INT78256

Context Info Confidence 0.28 First Reported 1998 Last Reported 2005 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.38 Pain Relevance 0.32

transport (Tap2) endoplasmic reticulum (Tap2) ATPase activity (Tap2) plasma membrane (Tap2) nucleus (Tap2) protein complex assembly (Tap2)

Tap2 (Mus musculus)

Pain Link Frequency Relevance Heat Analgesic 1 91.96 Pain 1 89.84 Neuropeptide 2 75.00 dorsal root ganglion 1 75.00 Root ganglion neuron 1 75.00 tail-flick 1 53.76 Sciatic nerve 1 42.56 Potency 2 5.00 anesthesia 1 5.00 adenocard 1 5.00

Disease Link Frequency Relevance Heat Pain 1 89.84 Infection 19 87.08 Sprains And Strains 9 82.36 Ganglion Cysts 1 75.00 Viral Infection 5 50.40 Nociception 1 50.00 Pox Virus Infection 15 5.00 Vesicular Stomatitis 4 5.00 Weight Loss 3 5.00 Toxicity 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These findings suggest that expression, regulation, localization and possible function of Y1- and Y2-Rs are not dependent on presence of the endogenous ligand.

Neg (not) Regulation (dependent) of Gene_expression (expression) of Y1

1) Confidence 0.28 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9802405 Disease Relevance 0.25 Pain Relevance 0.32

Increased expression of mouse TAP1 appeared to be as effective as increased expression of human TAP1 and TAP2 in raising the level of MHC class I complexes (H-2Kb–SIINFEKL) on the cell surface.

Regulation (effective) of Gene_expression (expression) of TAP2

2) Confidence 0.24 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.14 Pain Relevance 0

General Comments

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