INT78238

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Context Info
Confidence 0.36
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 0.87
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PDIA3) protein folding (PDIA3) signal transduction (PDIA3)
endoplasmic reticulum (PDIA3)
Anatomy Link Frequency
sympathetic 1
PDIA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 4 100.00 Very High Very High Very High
Opioid 7 69.44 Quite High
Limbic system 1 63.08 Quite High
chemokine 12 55.60 Quite High
dopamine receptor 6 22.24 Low Low
Dopamine 18 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
bradykinin 6 5.00 Very Low Very Low Very Low
opioid receptor 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 100.00 Very High Very High Very High
Adhesions 4 88.76 High High
Bordatella Infection 6 66.00 Quite High
Osteoarthritis 6 5.00 Very Low Very Low Very Low
Heart Rate Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It does not bind to DRG neurons treated with phosphatidylinositol-specific phospholipase C (PI-PLC) or to sympathetic neurons that do not express Ntm or other members of the IgLON family at significant levels.
PI-PLC Neg (not) Binding (bind) of in sympathetic associated with dorsal root ganglion
1) Confidence 0.36 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9801370 Disease Relevance 0.69 Pain Relevance 0.29
Such role for ERp57 wouldn't be exclusive for 7TM-Rs, as it was shown the MHC class I receptors that a calnexin/ERp57 complex is thought to facilitate the correct oxidation and folding of class I heavy chains into a conformation compatible with recognition by ?
ERp57 Binding (complex) of
2) Confidence 0.16 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0
2AR homodimer, ERp57 which interacts only with AT1R-containing dimers, and HSP70 which interacts weakly with both homodimers, but not the heterodimer.
ERp57 Binding (interacts) of
3) Confidence 0.16 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0.06 Pain Relevance 0.06
2AR homodimer, ERp57 which interacts only with AT1R-containing dimers, and HSP70 which interacts weakly with both homodimers, but not the heterodimer.
ERp57 Neg (not) Binding (heterodimer) of
4) Confidence 0.16 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0.07 Pain Relevance 0.10
Striking examples include the appearance of interaction of ERp57, calnexin with the ?
ERp57 Binding (interaction) of
5) Confidence 0.16 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0
Such role for ERp57 wouldn't be exclusive for 7TM-Rs, as it was shown the MHC class I receptors that a calnexin/ERp57 complex is thought to facilitate the correct oxidation and folding of class I heavy chains into a conformation compatible with recognition by ?
ERp57 Binding (role) of
6) Confidence 0.16 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0
2AR homodimer, ERp57 which interacts only with AT1R-containing dimers, and HSP70 which interacts weakly with both homodimers, but not the heterodimer.
ERp57 Binding (interacts) of
7) Confidence 0.16 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0.06 Pain Relevance 0.09

General Comments

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