INT7822

Context Info Confidence 0.47 First Reported 1992 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.11 Pain Relevance 0.89

nucleus (Tbpl1) DNA binding (Tbpl1) cytoplasm (Tbpl1)

Tbpl1 (Mus musculus)

Pain Link Frequency Relevance Heat TRP channel 8 100.00 Mechanosensation 2 99.60 Cholecystokinin 8 97.28 agonist 3 97.04 Intracerebroventricular 1 92.88 Enkephalin 5 83.76 Delta opioid receptors 2 75.00 MU agonist 1 64.48 qutenza 1 43.40 Opioid 1 41.20

Disease Link Frequency Relevance Heat Stress 3 56.32 Helminth Infection 1 54.92 Polycystic Kidney Disease 7 11.12 Pressure And Volume Under Development 7 8.80 Targeted Disruption 4 5.00 Cyst 3 5.00 Congenital Anomalies 2 5.00 Hyperalgesia 1 5.00 Renal Failure 1 5.00 Cystic Kidney Diseases 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This was quantified by measuring the effects of both inhibitors on the in vivo binding of [3H]propionyl-Tyr(SO3H)-gNle-mGly-Trp-(N-Me)Nle-Asp-Phe-NH2 ([3H]pBC 264), a selective and highly potent CCK-B agonist.

Trp Binding (binding) of associated with agonist and cholecystokinin

1) Confidence 0.47 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1357099 Disease Relevance 0 Pain Relevance 0.79

Because TRP channels are known to engage in heteromeric interactions that generate channels with novel functional properties (Schaefer, 2005), we tested whether TRPP2 physically interacts with TRPV4.

TRP Binding (engage) of associated with trp channel

2) Confidence 0.04 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.11 Pain Relevance 0.10

General Comments

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