INT78233

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Context Info
Confidence 0.56
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 36
Total Number 37
Disease Relevance 21.49
Pain Relevance 17.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (P2rx3)
Anatomy Link Frequency
neurons 9
sensory neurons 2
masseter 2
visceral 1
midbrain 1
P2rx3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Brush evoked pain 153 99.90 Very High Very High Very High
c fibre 3 99.84 Very High Very High Very High
Visceral pain 2 99.66 Very High Very High Very High
GABAergic 1 99.64 Very High Very High Very High
Pain 233 99.54 Very High Very High Very High
dorsal root ganglion 818 99.52 Very High Very High Very High
ASIC 38 99.52 Very High Very High Very High
Lasting pain 43 99.44 Very High Very High Very High
midbrain 2 99.44 Very High Very High Very High
Inflammation 63 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 370 99.90 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 99.66 Very High Very High Very High
Pain 268 99.54 Very High Very High Very High
Ganglion Cysts 1382 99.52 Very High Very High Very High
Nervous System Injury 373 99.48 Very High Very High Very High
INFLAMMATION 65 99.42 Very High Very High Very High
Nociception 177 99.30 Very High Very High Very High
Post Operative Pain 1 99.30 Very High Very High Very High
Injury 56 98.90 Very High Very High Very High
Hyperalgesia 54 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blots showed a trend toward increases of P2X3-receptor protein between pregnancy (day 10) and parturition (day 22-23) in the cervix, but no significant changes in the DRG or spinal cord.
Positive_regulation (increases) of P2X3 in cervix associated with dorsal root ganglion and spinal cord
1) Confidence 0.56 Published 2005 Journal Cell Tissue Res. Section Abstract Doc Link 15902498 Disease Relevance 0.80 Pain Relevance 0.65
Several lines of evidence suggest that extracellular ATP plays a role in pain signaling through the activation of ionotropic P2X-receptors, especially homomeric P2X3- and heteromeric P2X2/3-receptors on capsaicin-sensitive and -insensitive primary afferent neurons, respectively, at peripheral and spinal sites.
Positive_regulation (activation) of P2X3 in spinal associated with pain and qutenza
2) Confidence 0.47 Published 2007 Journal Neuroscience Section Abstract Doc Link 17543465 Disease Relevance 0.38 Pain Relevance 0.65
Finally, P2X3-ir accumulated proximal to the site of sciatic nerve ligation, and was seen in nerve fibres in skin and corneal epithelium.
Positive_regulation (accumulated) of P2X3 in corneal epithelium associated with sciatic nerve
3) Confidence 0.47 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9824460 Disease Relevance 0 Pain Relevance 0.46
Overall, data from real time RT-PCR, Western blotting and immunocytochemistry suggest upregulation of P2X3 and TRPV1 receptors in culture with respect to the ganglion.


Positive_regulation (upregulation) of P2X3 in ganglion associated with ganglion cysts
4) Confidence 0.42 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.42 Pain Relevance 0.38
We reported that activation of P2X2/3 heteromeric channels in A delta-DRG neurons causes tactile allodynia and activation of P2X3 in C-fiber causes nocifensive behavior.
Positive_regulation (activation) of P2X3 in neurons associated with c fibre and brush evoked pain
5) Confidence 0.40 Published 2004 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 15467256 Disease Relevance 0.36 Pain Relevance 0.46
These results suggest that the enhanced pain response caused by PAR2 activation is not through direct increase of the P2X3 current amplitude, and the acceleration of P2X3 opening may participate in the enhanced pain response in a long-time view.
Positive_regulation (increase) of P2X3 associated with pain
6) Confidence 0.39 Published 2010 Journal Neuroreport Section Abstract Doc Link 20118742 Disease Relevance 0.50 Pain Relevance 0.43
In this study, we performed the patch-clamp experiments in cultured dorsal root ganglion neurons and found that when incubated with trypsin or the PAR2 agonist SL-NH2 for a short time (3 min), instead of increasing, P2X3 currents amplitude decreased significantly.
Positive_regulation (increasing) of P2X3 in neurons associated with ganglion cysts, agonist and root ganglion neuron
7) Confidence 0.39 Published 2010 Journal Neuroreport Section Abstract Doc Link 20118742 Disease Relevance 0.49 Pain Relevance 0.41
When PIP2 was then applied to the membrane patch facing the intracellular side of the membrane, it activated both P2X2 and P2X3 receptors (Fig. 4).
Positive_regulation (activated) of P2X3
8) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0 Pain Relevance 0
Importantly, Ca2+ facilitates P2X3 current to precisely the same level whether a transient Ca2+ change occurred just before or several minutes before activating the channels with ATP.
Spec (whether) Positive_regulation (facilitates) of P2X3
9) Confidence 0.36 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9801363 Disease Relevance 0.09 Pain Relevance 0.17
Here we show that Ca2+, or certain other polyvalent cations, binds to an extracellular site on rat sensory neurons and can increase current through P2X3 channels more than 10-fold.
Positive_regulation (increase) of P2X3 in sensory neurons
10) Confidence 0.36 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9801363 Disease Relevance 0.09 Pain Relevance 0.18
Electrophysiological studies indicate that ATP produces large inward currents by activating P2X3 homomeric and P2X2/3 heteromeric receptors, thus evoking depolarization in small and medium DRG neurons [11,13,14,24,25].
Positive_regulation (activating) of P2X3 in neurons associated with dorsal root ganglion
11) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 1.28 Pain Relevance 0.47
An increase in P2X3 receptor-mediated responses is one of the major reasons for the enhancement [11,31].
Positive_regulation (increase) of P2X3
12) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 1.28 Pain Relevance 0.44
Based on the finding described in the present study, we concluded that CysLT2, the receptor of LTC4, located in the primary afferent, might modulate the activation of P2X3 by the injection of ??
Positive_regulation (activation) of P2X3
13) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 0.59 Pain Relevance 0.56
This view is supported by evidence that persistent inflammation by CFA is accompanied by an upregulation of both P2X2 and P2X3 receptors in sensory neurons [113].
Positive_regulation (upregulation) of P2X3 in sensory neurons associated with inflammation
14) Confidence 0.34 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 1.00 Pain Relevance 0.80
The mechanisms responsible for the increase include upregulation of P2X3 receptors [11], enhancement of trafficking of P2X3 receptors toward the membrane [31] and activation of calmodulin protein kinase II [34].
Positive_regulation (upregulation) of P2X3
15) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 1.24 Pain Relevance 0.54
Activation of P2X3 and P2X2+3 receptors (P2X3R/P2X2+3R), ionotropic ATP receptor subtypes, is involved in nerve injury-induced cPLA2 activation in DRG neurons [2]; however, the mechanism underlying cPLA2 activation via P2X3R/P2X2+3R remains to be elucidated.
Positive_regulation (Activation) of P2X3 in neurons associated with dorsal root ganglion and nervous system injury
16) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.98 Pain Relevance 0.58
Activation of P2X3 and P2X2+3 receptors (P2X3R/P2X2+3R), ionotropic ATP receptor subtypes, is involved in nerve injury-induced cPLA2 activation in DRG neurons [2]; however, the mechanism underlying cPLA2 activation via P2X3R/P2X2+3R remains to be elucidated.
Positive_regulation (Activation) of P2X3R in neurons associated with dorsal root ganglion and nervous system injury
17) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.98 Pain Relevance 0.58
Activation of P2X3 and P2X2+3 receptors (P2X3R/P2X2+3R), ionotropic ATP receptor subtypes, is involved in nerve injury-induced cPLA2 activation in DRG neurons [2]; however, the mechanism underlying cPLA2 activation via P2X3R/P2X2+3R remains to be elucidated.
Positive_regulation (Activation) of ATP receptor in neurons associated with dorsal root ganglion and nervous system injury
18) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.98 Pain Relevance 0.58
ATP receptor-dependent activation of CaMKII in cultured primary sensory neurons
Positive_regulation (activation) of ATP receptor in primary sensory neurons
19) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.34 Pain Relevance 0.57
Because the ATP-evoked current is not blocked by cadmium [38,39], our results suggest that Ca2+ influx via the activation of P2X3R/P2X2+3R may not be enough to activate CaMKII and that VDCC activation (presumably resulting from a depolarization of DRG neurons by stimulating P2X3R/P2X2+3R) may contribute to CaMKII activation in DRG neurons.
Positive_regulation (activation) of P2X3R in neurons associated with dorsal root ganglion
20) Confidence 0.31 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.95 Pain Relevance 0.80

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