INT78194

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.34
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Acan) cell adhesion (Acan) proteinaceous extracellular matrix (Acan)
Anatomy Link Frequency
perineurium 2
cartilage 1
astrocyte 1
Acan (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 45 98.44 Very High Very High Very High
antagonist 6 90.08 High High
Serotonin 2 75.00 Quite High
fluoxetine 1 65.92 Quite High
Peripheral nerve injury 15 55.00 Quite High
Dorsal column 81 35.36 Quite Low
Sciatic nerve 150 23.04 Low Low
dorsal root ganglion 93 16.20 Low Low
withdrawal 15 5.00 Very Low Very Low Very Low
halothane 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 141 97.48 Very High Very High Very High
Cicatrix 12 97.16 Very High Very High Very High
Shock 3 94.56 High High
Targeted Disruption 237 86.48 High High
Nervous System Injury 45 55.00 Quite High
Ganglion Cysts 96 16.20 Low Low
Peripheral Arterial Disease 21 5.00 Very Low Very Low Very Low
Overdose 18 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Frailty 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, NG2, tenascin-C and CSPGs other than NG2 are expressed in similar regions of lesion sites in spinal cord (e.g. the meningeal scar) and peripheral nerves (the perineurium and the surface of bands of Von Büngner) [27,34-37].
Gene_expression (expressed) of CSPG in perineurium associated with cicatrix and spinal cord
1) Confidence 0.75 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.53 Pain Relevance 0.05
For example, NG2, tenascin-C and CSPGs other than NG2 are expressed in similar regions of lesion sites in spinal cord (e.g. the meningeal scar) and peripheral nerves (the perineurium and the surface of bands of Von Büngner) [27,34-37].
Gene_expression (other) of CSPG in perineurium associated with cicatrix and spinal cord
2) Confidence 0.65 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.52 Pain Relevance 0.05
It has also been shown that antibodies against NG2 block its inhibitory effects on neurite growth [8] and that among a variety of CSPGs expressed by a growth-inhibitory astrocyte cell line, NG2 is the one with by far the strongest inhibitory effects on neurite growth [9].
Gene_expression (expressed) of CSPG in astrocyte
3) Confidence 0.58 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.29 Pain Relevance 0.06
Here, it was demonstrated that 5-HT stimulates expression of cartilage proteoglycan core protein, and inhibits expression of S-100beta and tenascin in mandibular explants.
Gene_expression (expression) of proteoglycan core protein in cartilage
4) Confidence 0.51 Published 1998 Journal Arch. Oral Biol. Section Abstract Doc Link 9796780 Disease Relevance 0 Pain Relevance 0.26

General Comments

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