INT78234

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 12.86
Pain Relevance 12.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx2)
Anatomy Link Frequency
DRG 7
neurons 6
spinal cord 5
hippocampus 2
afferent neurons 2
P2rx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
allodynia 17 100.00 Very High Very High Very High
dorsal root ganglion 13 100.00 Very High Very High Very High
substance P 7 100.00 Very High Very High Very High
Calcitonin gene-related peptide 6 100.00 Very High Very High Very High
agonist 11 99.98 Very High Very High Very High
Neuritis 10 99.98 Very High Very High Very High
Cancer pain 4 99.92 Very High Very High Very High
Eae 11 99.72 Very High Very High Very High
Spinal cord 28 99.68 Very High Very High Very High
Pain 38 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 38 100.00 Very High Very High Very High
Ganglion Cysts 20 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 10 99.98 Very High Very High Very High
Cancer Pain 4 99.92 Very High Very High Very High
Injury 15 99.72 Very High Very High Very High
Mouth Cancer 4 99.72 Very High Very High Very High
Pain 26 99.12 Very High Very High Very High
Nociception 31 98.32 Very High Very High Very High
Nervous System Injury 8 98.28 Very High Very High Very High
INFLAMMATION 12 97.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, inflammation caused a twofold to threefold increase in both ATP-activated currents, altered the voltage dependence of P2X receptors, and enhanced the expression of P2X2 and P2X3 receptors.
Positive_regulation (enhanced) of Gene_expression (expression) of P2X2 associated with addiction and inflammation
1) Confidence 0.69 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11756492 Disease Relevance 0.89 Pain Relevance 0.68
A sample of mock-transfected cells was simultaneously probed with the P2X2 and P2X3 subunit-specific polyclonal antibodies
Positive_regulation (simultaneously) of Gene_expression (probed) of P2X2
2) Confidence 0.37 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.31
P2X(3) receptor antagonist A-317491 reduced P2X agonist activated currents and P2X(3) mRNA expression.
Positive_regulation (activated) of Gene_expression (expression) of P2X associated with antagonist and agonist
3) Confidence 0.26 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18158099 Disease Relevance 1.09 Pain Relevance 0.74
GABAA receptors mediated modulation of expression of both P2X2 and P2X4 receptors, which may play an important role in the regulation of seizure activity in the gerbil hippocampus [139].
Positive_regulation (mediated) of Gene_expression (expression) of P2X2 in hippocampus associated with convulsion and hippocampus
4) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.79 Pain Relevance 0.46
Overall, the present data demonstrate that activation of P2X(3) receptors contribute to the expression of chronic inflammatory and neuropathic pain states and that relief form these forms of chronic pain might be achieved by selective blockade of P2X(3 )receptor expression or activation.
Positive_regulation (activation) of Gene_expression (expression) of P2X associated with inflammation, lasting pain and neuropathic pain
5) Confidence 0.19 Published 2002 Journal Pain Section Abstract Doc Link 12237180 Disease Relevance 0.94 Pain Relevance 0.83
Formalin-induced increase in P2X(3) receptor expression in dorsal root ganglia: implications for nociception.
Positive_regulation (increase) of Gene_expression (expression) of P2X in dorsal root ganglia associated with nociception and nociceptor
6) Confidence 0.16 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 19473342 Disease Relevance 0.29 Pain Relevance 0.58
These data suggest that formalin injection leads to early upregulation of P2X(3) expression in the spinal cord and DRG and that this may be one of the mechanisms giving rise to nociception.
Positive_regulation (upregulation) of Gene_expression (expression) of P2X in spinal cord associated with nociception and spinal cord
7) Confidence 0.16 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19473342 Disease Relevance 0.17 Pain Relevance 0.17
Our data demonstrate that EAN induces mechanical allodynia and P2X(4)R expression in spinal microglia, suggesting that EAN is a good animal model for neuropathic pain in polyneuropathy and spinal microglia activation might participate in EAN-induced neuropathic pain.
Positive_regulation (induces) of Gene_expression (expression) of P2X in microglia associated with neuropathy, allodynia, neuropathic pain and neuritis
8) Confidence 0.15 Published 2008 Journal Neuroscience Section Abstract Doc Link 18276080 Disease Relevance 1.54 Pain Relevance 1.50
Expression of the P2X(3) transcript in the DRG was unchanged 30 min and 1 h after formalin injection, but increased after 12 h.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (Expression) of P2X in DRG
9) Confidence 0.13 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19473342 Disease Relevance 0.20 Pain Relevance 0.24
Expression of the P2X(3) transcript in the DRG was unchanged 30 min and 1 h after formalin injection, but increased after 12 h.
Positive_regulation (increased) of Gene_expression (Expression) of P2X in DRG
10) Confidence 0.13 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19473342 Disease Relevance 0.20 Pain Relevance 0.25
Taken together with the previous reports that P2X(3) expression increases in the spared DRG neurons in other neuropathic pain models, there appears to be differences in the phenotypic changes and pathomechanisms of the various neuropathic pain models.
Positive_regulation (increases) of Gene_expression (expression) of P2X in neurons associated with eae
11) Confidence 0.07 Published 2002 Journal Pain Section Abstract Doc Link 12237189 Disease Relevance 0.52 Pain Relevance 0.80
Expressions of TRPV2, P2X(3), and ASIC3 increased in all DRG neurons.
Positive_regulation (increased) of Gene_expression (Expressions) of P2X in neurons associated with dorsal root ganglion
12) Confidence 0.06 Published 2010 Journal Pain Section Abstract Doc Link 20378247 Disease Relevance 0.92 Pain Relevance 1.00
The expression of P2X(3) receptor in DRG neurons was increased after CCI.
Positive_regulation (increased) of Gene_expression (expression) of P2X in neurons associated with dorsal root ganglion and eae
13) Confidence 0.06 Published 2010 Journal Brain Res. Section Abstract Doc Link 19968976 Disease Relevance 1.65 Pain Relevance 1.26
We also found that the expression level of P2X(4) was increased strikingly in spinal cord microgila after nerve injury and that pharmacological blockade or inhibition of the expression of P2X(4) reversed the allodynia.
Positive_regulation (increased) of Gene_expression (expression) of P2X in spinal cord associated with nervous system injury, allodynia and spinal cord
14) Confidence 0.06 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14978347 Disease Relevance 0.91 Pain Relevance 1.06
These data suggest that formalin injection leads to early upregulation of P2X(3) expression in the spinal cord and DRG and that this may be one of the mechanisms giving rise to nociception.
Positive_regulation (upregulation) of in DRG Gene_expression (expression) of P2X in spinal cord associated with nociception and spinal cord
15) Confidence 0.06 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19473342 Disease Relevance 0.17 Pain Relevance 0.17
In addition, expressions of P2X(3) and ASIC3 also increased in muscle afferent neurons in DRGs.
Positive_regulation (increased) of Gene_expression (expressions) of P2X in afferent neurons
16) Confidence 0.06 Published 2010 Journal Pain Section Abstract Doc Link 20378247 Disease Relevance 0.91 Pain Relevance 1.00
A memory for extracellular Ca2+ by speeding recovery of P2X receptors from desensitization.
Positive_regulation (recovery) of Gene_expression (recovery) of P2X associated with neuropeptide
17) Confidence 0.04 Published 1998 Journal J. Neurosci. Section Title Doc Link 9801363 Disease Relevance 0.10 Pain Relevance 0.34
Increased expression of CGRP, SP, P2X(3), and TRPV1 in the TG may be involved in the behavioral changes in this model.
Positive_regulation (Increased) of Gene_expression (expression) of P2X associated with substance p and calcitonin gene-related peptide
18) Confidence 0.03 Published 2006 Journal J Pain Section Abstract Doc Link 16942952 Disease Relevance 1.56 Pain Relevance 1.38

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