INT78232

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 6.26
Pain Relevance 6.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (P2rx3)
Anatomy Link Frequency
neurons 2
neuronal 1
nerve 1
skin 1
dorsal root ganglion 1
P2rx3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 37 100.00 Very High Very High Very High
Sciatic nerve 2 100.00 Very High Very High Very High
Inflammation 28 99.92 Very High Very High Very High
nMDA receptor 12 99.80 Very High Very High Very High
qutenza 37 99.16 Very High Very High Very High
Pain 68 98.50 Very High Very High Very High
agonist 94 98.48 Very High Very High Very High
Neuropathic pain 19 98.40 Very High Very High Very High
nociceptor 89 98.38 Very High Very High Very High
IPN 15 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 28 99.92 Very High Very High Very High
Nociception 122 99.44 Very High Very High Very High
Pain 71 98.50 Very High Very High Very High
Neuropathic Pain 55 98.40 Very High Very High Very High
Inflammatory Pain 15 98.32 Very High Very High Very High
Ganglion Cysts 532 97.52 Very High Very High Very High
Nervous System Injury 24 96.00 Very High Very High Very High
Hyperalgesia 31 94.68 High High
Pathologic Processes 1 77.52 Quite High
Injury 14 67.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Understanding how antagonists interact with the P2X3 receptor can aid in the discovery and development of P2X3-specific antagonists.
P2X3 Binding (interact) of associated with antagonist
1) Confidence 0.41 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16014755 Disease Relevance 0.53 Pain Relevance 0.63
The P2X3 antagonist P1, P5-di[inosine-5'] pentaphosphate binds to the desensitized state of the receptor in rat dorsal root ganglion neurons.
P2X3 Binding (binds) of in dorsal root ganglion associated with ganglion cysts, antagonist and root ganglion neuron
2) Confidence 0.36 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16014755 Disease Relevance 0.54 Pain Relevance 0.64
We further demonstrated that sensitization of P2X3 receptors arises from an increase in receptor function.
P2X3 Binding (sensitization) of
3) Confidence 0.35 Published 2005 Journal Pain Section Abstract Doc Link 16298067 Disease Relevance 1.02 Pain Relevance 0.42
Thus, the enhancement of trafficking of P2X3 receptors is likely an important mechanism contributing to the increase in receptor function after nerve injury.
P2X3 Binding (trafficking) of in nerve associated with nervous system injury
4) Confidence 0.35 Published 2005 Journal Pain Section Abstract Doc Link 16298067 Disease Relevance 0.68 Pain Relevance 0.36
Finally, P2X3-ir accumulated proximal to the site of sciatic nerve ligation, and was seen in nerve fibres in skin and corneal epithelium.
P2X3 Binding (ligation) of in corneal epithelium associated with sciatic nerve
5) Confidence 0.34 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9824460 Disease Relevance 0 Pain Relevance 0.46
These findings indicate that PAR2 agonists may potentiate the sensitivity of P2X3 ion channel to noxious stimuli, and the interaction between PAR2 and P2X3 may be an important mechanism underlying inflammatory pain.
P2X3 Binding (interaction) of associated with ipn and agonist
6) Confidence 0.33 Published 2006 Journal Neuroreport Section Abstract Doc Link 16951565 Disease Relevance 0.25 Pain Relevance 0.59
This supports the action of IP5I as a noncompetitive antagonist that interacts with the desensitized state of the P2X3 receptor.
P2X3 Binding (interacts) of associated with antagonist
7) Confidence 0.32 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16014755 Disease Relevance 0.40 Pain Relevance 0.63
Nerve endings of nociceptors (pain-sensing neurons) express an unusual subtype of ATP-gated ion channel, the P2X3 receptor, that rapidly desensitizes (<100 msec) and slowly recovers (>20 min).
P2X3 Binding (recovers) of in neurons associated with pain and nociceptor
8) Confidence 0.31 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9801363 Disease Relevance 0.10 Pain Relevance 0.20
P2X3 is a ligand-gated ion channel for ATP, and belongs to P2X family.
P2X3 Binding (ligand) of
9) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 0.56 Pain Relevance 0.68
The interaction between PGE2 and P2X3 receptors has not been well delineated.
P2X3 Binding (interaction) of in PGE2
10) Confidence 0.25 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2063498 Disease Relevance 0.27 Pain Relevance 0.09
This led us to test the possibility that interaction between the P2X3 receptor and PIP2 involved its N-terminal domain.
P2X3 Binding (interaction) of
11) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0 Pain Relevance 0.03
On the other hand, the F346-T364 P2X3 peptide did not bind to any of the lipids spotted on the membrane.
P2X3 Neg (not) Binding (bind) of
12) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0 Pain Relevance 0
Again, no such interaction was observed as the binding of N-terminal P2X3 constructs to phospholipid membranes was not detected.
P2X3 Binding (binding) of
13) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0 Pain Relevance 0.03
Specific TaqMan assays for mouse and rat target mRNA encoding P2X3, P2X2 and TRPV1, neuronal specific ?
P2X3 Binding (specific) of in neuronal
14) Confidence 0.22 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.18 Pain Relevance 0.09
Surprisingly, no binding of the recombinant P2X3 constructs to any phospholipids could be detected above background.
recombinant P2X3 Neg (no) Binding (binding) of
15) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0 Pain Relevance 0
In addition, roles for the ligand-gated P2X3 and NMDA receptors, as well as pacemaker HCN channels have also been invoked in the pathogenesis of neuropathic pain.
P2X3 Binding (ligand-gated) of associated with nmda receptor and neuropathic pain
16) Confidence 0.20 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469043 Disease Relevance 0.58 Pain Relevance 0.76
Therefore P2X3 is the only member of the P2X family, so far, that does not display direct binding to phosphoinositides using the lipid strip assay.
P2X3 Binding (binding) of
17) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0.11 Pain Relevance 0.06
Phospholipid modulation of P2X3 receptors does not involve direct binding
P2X3 Binding (binding) of
18) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0 Pain Relevance 0
Phosphoinositides are negatively charged lipids, therefore we investigated potential interactions with basic residues on the intracellular domain of the P2X3 channel subunit and confirmed P2X2 subunit binding using a lipid strip assay.
P2X3 Binding (interactions) of
19) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0 Pain Relevance 0
We cannot rule out, however, the possibility that phosphoinositide binding requires the intact P2X3 receptor subunit.
P2X3 Binding (binding) of
20) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0.13 Pain Relevance 0.08

General Comments

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