INT78202

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Context Info
Confidence 0.31
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 5.44
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peroxisome (GSTK1) intracellular (GSTK1)
Anatomy Link Frequency
cuticles 2
P19 1
sciatic nerve 1
GSTK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Sciatic nerve 6 99.06 Very High Very High Very High
Inflammation 54 98.00 Very High Very High Very High
Action potential 4 94.96 High High
Neuritis 8 94.16 High High
Substantia nigra 2 79.92 Quite High
Bile 2 76.08 Quite High
Demyelination 2 68.64 Quite High
dorsal root ganglion 14 68.52 Quite High
cytokine 25 66.64 Quite High
Paracetamol 4 58.92 Quite High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 63 99.16 Very High Very High Very High
Recurrence 4 99.14 Very High Very High Very High
Breast Cancer 21 98.98 Very High Very High Very High
Cancer 79 98.88 Very High Very High Very High
Nicotine Addiction 110 98.80 Very High Very High Very High
INFLAMMATION 66 98.00 Very High Very High Very High
Disease 83 95.08 Very High Very High Very High
Experimental Autoimmune Neuritis 8 94.16 High High
Dejerine-sottas Disease 2 93.00 High High
Neuropathic Pain 2 87.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mammalian GSTs of the Alpha, Mu, and Pi classes bind with high affinity to matrices such as S-hexylglutathione-sepharose or S-hexylglutathione-agarose [41, 42], but GST enzymes from other classes, such as Theta, bind poorly or not at all [43].
GST Binding (bind) of
1) Confidence 0.31 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0.06 Pain Relevance 0.10
(GST-GSH binding affinity is exploited in commercially available systems for expression of recombinant proteins as GST fusions, such as the pGEX vectors.)
GST Binding (affinity) of
2) Confidence 0.31 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0.05 Pain Relevance 0.09
On the other hand, our finding of an association of the GST Tnull genotype with CAD was in agreement with the report by Tamer et al [6], but not with other previous studies [5,8,10], which did not find an association.
GST Binding (association) of associated with coronary artery disease
3) Confidence 0.26 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1458325 Disease Relevance 1.46 Pain Relevance 0
PMP22 cDNA produced by the reverse transcriptase-polymerase chain reaction from rat sciatic nerve was expressed in Escherichia coli as a fusion protein with glutathione-S-transferase (GST).
GST Binding (protein) of in sciatic nerve associated with sciatic nerve
4) Confidence 0.18 Published 1998 Journal Brain Section Abstract Doc Link 9798745 Disease Relevance 0.68 Pain Relevance 0.46
No changes were observed in controls immunized with GST or in animals immunized with peptide.
GST Binding (immunized) of
5) Confidence 0.18 Published 1998 Journal Brain Section Abstract Doc Link 9798745 Disease Relevance 0.67 Pain Relevance 0.53
There is an absence of data regarding this issue, although earlier work did show that prevention of breast cancer relapse with radiation therapy was greatest among women with elevated levels of GST ?
GST Binding (women) of associated with breast cancer and recurrence
6) Confidence 0.18 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.85 Pain Relevance 0
level would be associated with GST polymorphisms in relation to smoking.
GST Binding (associated) of associated with nicotine addiction
7) Confidence 0.17 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 1.19 Pain Relevance 0.26
kinase activity on itself or on GST-I?
GST Binding (activity) of
8) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
In an in vitro kinase assay, we analyzed the IP-IKK complex and found that GST-I?
GST Binding (found) of
9) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0.06 Pain Relevance 0.03
kinase activity on itself and on GST-I?
GST Binding (activity) of
10) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
EA is known to bind competitively to the hydrophobic cosubstrate (H-site) of GST, while the RAPTA compounds are recognized to react with soft nucleophilic centers such as thiol groups (see above).(134)15 and 16 compounds were therefore thought to be able to bind not only to the enzyme at the H-site but also to interact with the reactive cysteine residues of GST P1-1 (this GST protein possesses two solvent-accessible cysteine residues that affect catalytic activity when modified).
GST Binding (bind) of
11) Confidence 0.03 Published 2010 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC3018145 Disease Relevance 0.08 Pain Relevance 0
To further confirm the interaction between DAT and CPE, we performed GST affinity pull down assay using purified GST fusion peptides containing sequences from DAT-CT (GST-DAT-CT).
GST Binding (affinity) of
12) Confidence 0.02 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0.07 Pain Relevance 0.09
g of protein) were incubated with glutathione-Sepharose beads (Pharmacia, Dorval, Qu├ębec, Canada) bound to the indicated GST-fusion proteins (50 to 100 ?
GST Binding (bound) of
13) Confidence 0.02 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0
Proteins bound to the GST-UBL sample that matched proteins bound by GST-alone were non-specific contaminants that interacted with the matrix and were not analyzed further.
GST Binding (bound) of
14) Confidence 0.01 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0
For GST pull-down, GST-Grb7 proteins were bound to glutathione beads and incubated with total protein extract of P19 for 1 h.
GST Binding (bound) of in P19
15) Confidence 0.01 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.26 Pain Relevance 0.10
Fusion proteins including the R&R consensus from proteins from either hard or soft cuticles fused to glutathione-S-transferase (GST) bind to chitin, although initial analysis indicates that a soft cuticular protein/GST fusion binds more weakly to chitin than a hard cuticular protein/GST fusion.
GST Binding (binds) of in cuticles
16) Confidence 0.01 Published 2002 Journal J Insect Sci Section Body Doc Link PMC405832 Disease Relevance 0 Pain Relevance 0
Fusion proteins including the R&R consensus from proteins from either hard or soft cuticles fused to glutathione-S-transferase (GST) bind to chitin, although initial analysis indicates that a soft cuticular protein/GST fusion binds more weakly to chitin than a hard cuticular protein/GST fusion.
GST Binding (binds) of in cuticles
17) Confidence 0.01 Published 2002 Journal J Insect Sci Section Body Doc Link PMC405832 Disease Relevance 0 Pain Relevance 0

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