INT78234
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
On the other hand, inflammation caused a twofold to threefold increase in both ATP-activated currents, altered the voltage dependence of P2X receptors, and enhanced the expression of P2X2 and P2X3 receptors. | |||||||||||||||
| |||||||||||||||
|
A sample of mock-transfected cells was simultaneously probed with the P2X2 and P2X3 subunit-specific polyclonal antibodies | |||||||||||||||
| |||||||||||||||
|
P2X(3) receptor antagonist A-317491 reduced P2X agonist activated currents and P2X(3) mRNA expression. | |||||||||||||||
| |||||||||||||||
|
GABAA receptors mediated modulation of expression of both P2X2 and P2X4 receptors, which may play an important role in the regulation of seizure activity in the gerbil hippocampus [139]. | |||||||||||||||
| |||||||||||||||
|
Overall, the present data demonstrate that activation of P2X(3) receptors contribute to the expression of chronic inflammatory and neuropathic pain states and that relief form these forms of chronic pain might be achieved by selective blockade of P2X(3 )receptor expression or activation. | |||||||||||||||
| |||||||||||||||
|
Formalin-induced increase in P2X(3) receptor expression in dorsal root ganglia: implications for nociception. | |||||||||||||||
| |||||||||||||||
|
These data suggest that formalin injection leads to early upregulation of P2X(3) expression in the spinal cord and DRG and that this may be one of the mechanisms giving rise to nociception. | |||||||||||||||
| |||||||||||||||
|
Our data demonstrate that EAN induces mechanical allodynia and P2X(4)R expression in spinal microglia, suggesting that EAN is a good animal model for neuropathic pain in polyneuropathy and spinal microglia activation might participate in EAN-induced neuropathic pain. | |||||||||||||||
| |||||||||||||||
|
Expression of the P2X(3) transcript in the DRG was unchanged 30 min and 1 h after formalin injection, but increased after 12 h. | |||||||||||||||
| |||||||||||||||
|
Expression of the P2X(3) transcript in the DRG was unchanged 30 min and 1 h after formalin injection, but increased after 12 h. | |||||||||||||||
| |||||||||||||||
|
Taken together with the previous reports that P2X(3) expression increases in the spared DRG neurons in other neuropathic pain models, there appears to be differences in the phenotypic changes and pathomechanisms of the various neuropathic pain models. | |||||||||||||||
| |||||||||||||||
|
Expressions of TRPV2, P2X(3), and ASIC3 increased in all DRG neurons. | |||||||||||||||
| |||||||||||||||
|
The expression of P2X(3) receptor in DRG neurons was increased after CCI. | |||||||||||||||
| |||||||||||||||
|
We also found that the expression level of P2X(4) was increased strikingly in spinal cord microgila after nerve injury and that pharmacological blockade or inhibition of the expression of P2X(4) reversed the allodynia. | |||||||||||||||
| |||||||||||||||
|
These data suggest that formalin injection leads to early upregulation of P2X(3) expression in the spinal cord and DRG and that this may be one of the mechanisms giving rise to nociception. | |||||||||||||||
| |||||||||||||||
|
In addition, expressions of P2X(3) and ASIC3 also increased in muscle afferent neurons in DRGs. | |||||||||||||||
| |||||||||||||||
|
A memory for extracellular Ca2+ by speeding recovery of P2X receptors from desensitization. | |||||||||||||||
| |||||||||||||||
|
Increased expression of CGRP, SP, P2X(3), and TRPV1 in the TG may be involved in the behavioral changes in this model. | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.