw skin.
Negative_regulation (decreased) of Gene_expression (expression) of endothelin-B receptor in skin associated with mu opioid receptor
3) Confidence 0.21 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19788914 Disease Relevance 0.06 Pain Relevance 1.22
In contrast, there was a threefold (p < 0.0001) downregulation of the ETB receptor mRNA expression.
Negative_regulation (downregulation) of Gene_expression (expression) of ETB receptor mRNA
4) Confidence 0.01 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9795754 Disease Relevance 0 Pain Relevance 0.67

General Comments

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