INT78226

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 43
Total Number 46
Disease Relevance 22.14
Pain Relevance 7.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp) nucleus (Mbp) cytoplasm (Mbp)
Anatomy Link Frequency
oligodendrocytes 3
brains 2
nucleus 2
eosinophils 2
T cells 2
Mbp (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 251 99.64 Very High Very High Very High
Demyelination 306 99.42 Very High Very High Very High
Inflammation 209 99.12 Very High Very High Very High
Spinal cord 258 98.68 Very High Very High Very High
Multiple sclerosis 249 97.96 Very High Very High Very High
Neuropathic pain 131 97.32 Very High Very High Very High
Neuritis 138 96.68 Very High Very High Very High
unmyelinated 25 96.00 Very High Very High Very High
Sciatic nerve 95 94.00 High High
midbrain 3 90.76 High High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 1110 99.76 Very High Very High Very High
Demyelinating Disease 416 99.42 Very High Very High Very High
INFLAMMATION 226 99.12 Very High Very High Very High
Autoimmune Disease 43 98.60 Very High Very High Very High
Injury 101 98.32 Very High Very High Very High
Neuropathic Pain 199 97.32 Very High Very High Very High
Optic Neuritis 132 96.92 Very High Very High Very High
Paralysis 48 96.80 Very High Very High Very High
Disease 275 96.08 Very High Very High Very High
Neuritis 6 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PACAP (5 x 10(-8) mol/kg) injections produced a long-lasting potent decline of MBP, rCBF and cerebral pO2.
Gene_expression (produced) of MBP
1) Confidence 0.75 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 15518894 Disease Relevance 0.33 Pain Relevance 0.15
After 48 h, the cultures were fixed and stained for MBP (myelin basic protein).
Gene_expression (fixed) of myelin basic protein
2) Confidence 0.65 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 0 Pain Relevance 0.05
However, Western blotting showed that the levels of the myelin proteins myelin-associated glycoprotein (MAG) and myelin basic protein (MBP) in the CNS of the mutant at P6 were reduced compared with wild-type tissue and that they were similar to those observed at P4 in the wild-type (Fig. 2 B).
Gene_expression (levels) of myelin basic protein associated with central nervous system
3) Confidence 0.59 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0.09 Pain Relevance 0.28
However, Western blotting showed that the levels of the myelin proteins myelin-associated glycoprotein (MAG) and myelin basic protein (MBP) in the CNS of the mutant at P6 were reduced compared with wild-type tissue and that they were similar to those observed at P4 in the wild-type (Fig. 2 B).
Gene_expression (levels) of MBP associated with central nervous system
4) Confidence 0.59 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0.09 Pain Relevance 0.28
(25–35)-injected mice receiving vehicle, and administration of Kihi-to resulted in an increase in MBP expression levels in the perirhinal cortex (Figures 6 and 7).


Gene_expression (expression) of MBP in perirhinal cortex
5) Confidence 0.59 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.07 Pain Relevance 0
Following the memory retention test, the levels of P-NF-H, MAP2, synaptophysin and myelin basic protein (MBP, a myelin marker) were measured in the brains of the mice by immunohistochemistry.
Gene_expression (levels) of MBP in brains
6) Confidence 0.59 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.26 Pain Relevance 0.14
Expression levels of MBP were decreased in the cortex, striatum axonal bundles and corpus callosum of A?
Gene_expression (Expression) of MBP in striatum
7) Confidence 0.59 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.11 Pain Relevance 0
Two transcription factors (Scip and Krox20) regulating progression of myelination and myelin protein expression respectively, together with the expression of four myelin proteins (Pmp22, Mbp, Mag and Plp) were evaluated.
Gene_expression (expression) of Mbp
8) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877074 Disease Relevance 0.15 Pain Relevance 0.08
For each lane, there is a ratio of MBP product/?
Gene_expression (product) of MBP
9) Confidence 0.57 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0 Pain Relevance 0.18
Seven days after the passive transfer of myelin basic protein (MBP)-reactive T cell blasts, we observed a significant infiltration of eosinophils into the optic nerves of the mice.
Gene_expression (transfer) of MBP in T cell
10) Confidence 0.55 Published 1998 Journal Lab. Invest. Section Abstract Doc Link 9800949 Disease Relevance 1.12 Pain Relevance 0.25
Using an in situ hybridization technique that gives high resolution and is very sensitive, we examined myelin basic protein and proteolipid protein gene expression three and twenty-four hours after a H-I insult.
Gene_expression (expression) of myelin basic protein
11) Confidence 0.52 Published 2001 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 11255033 Disease Relevance 0.89 Pain Relevance 0.08
Among the myelin proteins investigated, expression levels of MOG, MBP and MAG, except that of CNPase, were significantly attenuated in 6 week-old Olig1?
Gene_expression (levels) of MBP
12) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.42 Pain Relevance 0.11
In the present study, we demonstrate that Olig1 deficiency, or reduced expression of MOG, MBP and MAG caused by Olig1 deficiency, delayed the onset of EAE.
Gene_expression (expression) of MBP associated with multiple sclerosis
13) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.87 Pain Relevance 0.29
Olig1 is localized in the nucleus during the development phase and may function as a transcriptional regulator for myelin-specific gene expression such as myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP) and myelin-associated glycoprotein (MAG) [12], [14].
Gene_expression (expression) of MBP in nucleus
14) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 1.25 Pain Relevance 0.56
Among the myelin proteins investigated, expression levels of MOG, MBP and MAG, except that of CNPase, were significantly attenuated in 6 week-old Olig1?
Gene_expression (expression) of MBP
15) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.42 Pain Relevance 0.11
Olig1 is localized in the nucleus during the development phase and may function as a transcriptional regulator for myelin-specific gene expression such as myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP) and myelin-associated glycoprotein (MAG) [12], [14].
Gene_expression (expression) of myelin basic protein in nucleus
16) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 1.20 Pain Relevance 0.56
Therefore, the reduced expressions of MBP and MAG in Olig1?
Gene_expression (expressions) of MBP
17) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.84 Pain Relevance 0.13
Following the memory retention test, the levels of P-NF-H, MAP2, synaptophysin and myelin basic protein (MBP, a myelin marker) were measured in the brains of the mice by immunohistochemistry.
Gene_expression (levels) of myelin basic protein in brains
18) Confidence 0.51 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.26 Pain Relevance 0.14
GA was synthesized to resemble the structure of myelin basic protein (MBP), one of the major components involved in EAE and multiple sclerosis but instead of inducing the disease, it was found to be protective [22].
Gene_expression (synthesized) of myelin basic protein associated with multiple sclerosis and disease
19) Confidence 0.50 Published 2009 Journal Malar J Section Body Doc Link PMC2651188 Disease Relevance 1.56 Pain Relevance 0.24
GA was synthesized to resemble the structure of myelin basic protein (MBP), one of the major components involved in EAE and multiple sclerosis but instead of inducing the disease, it was found to be protective [22].
Gene_expression (synthesized) of MBP associated with multiple sclerosis and disease
20) Confidence 0.50 Published 2009 Journal Malar J Section Body Doc Link PMC2651188 Disease Relevance 1.57 Pain Relevance 0.24

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