INT78234

Context Info Confidence 0.69 First Reported 1998 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 18 Total Number 18 Disease Relevance 12.86 Pain Relevance 12.75

plasma membrane (P2rx2)

Anatomy Link Frequency DRG 7 neurons 6 spinal cord 5 hippocampus 2 afferent neurons 2 P2rx2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat allodynia 17 100.00 dorsal root ganglion 13 100.00 substance P 7 100.00 Calcitonin gene-related peptide 6 100.00 agonist 11 99.98 Neuritis 10 99.98 Cancer pain 4 99.92 Eae 11 99.72 Spinal cord 28 99.68 Pain 38 99.66

Disease Link Frequency Relevance Heat Neuropathic Pain 38 100.00 Ganglion Cysts 20 100.00 Experimental Autoimmune Neuritis 10 99.98 Cancer Pain 4 99.92 Injury 15 99.72 Mouth Cancer 4 99.72 Pain 26 99.12 Nociception 31 98.32 Nervous System Injury 8 98.28 INFLAMMATION 12 97.58

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

On the other hand, inflammation caused a twofold to threefold increase in both ATP-activated currents, altered the voltage dependence of P2X receptors, and enhanced the expression of P2X2 and P2X3 receptors.

Positive_regulation (enhanced) of Gene_expression (expression) of P2X2 associated with addiction and inflammation

1) Confidence 0.69 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11756492 Disease Relevance 0.89 Pain Relevance 0.68

A sample of mock-transfected cells was simultaneously probed with the P2X2 and P2X3 subunit-specific polyclonal antibodies

Positive_regulation (simultaneously) of Gene_expression (probed) of P2X2

2) Confidence 0.37 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.31

P2X(3) receptor antagonist A-317491 reduced P2X agonist activated currents and P2X(3) mRNA expression.

Positive_regulation (activated) of Gene_expression (expression) of P2X associated with antagonist and agonist

3) Confidence 0.26 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18158099 Disease Relevance 1.09 Pain Relevance 0.74

GABAA receptors mediated modulation of expression of both P2X2 and P2X4 receptors, which may play an important role in the regulation of seizure activity in the gerbil hippocampus [139].

Positive_regulation (mediated) of Gene_expression (expression) of P2X2 in hippocampus associated with convulsion and hippocampus

4) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.79 Pain Relevance 0.46

Overall, the present data demonstrate that activation of P2X(3) receptors contribute to the expression of chronic inflammatory and neuropathic pain states and that relief form these forms of chronic pain might be achieved by selective blockade of P2X(3 )receptor expression or activation.

Positive_regulation (activation) of Gene_expression (expression) of P2X associated with inflammation, lasting pain and neuropathic pain

5) Confidence 0.19 Published 2002 Journal Pain Section Abstract Doc Link 12237180 Disease Relevance 0.94 Pain Relevance 0.83

Formalin-induced increase in P2X(3) receptor expression in dorsal root ganglia: implications for nociception.

Positive_regulation (increase) of Gene_expression (expression) of P2X in dorsal root ganglia associated with nociception and nociceptor

6) Confidence 0.16 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 19473342 Disease Relevance 0.29 Pain Relevance 0.58

These data suggest that formalin injection leads to early upregulation of P2X(3) expression in the spinal cord and DRG and that this may be one of the mechanisms giving rise to nociception.

Positive_regulation (upregulation) of Gene_expression (expression) of P2X in spinal cord associated with nociception and spinal cord

7) Confidence 0.16 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19473342 Disease Relevance 0.17 Pain Relevance 0.17

Our data demonstrate that EAN induces mechanical allodynia and P2X(4)R expression in spinal microglia, suggesting that EAN is a good animal model for neuropathic pain in polyneuropathy and spinal microglia activation might participate in EAN-induced neuropathic pain.

Positive_regulation (induces) of Gene_expression (expression) of P2X in microglia associated with neuropathy, allodynia, neuropathic pain and neuritis

8) Confidence 0.15 Published 2008 Journal Neuroscience Section Abstract Doc Link 18276080 Disease Relevance 1.54 Pain Relevance 1.50

Expression of the P2X(3) transcript in the DRG was unchanged 30 min and 1 h after formalin injection, but increased after 12 h.

Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (Expression) of P2X in DRG

9) Confidence 0.13 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19473342 Disease Relevance 0.20 Pain Relevance 0.24

Expression of the P2X(3) transcript in the DRG was unchanged 30 min and 1 h after formalin injection, but increased after 12 h.

Positive_regulation (increased) of Gene_expression (Expression) of P2X in DRG

10) Confidence 0.13 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19473342 Disease Relevance 0.20 Pain Relevance 0.25

Taken together with the previous reports that P2X(3) expression increases in the spared DRG neurons in other neuropathic pain models, there appears to be differences in the phenotypic changes and pathomechanisms of the various neuropathic pain models.

Positive_regulation (increases) of Gene_expression (expression) of P2X in neurons associated with eae

11) Confidence 0.07 Published 2002 Journal Pain Section Abstract Doc Link 12237189 Disease Relevance 0.52 Pain Relevance 0.80

Expressions of TRPV2, P2X(3), and ASIC3 increased in all DRG neurons.

Positive_regulation (increased) of Gene_expression (Expressions) of P2X in neurons associated with dorsal root ganglion

12) Confidence 0.06 Published 2010 Journal Pain Section Abstract Doc Link 20378247 Disease Relevance 0.92 Pain Relevance 1.00

The expression of P2X(3) receptor in DRG neurons was increased after CCI.

Positive_regulation (increased) of Gene_expression (expression) of P2X in neurons associated with dorsal root ganglion and eae

13) Confidence 0.06 Published 2010 Journal Brain Res. Section Abstract Doc Link 19968976 Disease Relevance 1.65 Pain Relevance 1.26

We also found that the expression level of P2X(4) was increased strikingly in spinal cord microgila after nerve injury and that pharmacological blockade or inhibition of the expression of P2X(4) reversed the allodynia.

Positive_regulation (increased) of Gene_expression (expression) of P2X in spinal cord associated with nervous system injury, allodynia and spinal cord

14) Confidence 0.06 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14978347 Disease Relevance 0.91 Pain Relevance 1.06

These data suggest that formalin injection leads to early upregulation of P2X(3) expression in the spinal cord and DRG and that this may be one of the mechanisms giving rise to nociception.

Positive_regulation (upregulation) of in DRG Gene_expression (expression) of P2X in spinal cord associated with nociception and spinal cord

15) Confidence 0.06 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19473342 Disease Relevance 0.17 Pain Relevance 0.17

In addition, expressions of P2X(3) and ASIC3 also increased in muscle afferent neurons in DRGs.

Positive_regulation (increased) of Gene_expression (expressions) of P2X in afferent neurons

16) Confidence 0.06 Published 2010 Journal Pain Section Abstract Doc Link 20378247 Disease Relevance 0.91 Pain Relevance 1.00

A memory for extracellular Ca2+ by speeding recovery of P2X receptors from desensitization.

Positive_regulation (recovery) of Gene_expression (recovery) of P2X associated with neuropeptide

17) Confidence 0.04 Published 1998 Journal J. Neurosci. Section Title Doc Link 9801363 Disease Relevance 0.10 Pain Relevance 0.34

Increased expression of CGRP, SP, P2X(3), and TRPV1 in the TG may be involved in the behavioral changes in this model.

Positive_regulation (Increased) of Gene_expression (expression) of P2X associated with substance p and calcitonin gene-related peptide

18) Confidence 0.03 Published 2006 Journal J Pain Section Abstract Doc Link 16942952 Disease Relevance 1.56 Pain Relevance 1.38

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