INT7826

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.15
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck) DNA binding (Cck)
Anatomy Link Frequency
brain 2
Cck (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 121 100.00 Very High Very High Very High
antagonist 23 100.00 Very High Very High Very High
Kinase C 1 99.28 Very High Very High Very High
antinociception 4 99.16 Very High Very High Very High
Antinociceptive 2 99.10 Very High Very High Very High
Enkephalin 8 98.92 Very High Very High Very High
narcan 6 96.32 Very High Very High Very High
Kappa opioid receptor 1 95.88 Very High Very High Very High
agonist 7 95.64 Very High Very High Very High
opioid receptor 4 93.04 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 92.80 High High
Anxiety Disorder 1 59.32 Quite High
Body Weight 2 45.44 Quite Low
Appetite Loss 1 41.68 Quite Low
Aids-related Complex 5 40.36 Quite Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The stimulation of CCK(A) receptors seems to increase the release of endogenous enkephalins.
Spec (seems) Positive_regulation (increase) of Positive_regulation (stimulation) of CCK associated with enkephalin and cholecystokinin
1) Confidence 0.50 Published 1999 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 10082226 Disease Relevance 0 Pain Relevance 1.41
The action of CCK on CART expression was shown to be mediated by activation of protein kinase C and cAMP response element binding protein (CREB) and was inhibited by orexigenic ghrelin [25].
Positive_regulation (mediated) of Positive_regulation (action) of CCK associated with kinase c and cholecystokinin
2) Confidence 0.48 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.15 Pain Relevance 0.71
In this work we have shown, by in vivo binding experiments, that the endogenous enkephalins, protected from degrading enzymes by mixed inhibitors such as kelatorphan and N-[(R,S)-2-benzyl-3-[(S)-2-amino-4-methylthiobutyldithio]-1-oxo pro pyl]- L-phenylalanine benzyl ester (RB 101), a systemically active prodrug, modulate CCK release in mouse brain, leading to an overall increase in the extracellular levels of CCK.
Positive_regulation (leading) of Positive_regulation (increase) of CCK in brain associated with enkephalin and cholecystokinin
3) Confidence 0.47 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1357099 Disease Relevance 0 Pain Relevance 0.76
The antinociceptive activity of SNF9007 was not a result of the activation of CCK receptors, as treatment with either CCK-A or CCK-B receptor antagonist was ineffective in blocking SNF9007 antinociception.
Positive_regulation (ineffective) of Positive_regulation (activation) of CCK associated with antinociception, antagonist and antinociceptive
4) Confidence 0.40 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8182541 Disease Relevance 0 Pain Relevance 1.40

General Comments

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