INT7827

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Context Info
Confidence 0.48
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 32
Total Number 32
Disease Relevance 4.66
Pain Relevance 23.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck) DNA binding (Cck)
Anatomy Link Frequency
brain 6
Plasma 1
ileum 1
tail 1
brainstem 1
Cck (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 559 100.00 Very High Very High Very High
Enkephalin 32 100.00 Very High Very High Very High
Endocannabinoid 7 100.00 Very High Very High Very High
agonist 22 99.88 Very High Very High Very High
Opioid 30 99.80 Very High Very High Very High
opiate 3 99.80 Very High Very High Very High
Morphine 65 99.76 Very High Very High Very High
amygdala 5 99.70 Very High Very High Very High
medulla 108 99.68 Very High Very High Very High
Delta opioid receptors 10 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 43 99.92 Very High Very High Very High
Neuropathic Pain 14 99.38 Very High Very High Very High
Anxiety Disorder 21 99.28 Very High Very High Very High
Morphine Dependence 2 99.28 Very High Very High Very High
Cognitive Disorder 8 98.38 Very High Very High Very High
Gastric Motility Disorder 2 97.84 Very High Very High Very High
Pain 10 97.68 Very High Very High Very High
Amnesia 3 93.48 High High
Nociception 5 90.84 High High
Appetite Loss 6 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that CCK mechanism(s) may be involved in morphine dependence, and dopaminergic mechanism(s) may interact with CCK in attenuation of naloxone-induced jumping.
CCK Binding (interact) of associated with addiction, narcan, cholecystokinin and morphine
1) Confidence 0.48 Published 1997 Journal Pharmacol. Toxicol. Section Abstract Doc Link 9335069 Disease Relevance 0.23 Pain Relevance 1.42
This was quantified by measuring the effects of both inhibitors on the in vivo binding of [3H]propionyl-Tyr(SO3H)-gNle-mGly-Trp-(N-Me)Nle-Asp-Phe-NH2 ([3H]pBC 264), a selective and highly potent CCK-B agonist.
CCK Binding (binding) of associated with agonist and cholecystokinin
2) Confidence 0.48 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1357099 Disease Relevance 0 Pain Relevance 0.85
CCK8-induced antinociception and satiety were significantly reversed by ATM in those doses. [125I]CCK8 binding to the brain slices was observed autoradiographically.
CCK8 Binding (binding) of in brain associated with antinociception
3) Confidence 0.48 Published 1989 Journal Brain Res. Section Abstract Doc Link 2720404 Disease Relevance 0 Pain Relevance 0.60
Comparison of the binding of [125I]CCK8 to the brain slices in the presence and the absence of ATM revealed that ATM (10(-6) M) clearly displaced the CCK8 binding in the various regions, especially in the cortex, of the brain.
CCK8 Binding (binding) of in brain
4) Confidence 0.48 Published 1989 Journal Brain Res. Section Abstract Doc Link 2720404 Disease Relevance 0 Pain Relevance 0.57
Anthramycin (ATM) which is a product of some streptomyces micro-organisms was shown to antagonize the central effects of cholecystokinin (CCK) such as antinociception and satiety and to displace CCK bound to the slices from the brains of mice.
CCK Binding (bound) of in brains associated with antinociception and cholecystokinin
5) Confidence 0.48 Published 1989 Journal Brain Res. Section Abstract Doc Link 2720404 Disease Relevance 0 Pain Relevance 0.53
[Manifestations of the antinociceptive and anxiolytic properties of the compound GB-115: interactions of cholecystokinin and opioid systems].
cholecystokinin Binding (interactions) of associated with analgesic, anxiety disorder, opioid, cholecystokinin and antinociceptive
6) Confidence 0.48 Published 2007 Journal Eksp Klin Farmakol Section Title Doc Link 17523442 Disease Relevance 0.59 Pain Relevance 1.00
RATIONALE: Cholecystokinin (CCK) interacts with the endopioid system in the regulation of various physiological functions, including the control of pain sensitivity, motor activity and emotional behaviour.
Cholecystokinin Binding (interacts) of associated with pain and cholecystokinin
7) Confidence 0.48 Published 2003 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 12545332 Disease Relevance 0.25 Pain Relevance 0.30
RATIONALE: Cholecystokinin (CCK) interacts with the endopioid system in the regulation of various physiological functions, including the control of pain sensitivity, motor activity and emotional behaviour.
CCK Binding (interacts) of associated with pain and cholecystokinin
8) Confidence 0.48 Published 2003 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 12545332 Disease Relevance 0.25 Pain Relevance 0.30
Stress-induced analgesia in mice: evidence for interaction between endocannabinoids and cholecystokinin.
cholecystokinin Binding (interaction) of associated with endocannabinoid, cholecystokinin and analgesia
9) Confidence 0.41 Published 2008 Journal Eur. J. Neurosci. Section Title Doc Link 18412633 Disease Relevance 0.27 Pain Relevance 1.82
This data suggests that the memory enhancement produced by peripherally administered CCK-8 involves the amygdala and that both CCK-8 and epinephrine interact with opioid amnestic mechanisms within the amygdala to alter memory processing.
CCK-8 Binding (interact) of in amygdala associated with cognitive disorder, opioid and amygdala
10) Confidence 0.40 Published 1992 Journal Brain Res. Section Abstract Doc Link 1511338 Disease Relevance 0.36 Pain Relevance 0.59
The anti-analgesic effect of APGPR may be mediated by CCK release, since APGPR does not have affinity for CCK receptors.
CCK Neg (not) Binding (affinity) of associated with analgesic
11) Confidence 0.37 Published 2008 Journal Peptides Section Abstract Doc Link 18304696 Disease Relevance 0.08 Pain Relevance 0.69
Characterization of SNF 9007, a novel cholecystokinin/opoid ligand in mouse ileum in vitro: evidence for involvement of cholecystokininA and cholecystokininB receptors in regulation of ion transport.
cholecystokinin Binding (Characterization) of in ileum associated with cholecystokinin
12) Confidence 0.37 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8113956 Disease Relevance 0 Pain Relevance 0.44
Experiment 1 was undertaken to determine whether i.p. injections of CCK8 or CCK4 can influence STR.
CCK4 Binding (injections) of
13) Confidence 0.37 Published 2001 Journal Peptides Section Abstract Doc Link 11457524 Disease Relevance 0 Pain Relevance 0.64
Experiment 1 was undertaken to determine whether i.p. injections of CCK8 or CCK4 can influence STR.
CCK8 Binding (injections) of
14) Confidence 0.37 Published 2001 Journal Peptides Section Abstract Doc Link 11457524 Disease Relevance 0 Pain Relevance 0.64
Cholecystokinin (CCK) and enkephalins appear to be colocalized in several brain structures, and a physiological interaction between these peptides has been suggested by a large number of pharmacological studies.
CCK Binding (interaction) of in brain structures associated with enkephalin and cholecystokinin
15) Confidence 0.37 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1357099 Disease Relevance 0 Pain Relevance 0.57
Cholecystokinin (CCK) and enkephalins appear to be colocalized in several brain structures, and a physiological interaction between these peptides has been suggested by a large number of pharmacological studies.
Cholecystokinin Binding (interaction) of in brain structures associated with enkephalin and cholecystokinin
16) Confidence 0.37 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1357099 Disease Relevance 0 Pain Relevance 0.57
CCK8s and its fragments given i.t. attenuated i.c.v. beta-endorphin-induced tail-flick inhibition with different potencies and efficacies.
CCK8s Binding (attenuated) of in tail associated with tail-flick
17) Confidence 0.37 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1545380 Disease Relevance 0 Pain Relevance 1.10
Stimulation of delta-opioid receptors reduces the in vivo binding of the cholecystokinin (CCK)-B-selective agonist [3H]pBC 264: evidence for a physiological regulation of CCKergic systems by endogenous enkephalins.
CCK Binding (binding) of associated with analgesic, agonist, enkephalin, delta opioid receptors and cholecystokinin
18) Confidence 0.36 Published 1992 Journal J. Neurochem. Section Title Doc Link 1357099 Disease Relevance 0 Pain Relevance 0.93
Stimulation of delta-opioid receptors reduces the in vivo binding of the cholecystokinin (CCK)-B-selective agonist [3H]pBC 264: evidence for a physiological regulation of CCKergic systems by endogenous enkephalins.
cholecystokinin Binding (binding) of associated with analgesic, agonist, enkephalin, delta opioid receptors and cholecystokinin
19) Confidence 0.36 Published 1992 Journal J. Neurochem. Section Title Doc Link 1357099 Disease Relevance 0 Pain Relevance 0.93
For Fos immunohistochemical processing, overnight fasted mice (n = 5 mice/group) were treated: a/i.c.v. with saline, b/i.p. with CCK-8 (0.4 ?
CCK-8 Binding (i.p.) of associated with cholecystokinin
20) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.22

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