INT78210

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Context Info
Confidence 0.65
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.80
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (MCC) plasma membrane (MCC) nucleus (MCC)
cytoplasm (MCC)
Anatomy Link Frequency
reticulum 2
neurons 1
MCC (Homo sapiens)
MCC - C353W (1)
Pain Link Frequency Relevance Heat
interneuron 1 99.98 Very High Very High Very High
Potency 2 98.24 Very High Very High Very High
Serotonin 3 92.04 High High
Migraine 10 85.16 High High
adenocard 1 76.16 Quite High
Pain 2 75.88 Quite High
Neuropathic pain 1 70.84 Quite High
anesthesia 3 70.72 Quite High
cytokine 2 59.96 Quite High
depression 2 40.88 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 56 99.88 Very High Very High Very High
Creutzfeldt Jakob Disease 89 96.96 Very High Very High Very High
Sprains And Strains 55 91.04 High High
Migraine With Aura 6 85.56 High High
Drug Induced Neurotoxicity 4 77.68 Quite High
Pain 2 75.88 Quite High
Neuropathic Pain 1 70.84 Quite High
Aging 78 70.04 Quite High
Disorder Of Lipid Metabolism 4 65.80 Quite High
Apoptosis 9 60.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Out of three cell types tested (R2, LPl1 and serotonergic interneuron MCC) this histone variant is apparently highly expressed only in LPl1 neurons and its level is significantly reduced in neurons from aged animals (Figure 8B).
Gene_expression (expressed) of MCC in neurons associated with interneuron
1) Confidence 0.65 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2910937 Disease Relevance 0.07 Pain Relevance 0.05
Coexpression of a dominant-negative P2X4 mutant (C353W) with P2X7, inhibited P2X7 receptor mediated currents by greater than 2-fold, whereas a nonfunctional but non-dominant-negative mutant (S341W) did not.
Gene_expression (Coexpression) of mutant (C353W)
2) Confidence 0.02 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17785580 Disease Relevance 0.21 Pain Relevance 0.21
While some inherited prion diseases may indeed not be transmissible, and may represent prion proteinopathies [193–195], many pathogenic mutations have yet to be tested in transgenic mice expressing the homotypic human mutant protein.
Gene_expression (expressing) of mutant protein associated with targeted disruption and creutzfeldt jakob disease
3) Confidence 0.01 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.92 Pain Relevance 0.07
Western analysis of extracts from these cells demonstrated that much less Y355X mutant protein was produced from the same amount of transfected DNA suggesting that the mutant receptor was significantly less stable than the wild-type receptor (Figure 4A).
Gene_expression (produced) of Y355X mutant protein
4) Confidence 0.01 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1368963 Disease Relevance 0.13 Pain Relevance 0
Metabolic labeling studies showed that the mutants were synthesized and associated with the beta-subunit, except for the alpha2HW887R mutant, which was poorly synthesized, and the alpha1BW890R, which was partially retained in the endoplasmic reticulum. [3H]ouabain binding showed the presence of the alpha2HR689Q and alpha2HM731T at the membrane, whereas the alpha2HL764P and alpha2HW887R could not be detected.
Gene_expression (synthesized) of mutant in reticulum
5) Confidence 0.01 Published 2004 Journal Neuromolecular Med. Section Abstract Doc Link 15970628 Disease Relevance 0.24 Pain Relevance 0.24
Metabolic labeling studies showed that the mutants were synthesized and associated with the beta-subunit, except for the alpha2HW887R mutant, which was poorly synthesized, and the alpha1BW890R, which was partially retained in the endoplasmic reticulum. [3H]ouabain binding showed the presence of the alpha2HR689Q and alpha2HM731T at the membrane, whereas the alpha2HL764P and alpha2HW887R could not be detected.
Neg (except) Gene_expression (synthesized) of mutant in reticulum
6) Confidence 0.01 Published 2004 Journal Neuromolecular Med. Section Abstract Doc Link 15970628 Disease Relevance 0.24 Pain Relevance 0.24
Replacing the highly conserved Asp106 in transmembrane region III by asparagine eliminated D-[3H]-lysergic acid diethylamide ([3H]LSD) binding to the mutant receptor transiently expressed in HEK293 cells.
Gene_expression (expressed) of mutant receptor
7) Confidence 0.00 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9798944 Disease Relevance 0 Pain Relevance 0.16

General Comments

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