INT7824

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Context Info
Confidence 0.62
First Reported 1982
Last Reported 2010
Negated 4
Speculated 6
Reported most in Abstract
Documents 39
Total Number 45
Disease Relevance 5.31
Pain Relevance 39.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck) DNA binding (Cck)
Anatomy Link Frequency
brain 6
mossy fiber 5
tail 2
hippocampal formation 1
plasma 1
Cck (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 546 100.00 Very High Very High Very High
agonist 61 100.00 Very High Very High Very High
narcan 46 100.00 Very High Very High Very High
Enkephalin 43 100.00 Very High Very High Very High
Dynorphin 29 100.00 Very High Very High Very High
Neuropeptide 18 100.00 Very High Very High Very High
Somatostatin 6 100.00 Very High Very High Very High
dopamine receptor 2 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
antagonist 123 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 16 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 6 100.00 Very High Very High Very High
Ganglion Cysts 3 98.56 Very High Very High Very High
Morphine Dependence 10 98.52 Very High Very High Very High
Epilepsy 6 96.68 Very High Very High Very High
Stress 9 96.12 Very High Very High Very High
Syndrome 5 85.68 High High
Opiate Addiction 5 85.00 Quite High
Hyperphagia 4 84.88 Quite High
Obesity 58 83.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the antianalgesic action of CCK was not affected by dynorphin antiserum.
Neg (not) Regulation (affected) of CCK associated with dynorphin and cholecystokinin
1) Confidence 0.62 Published 1999 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 10193446 Disease Relevance 0 Pain Relevance 1.73
In the present study, effect of cholecystokinin (CCK) agonists and on dependence to morphine in mice has been investigated.
Regulation (effect) of cholecystokinin associated with addiction, agonist, cholecystokinin and morphine
2) Confidence 0.45 Published 1997 Journal Pharmacol. Toxicol. Section Abstract Doc Link 9335069 Disease Relevance 0.14 Pain Relevance 0.98
In the present study, effect of cholecystokinin (CCK) agonists and on dependence to morphine in mice has been investigated.
Regulation (effect) of CCK associated with addiction, agonist, cholecystokinin and morphine
3) Confidence 0.45 Published 1997 Journal Pharmacol. Toxicol. Section Abstract Doc Link 9335069 Disease Relevance 0.14 Pain Relevance 0.98
In this work we have shown, by in vivo binding experiments, that the endogenous enkephalins, protected from degrading enzymes by mixed inhibitors such as kelatorphan and N-[(R,S)-2-benzyl-3-[(S)-2-amino-4-methylthiobutyldithio]-1-oxo pro pyl]- L-phenylalanine benzyl ester (RB 101), a systemically active prodrug, modulate CCK release in mouse brain, leading to an overall increase in the extracellular levels of CCK.
Regulation (modulate) of CCK in brain associated with enkephalin and cholecystokinin
4) Confidence 0.45 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1357099 Disease Relevance 0 Pain Relevance 0.69
Light microscopic immunocytochemical techniques were used to evaluate the influence of recurrent limbic seizure activity on the immunoreactivity for 3 neuropeptides--enkephalin, dynorphin, and cholecystokinin (CCK)--contained within the mouse hippocampal mossy fiber axonal system.
Regulation (influence) of CCK in mossy fiber associated with convulsion, dynorphin, neuropeptide, enkephalin and cholecystokinin
5) Confidence 0.45 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2898512 Disease Relevance 0.27 Pain Relevance 0.53
Light microscopic immunocytochemical techniques were used to evaluate the influence of recurrent limbic seizure activity on the immunoreactivity for 3 neuropeptides--enkephalin, dynorphin, and cholecystokinin (CCK)--contained within the mouse hippocampal mossy fiber axonal system.
Regulation (influence) of cholecystokinin in mossy fiber associated with convulsion, dynorphin, neuropeptide, enkephalin and cholecystokinin
6) Confidence 0.45 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2898512 Disease Relevance 0.27 Pain Relevance 0.53
Possible involvement of the CCK receptor in the benzodiazepine antagonism to CCK in the mouse brain.
Spec (Possible) Regulation (involvement) of CCK in brain associated with nociceptor
7) Confidence 0.45 Published 1987 Journal Jpn. J. Pharmacol. Section Title Doc Link 2883334 Disease Relevance 0.08 Pain Relevance 0.66
Possible involvement of the CCK receptor in the benzodiazepine antagonism to CCK in the mouse brain.
Spec (Possible) Regulation (involvement) of CCK in brain associated with nociceptor
8) Confidence 0.45 Published 1987 Journal Jpn. J. Pharmacol. Section Title Doc Link 2883334 Disease Relevance 0.08 Pain Relevance 0.65
In the present study, the effect of cholecystokinin agonists and antagonists on dependence to morphine in mice has been investigated.
Regulation (effect) of cholecystokinin associated with addiction, antagonist, agonist, cholecystokinin and morphine
9) Confidence 0.45 Published 1995 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8835359 Disease Relevance 0.15 Pain Relevance 1.08
Effects of cholecystokinin receptor agonist and antagonists on morphine dependence in mice.
Regulation (Effects) of cholecystokinin associated with addiction, antagonist, narcan, agonist, cholecystokinin and morphine
10) Confidence 0.45 Published 1995 Journal Pharmacol. Toxicol. Section Title Doc Link 8835359 Disease Relevance 0.23 Pain Relevance 1.57
Several differences between CCK-8-S and opioid substances included the need for relatively large doses of naloxone to block the effects of CCK-8-S in the phenylquinone-induced writhing test and the lack of effect of CCK-8-S in the tail-flick test.
Regulation (effects) of CCK-8-S in tail associated with tail-flick, narcan and opioid
11) Confidence 0.45 Published 1986 Journal Neuropharmacology Section Abstract Doc Link 3774112 Disease Relevance 0.17 Pain Relevance 0.62
The effects of a cholecystokinin agonist and antagonist on morphine antinociception in the tail-flick test have been evaluated. 2.
Regulation (effects) of cholecystokinin in tail associated with antinociception, antagonist, tail-flick, agonist, cholecystokinin and morphine
12) Confidence 0.45 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9013214 Disease Relevance 0 Pain Relevance 1.18
Effects of caerulein and CCK antagonists on tolerance induced to morphine antinociception in mice.
Regulation (Effects) of CCK associated with antinociception, antagonist, tolerance and morphine
13) Confidence 0.45 Published 1997 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 9264087 Disease Relevance 0 Pain Relevance 1.49
In the latter studies, a residual short-lasting analgesia in mice, treated with MK-329, was found to be resistant to naloxone (5 mg/kg), indicating its non-opioid nature and confirming the lack of effect of the CCK antagonist on opioid-independent analgesia.
Regulation (effect) of CCK associated with antagonist, narcan, opioid and analgesia
14) Confidence 0.45 Published 1989 Journal Neuropharmacology Section Abstract Doc Link 2812281 Disease Relevance 0 Pain Relevance 2.18
Differential effects of the CCK antagonist, MK-329, on analgesia induced by morphine, social conflict (opioid) and defeat experience (non-opioid) in male mice.
Regulation (effects) of CCK associated with antagonist, narcan, opioid, morphine and analgesia
15) Confidence 0.45 Published 1989 Journal Neuropharmacology Section Title Doc Link 2812281 Disease Relevance 0 Pain Relevance 1.91
These data suggest that heightened physiological activity, in the form of recurrent limbic seizures, induces long-lasting but quite different alterations in enkephalin and CCK concentration in the hippocampal mossy fiber system.
Regulation (alterations) of CCK in mossy fiber associated with convulsion and enkephalin
16) Confidence 0.45 Published 1988 Journal Peptides Section Abstract Doc Link 2856653 Disease Relevance 0.45 Pain Relevance 0.47
The aim of the present study was to determine the role of the apolipoprotein (apo) A-IV-cholecystokinin (CCK)(1) receptor (CCK(1)R) pathway in exogenous PYY(3-36)-induced activation of the gut-brain axis and inhibition of gastric emptying and food intake.
Spec (determine) Regulation (role) of CCK in brain associated with cholecystokinin and disorder of lipid metabolism
17) Confidence 0.44 Published 2007 Journal Endocrinology Section Abstract Doc Link 17641001 Disease Relevance 0.17 Pain Relevance 0.18
The aim of the present study was to determine the role of the apolipoprotein (apo) A-IV-cholecystokinin (CCK)(1) receptor (CCK(1)R) pathway in exogenous PYY(3-36)-induced activation of the gut-brain axis and inhibition of gastric emptying and food intake.
Spec (determine) Regulation (role) of CCK in brain associated with cholecystokinin and disorder of lipid metabolism
18) Confidence 0.44 Published 2007 Journal Endocrinology Section Abstract Doc Link 17641001 Disease Relevance 0.17 Pain Relevance 0.18
The data suggest a role for apo A-IV and the CCK(1)R in PYY(3-36)-induced activation of the vagal afferent pathway and inhibition of gastric emptying, but this is likely not the pathway mediating the effects of PYY(3-36) on food intake.
Regulation (role) of CCK associated with cholecystokinin
19) Confidence 0.44 Published 2007 Journal Endocrinology Section Abstract Doc Link 17641001 Disease Relevance 0.13 Pain Relevance 0.40
Cholecystokinin octapeptide, caerulein and caerulein analogues: effects on thermoregulation in the mouse.
Regulation (effects) of Cholecystokinin associated with cholecystokinin
20) Confidence 0.44 Published 1982 Journal Neuropharmacology Section Title Doc Link 6289160 Disease Relevance 0 Pain Relevance 0.34

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