INT78254

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Context Info
Confidence 0.54
First Reported 1998
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 2.59
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Tap2) endoplasmic reticulum (Tap2) ATPase activity (Tap2)
plasma membrane (Tap2) nucleus (Tap2) protein complex assembly (Tap2)
Anatomy Link Frequency
medial 1
spleens 1
Tap2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 1 93.40 High High
Analgesic 1 91.96 High High
Pain 2 89.84 High High
alcohol 1 79.24 Quite High
Neuropeptide 4 75.00 Quite High
dorsal root ganglion 1 75.00 Quite High
Root ganglion neuron 1 75.00 Quite High
tail-flick 1 53.76 Quite High
spinal inflammation 7 50.00 Quite Low
Sciatic nerve 1 42.56 Quite Low
Disease Link Frequency Relevance Heat
Pox Virus Infection 90 99.42 Very High Very High Very High
Sleep Disorders 6 99.20 Very High Very High Very High
Infection 114 98.04 Very High Very High Very High
Viral Infection 30 96.88 Very High Very High Very High
Vesicular Stomatitis 24 95.36 Very High Very High Very High
Pain 2 89.84 High High
Targeted Disruption 1 87.56 High High
Sprains And Strains 49 82.36 Quite High
Anxiety Disorder 1 78.88 Quite High
Ganglion Cysts 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: A total of 169 patients (142 males, 27 females) were included, comprising 47 JAS and 122 AAS patients.
Gene_expression (comprising) of JAS
1) Confidence 0.54 Published 2009 Journal J Chin Med Assoc Section Body Doc Link 19948434 Disease Relevance 0 Pain Relevance 0
Local microinjection of NPY exhibited the strongest potentiating effect on pentobarbital-induced sedation in the posterior hypothalamic area and Y1 expression was found in the dorsal-premammillary and medial part of medial mammillary nuclei.
Gene_expression (expression) of Y1 in medial associated with sleep disorders
2) Confidence 0.43 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11454027 Disease Relevance 0.77 Pain Relevance 0.24
These findings suggest that expression, regulation, localization and possible function of Y1- and Y2-Rs are not dependent on presence of the endogenous ligand.
Gene_expression (expression) of Y1
3) Confidence 0.41 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9802405 Disease Relevance 0.25 Pain Relevance 0.32
Increased expression of mouse TAP1 appeared to be as effective as increased expression of human TAP1 and TAP2 in raising the level of MHC class I complexes (H-2Kb–SIINFEKL) on the cell surface.
Gene_expression (expression) of TAP2
4) Confidence 0.41 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.14 Pain Relevance 0
T2 cells negative for TAP1 and TAP2 and transfected with mouse H-2Kb were a gift from Peter Cresswell, (Yale University, New Haven, Connecticut, United States).


Neg (negative) Gene_expression (negative) of TAP2
5) Confidence 0.35 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.15 Pain Relevance 0
RT-PCR was used to detect human TAP1 and TAP2, and mouse TAP1 and TAP2, in spleens 24 h after infection.
Gene_expression (detect) of TAP2 in spleens associated with infection
6) Confidence 0.32 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.25 Pain Relevance 0
Human TAP1 protein was detected in splenocytes by immunoblotting (Figure 4A), and RT-PCR analysis showed that both human TAP1 and human TAP2 mRNA were present (Figure 4B).
Gene_expression (present) of TAP2 mRNA
7) Confidence 0.32 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.33 Pain Relevance 0
An expression system using recombinant vaccinia virus (VV) was used to over-express human TAP1 and TAP2 (VV-hTAP1,2) in normal mice.
Gene_expression (express) of TAP2 associated with pox virus infection
8) Confidence 0.32 Published 2005 Journal PLoS Pathogens Section Abstract Doc Link PMC1323471 Disease Relevance 0.36 Pain Relevance 0
Using the TAP Component of the Antigen-Processing Machinery as a Molecular Adjuvant

We hypothesize that over-expression of transporters associated with antigen processing (TAP1 and TAP2), components of the major histocompatibility complex (MHC) class I antigen-processing pathway, enhances antigen-specific cytotoxic activity in response to viral infection.

Gene_expression (expression) of TAP2 associated with viral infection
9) Confidence 0.32 Published 2005 Journal PLoS Pathogens Section Title Doc Link PMC1323471 Disease Relevance 0.35 Pain Relevance 0

General Comments

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