INT78253

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Context Info
Confidence 0.77
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 10
Disease Relevance 1.49
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Npy2r) plasma membrane (Npy2r) signal transducer activity (Npy2r)
Anatomy Link Frequency
dorsal horn 2
jejunum 1
colon 1
neuron 1
skin 1
Npy2r (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 27 99.98 Very High Very High Very High
dorsal rhizotomy 3 99.92 Very High Very High Very High
spinal dorsal horn 2 99.68 Very High Very High Very High
interneuron 2 96.92 Very High Very High Very High
Dorsal horn neuron 14 94.32 High High
Spinal cord 6 93.44 High High
Dorsal horn 8 92.68 High High
intrathecal 8 91.36 High High
Inflammation 2 90.84 High High
Calcitonin gene-related peptide 3 89.92 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 19 94.72 High High
Nociception 6 92.60 High High
INFLAMMATION 2 90.84 High High
Nervous System Injury 2 90.16 High High
Ganglion Cysts 1 75.00 Quite High
Sprains And Strains 1 66.56 Quite High
Pain 6 51.36 Quite High
Body Weight 4 12.72 Low Low
Diabetes Mellitus 4 7.60 Low Low
Adhesions 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Y2R-L1 was also detected on the skin, more abundantly in hairy than glabrous skin.
Gene_expression (detected) of Y2R in skin
1) Confidence 0.77 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 16025447 Disease Relevance 0.15 Pain Relevance 0.39
Specificity experiments showed complete disappearance of the Y2R-LI described above after incubation with antibody preadsorbed with the immunogenic peptide.
Gene_expression (disappearance) of Y2R
2) Confidence 0.67 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 16025447 Disease Relevance 0.17 Pain Relevance 0.39
Neuropeptide Y2 receptor protein is present in peptidergic and nonpeptidergic primary sensory neurons of the mouse.
Gene_expression (present) of Y2 receptor in primary sensory neurons associated with neuropeptide
3) Confidence 0.52 Published 2005 Journal J. Comp. Neurol. Section Title Doc Link 16025447 Disease Relevance 0.11 Pain Relevance 0.37
Y1- and Y2-R mRNAs were found mainly in small DRG neuron profiles.
Gene_expression (found) of Y2-R in neuron
4) Confidence 0.15 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9802405 Disease Relevance 0.28 Pain Relevance 0.28
In rat jejunum and colon Y2 expression occurs in epithelial and muscle layers [28] but as yet no immunohistochemical Y2-receptor localization in the intestine has been described.
Gene_expression (expression) of Y2 in jejunum
5) Confidence 0.12 Published 2008 Journal Nutrition Section Body Doc Link PMC2572019 Disease Relevance 0 Pain Relevance 0.06
Measurement of ion transport and Y1 and Y2 absorptive tone in isolated mucosal preparations
Gene_expression (tone) of Y2
6) Confidence 0.10 Published 2008 Journal Nutrition Section Body Doc Link PMC2572019 Disease Relevance 0.15 Pain Relevance 0
Therefore, we set out to establish whether endogenous PYY was responsible for Y1 absorptive tone and NPY-mediated Y2 tone, making use of single (PYY?
Gene_expression (tone) of Y2
7) Confidence 0.10 Published 2008 Journal Nutrition Section Body Doc Link PMC2572019 Disease Relevance 0.09 Pain Relevance 0
Y1R and NPY receptor type 2 (Y2R) are present in the spinal dorsal horn presynaptically on primary afferent, and possibly interneuron terminals, but only Y1R is found postsynaptically on dorsal horn neurons.
Gene_expression (present) of Y2R in dorsal horn associated with spinal dorsal horn, interneuron and dorsal horn neuron
8) Confidence 0.06 Published 2009 Journal Neuroscience Section Abstract Doc Link 19138726 Disease Relevance 0.27 Pain Relevance 0.66
In rat jejunum and colon Y2 expression occurs in epithelial and muscle layers [28] but as yet no immunohistochemical Y2-receptor localization in the intestine has been described.
Gene_expression (expression) of Y2 in colon
9) Confidence 0.04 Published 2008 Journal Nutrition Section Body Doc Link PMC2572019 Disease Relevance 0 Pain Relevance 0.06
Y1R and NPY receptor type 2 (Y2R) are present in the spinal dorsal horn presynaptically on primary afferent, and possibly interneuron terminals, but only Y1R is found postsynaptically on dorsal horn neurons.
Gene_expression (present) of NPY receptor type 2 in dorsal horn associated with spinal dorsal horn, interneuron and dorsal horn neuron
10) Confidence 0.03 Published 2009 Journal Neuroscience Section Abstract Doc Link 19138726 Disease Relevance 0.27 Pain Relevance 0.67

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