INT78199

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 65
Total Number 67
Disease Relevance 62.88
Pain Relevance 7.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Neu1) plasma membrane (Neu1) lysosome (Neu1)
Anatomy Link Frequency
epithelium 3
pancreas 2
bone marrow 2
mammary gland 1
osteoclast 1
Neu1 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 12 99.32 Very High Very High Very High
rheumatoid arthritis 384 97.04 Very High Very High Very High
spinal inflammation 220 96.48 Very High Very High Very High
cINOD 202 95.04 Very High Very High Very High
methotrexate 142 93.96 High High
Angina 8 93.00 High High
Infliximab 324 91.20 High High
headache 5 87.24 High High
Inflammation 100 85.00 Quite High
Pain 20 72.60 Quite High
Disease Link Frequency Relevance Heat
Cancer 1728 100.00 Very High Very High Very High
Targeted Disruption 210 100.00 Very High Very High Very High
Breast Cancer 845 99.96 Very High Very High Very High
Hyperplasia 62 99.84 Very High Very High Very High
Pancreatic Cancer 38 99.84 Very High Very High Very High
Meningioma 30 99.84 Very High Very High Very High
Carcinoma 258 99.82 Very High Very High Very High
Influenza Virus Infection 583 99.80 Very High Very High Very High
Sprains And Strains 317 99.76 Very High Very High Very High
Small Cell Lung Cancer 5 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Detection of aPL and anti-?
Gene_expression (Detection) of aPL
1) Confidence 0.75 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 0.21 Pain Relevance 0.21
Isotypes of induced anti-dsDNA, aPL/ACL and anti-?
Gene_expression (/) of aPL
2) Confidence 0.65 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 1.69 Pain Relevance 0.97
Occurrence of aPL/ACL and anti-?
Gene_expression (/) of aPL
3) Confidence 0.65 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 1.64 Pain Relevance 1.26
Isotypes of induced anti-dsDNA, aPL/ACL and anti-?
Gene_expression (Isotypes) of aPL
4) Confidence 0.65 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 1.71 Pain Relevance 0.98
In McCulloch study 12.7% 0f 1017 diabetic patients had past history of HZ and 61% of these patients developed HZ before the onset of DM.14 In accordance with our study, Neu and Rodiek detected disorder of glucose utilization in 16 of 28 HZ patients.8
Gene_expression (detected) of Neu associated with diabetes mellitus and herpes zoster
5) Confidence 0.58 Published 2008 Journal Indian Journal of Dermatology Section Body Doc Link PMC2763737 Disease Relevance 2.56 Pain Relevance 0
The chemopreventive effects of tamoxifen have been studied in various mouse models, including transgenic mice with activated neu expression.
Gene_expression (expression) of neu associated with targeted disruption
6) Confidence 0.41 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.25 Pain Relevance 0
Tumor overexpression of HER2/neu is present in about 30% of patients with breast cancer and is associated with a worse histological grade, decreased overall survival and altered sensitivity to chemotherapeutic agents [4,5].
Gene_expression (overexpression) of neu associated with cancer and breast cancer
7) Confidence 0.32 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1579231 Disease Relevance 0.42 Pain Relevance 0
HER2/neu overexpression was assessed on routinely processed, formalin-fixed, paraffin-embedded tissue by immunohistochemical investigations using an automated immunostainer (TechMate 500; Dako, Glostrup, Denmark) and a peroxidase-based detection system in kit form (ChemMate; Dako) according to the manufacturer's instructions.
Gene_expression (overexpression) of neu
8) Confidence 0.32 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1579231 Disease Relevance 0.17 Pain Relevance 0
The signaling pathways activated by PyV-mT include those of Ras, Shc, and phosphotidylinositol 3-kinase, which are frequently activated in human breast cancer (reviewed in [6]) and are also activated by ErbB2 (Her2/neu), a receptor tyrosine kinase that is overexpressed in 30% of breast cancer and is associated with poor outcome [7].
Gene_expression (overexpressed) of neu associated with breast cancer
9) Confidence 0.31 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.89 Pain Relevance 0
Recently, Her2/neu has been implicated in tumor angiogenesis.
Gene_expression (/) of neu associated with cancer
10) Confidence 0.28 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1579231 Disease Relevance 0.50 Pain Relevance 0
HER2/neu overexpression is linked to promotion of angiogenesis in breast cancer.
Gene_expression (overexpression) of neu associated with breast cancer
11) Confidence 0.25 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1579231 Disease Relevance 0.44 Pain Relevance 0.15
Between April 2002 and June 2005, twenty-two patients with metastatic breast cancer with the presence of overexpression or amplification of HER2-/neu, all pre-treated with trastuzumab plus other cytotoxics, were treated with trastuzumab (6 mg/kg every three weeks) in combination with metronomic chemotherapy (MTX 2.5 mg, bid on Day 1 and Day 4 every week) and CTX (50 mg daily) (CM).


Gene_expression (overexpression) of neu associated with advanced or metastatic breast cancer and methotrexate
12) Confidence 0.25 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1579231 Disease Relevance 0.66 Pain Relevance 0.20
HER-2/Neu expression as a progression marker in pancreatic intraepithelial neoplasia.
Gene_expression (expression) of Neu associated with cancer
13) Confidence 0.23 Published 1998 Journal Pol J Pathol Section Title Doc Link 9798411 Disease Relevance 1.29 Pain Relevance 0.08
In conclusion, HER-2/neu expression could be used as an additional marker of hyperplasia, dysplasia and atypia of pancreatic ductal and ductular epithelium in the process of pancreatic epithelial neoplasia.
Gene_expression (expression) of neu in epithelium associated with cancer, cleidocranial dysplasia and hyperplasia
14) Confidence 0.23 Published 1998 Journal Pol J Pathol Section Abstract Doc Link 9798411 Disease Relevance 1.60 Pain Relevance 0.07
The FISH test was performed in the tumor with overexpression of Her2/neu (2+) and resulted positive for amplification of the gene.
Gene_expression (overexpression) of neu associated with cancer
15) Confidence 0.22 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1579231 Disease Relevance 0.50 Pain Relevance 0.03
All patients but one demonstrated overexpression of Her2-/neu (3+) (seven patients determined in the primary (32%) and fifteen patients in the metastatic sites (68%).
Gene_expression (overexpression) of neu
16) Confidence 0.22 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1579231 Disease Relevance 0.45 Pain Relevance 0
HER2/neu transgenic mice offer a compelling test system, because the tumors not only lack ER but also express both HER2/neu and Cox-2, thus recapitulating the relationship between HER2/neu and COX-2 in human breast cancer.
Gene_expression (express) of neu associated with targeted disruption, cancer and breast cancer
17) Confidence 0.20 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.97 Pain Relevance 0.18
Interestingly, both HER2/neu and COX-2 are expressed at higher frequencies in DCIS (50% to 60% and 63% to 85%, respectively), which again is suggestive of a potential interrelationship.
Gene_expression (expressed) of neu associated with noninfiltrating intraductal carcinoma
18) Confidence 0.20 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 1.29 Pain Relevance 0
MMTV/NDL mice express a mutationally activated HER2/neu transgene that drives formation of multiple DCIS-like tumors in each mammary gland.
Spec (like) Gene_expression (express) of neu in mammary gland associated with cancer and noninfiltrating intraductal carcinoma
19) Confidence 0.20 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 1.71 Pain Relevance 0.28
Because HER2/neu can induce COX-2 transcription in vitro, the correlation between HER2/neu and COX-2 expression in breast carcinomas probably reflects a causal relationship [13,24,26,33,34].
Gene_expression (expression) of neu associated with breast cancer
20) Confidence 0.20 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 1.25 Pain Relevance 0

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