INT78190

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 18
Disease Relevance 21.23
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnc) extracellular space (Tnc) extracellular region (Tnc)
cell adhesion (Tnc) proteinaceous extracellular matrix (Tnc)
Anatomy Link Frequency
astrocytes 1
tooth 1
Tnc (Mus musculus)
Pain Link Frequency Relevance Heat
antiepileptic Drug 27 99.54 Very High Very High Very High
antagonist 22 98.16 Very High Very High Very High
carbamazepine 108 97.84 Very High Very High Very High
Lamotrigine 54 96.08 Very High Very High Very High
fluoxetine 1 95.92 Very High Very High Very High
Chronic pancreatitis 37 95.28 Very High Very High Very High
cytokine 118 92.72 High High
fibrosis 9 89.20 High High
Central nervous system 6 87.28 High High
cINOD 45 85.64 High High
Disease Link Frequency Relevance Heat
Staphylococcus Infection 1152 100.00 Very High Very High Very High
Bullous Skin Disease 954 100.00 Very High Very High Very High
Cancer 213 100.00 Very High Very High Very High
Pancreatic Cancer 4 99.84 Very High Very High Very High
Infection 155 99.32 Very High Very High Very High
Disease 229 99.14 Very High Very High Very High
Injury 73 99.00 Very High Very High Very High
Malignant Neoplastic Disease 15 98.98 Very High Very High Very High
Sprains And Strains 130 97.92 Very High Very High Very High
Blister 99 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the increased expression of collagen V–a collagen type that has been shown to accumulate in malignant disease [40]–and the more diffuse distribution of Tenascin C–an ECM protein that is overexpressed in pancreatic cancer [41]–and of ?
Gene_expression (overexpressed) of Tenascin C associated with malignant neoplastic disease, pancreatic cancer and disease
1) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.28 Pain Relevance 0.45
In contrast serotonergic modulation of S-100beta and tenascin expression was not reversed by any of the 5-HT receptor antagonists tested, although the 5-HT uptake inhibitor, fluoxetine, did reverse the effect of 5-HT on S-100beta expression, as well as tooth-germ development.
Gene_expression (expression) of tenascin in tooth associated with antagonist and fluoxetine
2) Confidence 0.58 Published 1998 Journal Arch. Oral Biol. Section Abstract Doc Link 9796780 Disease Relevance 0 Pain Relevance 0.31
In adult CNS, ECM molecules, such as chondroitin sulfate proteoglycans (CSPG) and tenascin, are expressed at low levels; however, injury can elicit a prominent increase in their expression, which is primarily associated with reactive astrocytes surrounding the injury site.
Gene_expression (expressed) of tenascin in astrocytes associated with injury
3) Confidence 0.58 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.58 Pain Relevance 0
It should be noted, however, that the Nikolsky sign is not specific for SJS/TEN.
Neg (not) Gene_expression (specific) of TEN associated with staphylococcus infection and bullous skin disease
4) Confidence 0.09 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.44 Pain Relevance 0.12
Subsequently, a strong association between SJS/TEN and HLA-B*5801 was found in Japanese patients [34], Thai patients [32], and also, to a lesser extent (55% of cases), in patients of European origin [36].


Gene_expression (/) of TEN associated with staphylococcus infection and bullous skin disease
5) Confidence 0.09 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.00 Pain Relevance 0.40
The chronology of administration of a culprit drug, or time between first administration and development of SJS/TEN, is between 1 and 4 weeks in the majority of cases.
Gene_expression (development) of TEN associated with staphylococcus infection and bullous skin disease
6) Confidence 0.09 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.47 Pain Relevance 0.08
Pathomechanism of SJS/TEN
Gene_expression (Pathomechanism) of TEN associated with staphylococcus infection and bullous skin disease
7) Confidence 0.08 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.28 Pain Relevance 0.36
Mockenhaupt et al. were able to show that almost all cases of SJS/TEN developed within 63 days of starting use of antiepileptic drugs, and that the risk of developing SJS/TEN per 10 000 new users was significantly increased for carbamazepine (1.4 cases per 10 000 users), lamotrigine (2.5), phenobarbital (8.1) and phenytoine (8.3).
Gene_expression (developing) of TEN associated with staphylococcus infection, lamotrigine, bullous skin disease, antiepileptic drug and carbamazepine
8) Confidence 0.08 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.18 Pain Relevance 0.40
Both are rare, with TEN and SJS affecting approximately 1or 2/1,000,000 annually, and are considered medical emergencies as they are potentially fatal.
Gene_expression (affecting) of TEN associated with staphylococcus infection, emergencies and bullous skin disease
9) Confidence 0.08 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC3018455 Disease Relevance 1.38 Pain Relevance 0
It was only as more patients with TEN were reported in the years following Lyell's original publication, that it became clear that TEN was drug induced, and that certain drugs such as sulfonamides, pyrazolones, barbiturates, and antiepileptics were the most frequent triggers of TEN.
Gene_expression (frequent) of TEN associated with staphylococcus infection
10) Confidence 0.08 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.13 Pain Relevance 0
Pathomechanism of SJS/TEN
Gene_expression (/) of TEN associated with staphylococcus infection and bullous skin disease
11) Confidence 0.08 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.27 Pain Relevance 0.36
It was only as more patients with TEN were reported in the years following Lyell's original publication, that it became clear that TEN was drug induced, and that certain drugs such as sulfonamides, pyrazolones, barbiturates, and antiepileptics were the most frequent triggers of TEN.
Gene_expression (frequent) of TEN associated with staphylococcus infection
12) Confidence 0.08 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.16 Pain Relevance 0
Theratope is an investigational therapeutic cancer vaccine consisting of a synthetic form of the tumor associated antigen Sialyl Tn (STn) conjugated to the carrier protein keyhole limpet hemocyanin (KLH).
Gene_expression (synthetic) of Tn associated with cancer
13) Confidence 0.07 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 1.31 Pain Relevance 0
Ten differentially expressed genes mapped to the significant- or suggestive threshold of these two QTLs.
Gene_expression (expressed) of Ten
14) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0.35 Pain Relevance 0
Ten genes (March3, Cep120, Chmp1b, Dcp2, Dtwd2, Isoc1, Lman1, Spire1, Tnfaip8, and Seh1l) mapped to the two significant QTLs and were differentially expressed between A/J and C57BL/6J.
Gene_expression (expressed) of Ten
15) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2932726 Disease Relevance 0.93 Pain Relevance 0.12
All three FCIPs, YC3.60 (Nagai et al., 2004; Kuchibhotla et al., 2008), D3cpv (Palmer et al., 2006; Wallace et al., 2008) and TN-XXL (Mank et al., 2008) have been shown to be functional in vivo.
Gene_expression (functional) of TN-XXL
16) Confidence 0.04 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2866455 Disease Relevance 0 Pain Relevance 0.04
In D3cpv, cpVenus 173 was used with CFP while in TN-XXL a circular permuted Citrine 174 was used with CFP.
Gene_expression (used) of TN-XXL
17) Confidence 0.03 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2866455 Disease Relevance 0 Pain Relevance 0.03
In addition, As1-PRV08 expresses the TN-L15 calcium sensor [29], a FRET-based [Ca2+] indicator.
Gene_expression (expresses) of TN-L15
18) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735035 Disease Relevance 0.48 Pain Relevance 0.26

General Comments

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