INT78248

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 15.15
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a)
protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)
Anatomy Link Frequency
GALT 2
blood 1
blood vessel 1
nephron 1
tubule 1
Cdkn2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 22 99.64 Very High Very High Very High
Kinase C 3 99.32 Very High Very High Very High
dopamine receptor 5 97.16 Very High Very High Very High
opioid receptor 5 96.84 Very High Very High Very High
nud 1 96.44 Very High Very High Very High
Calcium channel 10 96.40 Very High Very High Very High
endometriosis 138 96.28 Very High Very High Very High
Morphine 2 93.72 High High
ischemia 40 93.46 High High
Clonidine 5 91.92 High High
Disease Link Frequency Relevance Heat
Acute Renal Failure 106 100.00 Very High Very High Very High
Nerve Sheath Neoplasms 39 98.88 Very High Very High Very High
Adenocarcinoma 64 98.48 Very High Very High Very High
Metastasis 57 98.48 Very High Very High Very High
Disorders Of Creatine Metabolism 30 98.34 Very High Very High Very High
Tetraploidy 1 98.20 Very High Very High Very High
Renal Failure 22 97.96 Very High Very High Very High
Aneuploidy 1 97.56 Very High Very High Very High
Ovarian Cancer 12 97.32 Very High Very High Very High
Cancer 353 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From these results, we conclude that reduction of the absorbed fraction of cyclosporin strongly contributes to the decrease in AUCpo in the presence of ARF.
Negative_regulation (decrease) of ARF associated with acute renal failure
1) Confidence 0.59 Published 1999 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10385211 Disease Relevance 0.74 Pain Relevance 0.13
Development of frank, metastatic tumors requires combination of expression of k-ras mutant or Ela-SV49TAg with the deficiency of the Ink4a/Arf gene [44,46,47].
Negative_regulation (deficiency) of Arf associated with metastasis
2) Confidence 0.42 Published 2006 Journal J Carcinog Section Body Doc Link PMC1559682 Disease Relevance 0.98 Pain Relevance 0
For instance, mice with both Cre-mediated k-ras mutation and Ink4a/Arf gene deficiency develop metastatic pancreatic ductal adenocarcinomas [44].
Negative_regulation (deficiency) of Arf associated with adenocarcinoma
3) Confidence 0.42 Published 2006 Journal J Carcinog Section Body Doc Link PMC1559682 Disease Relevance 0.72 Pain Relevance 0
At the same time point, expression of cyclin-dependent kinase inhibitor p16INK4 (CDKN2A) was upregulated (Table 2).
Negative_regulation (inhibitor) of p16INK4
4) Confidence 0.41 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.05 Pain Relevance 0
For ARF prevention, early recognition of pending deleterious compensatory changes is critical.
Negative_regulation (prevention) of ARF
5) Confidence 0.39 Published 1998 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 9801983 Disease Relevance 0.25 Pain Relevance 0.07
The area under the blood cyclosporin concentration-time curve after oral administration (AUCpo) were 4.976+/-0.847 mghL(-1) for ARF rats and 9.684+/-1.100 mghL(-1) for control rats; AUCpo in ARF was significantly reduced in a manner dependent on renal function.
Negative_regulation (reduced) of ARF in blood associated with acute renal failure
6) Confidence 0.38 Published 1999 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10385211 Disease Relevance 1.07 Pain Relevance 0.04
Many of the genetic lesions involved in BE neoplastic progression are known, including loss of CDKN2A (p16) and TP53 (p53) and the development of tetraploidy and aneuploidy.
Negative_regulation (loss) of CDKN2A associated with aneuploidy and tetraploidy
7) Confidence 0.30 Published 2006 Journal J Natl Compr Canc Netw Section Abstract Doc Link 16569389 Disease Relevance 0.70 Pain Relevance 0.12
These alterations include inactivation of cell-cycle associated genes such as TP53, RB1 and CDKN2A which encodes p16(INK4A) and p14(ARF) [16,17].
Negative_regulation (inactivation) of INK4A
8) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2924852 Disease Relevance 1.01 Pain Relevance 0.03
These alterations include inactivation of cell-cycle associated genes such as TP53, RB1 and CDKN2A which encodes p16(INK4A) and p14(ARF) [16,17].
Negative_regulation (inactivation) of p16
9) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2924852 Disease Relevance 1.01 Pain Relevance 0.03
These alterations include inactivation of cell-cycle associated genes such as TP53, RB1 and CDKN2A which encodes p16(INK4A) and p14(ARF) [16,17].
Negative_regulation (inactivation) of CDKN2A
10) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2924852 Disease Relevance 1.00 Pain Relevance 0.03
Various clinical trials have assessed the ability of different interventions to prevent ARF after CABG.
Negative_regulation (prevent) of ARF associated with acute renal failure
11) Confidence 0.25 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697583 Disease Relevance 0.71 Pain Relevance 0.07
Although no prior studies have evaluated whether allopurinol might prevent ARF in humans, the xanthine oxidase inhibitor oxypurinol did not prevent decreased renal function in rats, which may be because of the effect of oxypurinol to prevent the proliferation of nephron tubular cells.28 Similarly, in our study, the lack of effect of allopurinol on renal function may be related to drug antiproliferative effects on tubular cells.28
Spec (might) Negative_regulation (prevent) of ARF in nephron associated with acute renal failure
12) Confidence 0.25 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697583 Disease Relevance 0.52 Pain Relevance 0.10
The antioxidant N-acetylcysteine was found to have no effect in preventing ARF in cardiac patients,35 or in reducing the rate of renal failure in patients undergoing heart and/or aortic surgery.36–38 The renal function of on-pump CABG patients was improved by leukodepletion, which prevented tubule destruction,39 and infusion of sodium nitroprusside resulted in improved renal function in cardiac patients.40 As hydration prior to surgery has been found to prevent renal damage,41 our patients were infused with 1–2 L of normal saline to prevent confounding the effects of dehydration with those of allopurinol and vitamin E.
Negative_regulation (preventing) of ARF in tubule associated with acute renal failure, renal failure and volume depletion and dehydration
13) Confidence 0.18 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697583 Disease Relevance 0.63 Pain Relevance 0.09
The selective dopamine receptor fenoldopam has been found to maintain creatinine clearance in the 0–4 h and 4–8 h intervals after CABG.44 Although dopamine has been used to prevent ARF, this drug has not been shown to have any effect.19,45,46 The ability of the ?
Negative_regulation (prevent) of ARF associated with acute renal failure, dopamine, disorders of creatine metabolism and dopamine receptor
14) Confidence 0.18 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697583 Disease Relevance 0.63 Pain Relevance 0.23
Acute renal failure (ARF) is a common and dangerous complication of cardiac surgery, especially after surgery for cardiac coronary artery bypass graft (CABG),1 obstructive jaundice,2 and aortic aneurysm.3 ARF frequently arises because of decreased tissue perfusion, ischemia, adverse effects of free radicals,4 and blood vessel constriction stimulating the release of angiotensins such as endothelins.5 ARF following CABG has been found to increase mortality, morbidity, and intensive care unit (ICU) stay, with some patients requiring dialysis.6,7 To date, no effective prophylaxis has been found to prevent ARF.
Negative_regulation (prevent) of ARF in blood vessel associated with acute renal failure, ischemia, aneurism and obstructive jaundice
15) Confidence 0.18 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697583 Disease Relevance 1.10 Pain Relevance 0.18
Goumenou et al. [35], by microsatellite analysis, demonstrated that loss of heterozygosity on p16(Ink4), GALT, and p53, as well as on APOA2, a region frequently lost in ovarian cancer, occurs in endometriosis, even in stage II of the disease.
Negative_regulation (loss) of Ink4 in GALT associated with endometriosis, ovarian cancer and disease
16) Confidence 0.16 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 1.66 Pain Relevance 0.45
Goumenou et al. [35], by microsatellite analysis, demonstrated that loss of heterozygosity on p16(Ink4), GALT, and p53, as well as on APOA2, a region frequently lost in ovarian cancer, occurs in endometriosis, even in stage II of the disease.
Negative_regulation (loss) of p16 in GALT associated with endometriosis, ovarian cancer and disease
17) Confidence 0.16 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 1.66 Pain Relevance 0.45
In RG2 cells, the genes of p53 and p16 are impaired and exhibit homologous deletion, and these were undetectable in immunoblotting analysis.
Negative_regulation (impaired) of p16 in RG2
18) Confidence 0.08 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.69 Pain Relevance 0
The DAMGO-mediated PLD2 activation was inhibited by brefeldin A, an inhibitor of ADP-ribosylation factor (ARF) but not by the protein kinase C (PKC) inhibitor calphostin C indicating that opioid receptor-mediated activation of PLD2 is ARF- but not PKC-dependent.
Negative_regulation (inhibitor) of ARF associated with kinase c and opioid receptor
19) Confidence 0.08 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.77
In addition, allelic losses of tumor suppressor genes p16 (INK4, CDKN2A) and DPC4 (MADH4, SMAD4) were detected by monitoring the loss of heterozygosity (LOH) at 9p and 18q, respectively.
Negative_regulation (losses) of CDKN2A
20) Confidence 0.07 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17659731 Disease Relevance 0 Pain Relevance 0

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