INT7828

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Context Info
Confidence 0.69
First Reported 1987
Last Reported 2010
Negated 5
Speculated 3
Reported most in Abstract
Documents 55
Total Number 58
Disease Relevance 14.11
Pain Relevance 42.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprd1) plasma membrane (Oprd1) cytoplasm (Oprd1)
signal transducer activity (Oprd1)
Anatomy Link Frequency
brain 2
NG108-15 2
oocytes 2
PAG 1
DCs 1
Oprd1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 307 100.00 Very High Very High Very High
agonist 102 100.00 Very High Very High Very High
Opioid 74 100.00 Very High Very High Very High
Enkephalin 64 100.00 Very High Very High Very High
Delta opioid receptors 42 100.00 Very High Very High Very High
antinociception 28 100.00 Very High Very High Very High
Analgesic 25 100.00 Very High Very High Very High
dopamine receptor 6 100.00 Very High Very High Very High
Nucleus accumbens 8 99.92 Very High Very High Very High
Cholecystokinin 23 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 62 100.00 Very High Very High Very High
Neuropathic Pain 14 99.58 Very High Very High Very High
Diabetes Mellitus 48 99.52 Very High Very High Very High
Hypoxia 26 99.12 Very High Very High Very High
Urological Neuroanatomy 20 99.00 Very High Very High Very High
Stress 10 98.80 Very High Very High Very High
Injury 4 98.80 Very High Very High Very High
Pain 32 98.32 Very High Very High Very High
INFLAMMATION 6 95.92 Very High Very High Very High
Convulsion 18 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Delta opioid receptor activation is protective during hypoxic injury.
Positive_regulation (activation) of Delta opioid receptor associated with hypoxia, injury and opioid receptor
1) Confidence 0.69 Published 1996 Journal Neuroscience Section Abstract Doc Link 9157323 Disease Relevance 0.57 Pain Relevance 0.26
The levels of delta-opioid receptor mRNA are not modified during development in knock-out mice compared to wild-type, but are increased in adult caudate putamen (+39%, P<0.05) and nucleus accumbens (+66%, P<0.05) at a time when these receptors are believed to be functional.
Neg (not) Positive_regulation (increased) of delta-opioid receptor in nucleus accumbens associated with targeted disruption, nucleus accumbens and opioid receptor
2) Confidence 0.60 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044478 Disease Relevance 0.45 Pain Relevance 0.79
Even if the propensity of knock-out mice to show increased rewarding properties to morphine seems to be mainly due to the substantial and further increase in hyperdopaminergic activity following drug treatment, the involvement of increased delta-opioid receptor mRNA levels in this behavior remains to be elucidated.
Positive_regulation (increased) of delta-opioid receptor associated with targeted disruption, opioid receptor and morphine
3) Confidence 0.60 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044478 Disease Relevance 0.38 Pain Relevance 0.54
Saturation curves and Scatchard plots of [3H]2-D-alanine-5-D-leucine enkephalin binding revealed that the opioid delta receptor density in adult El mice during interictal periods was significantly increased in the cerebral cortex, hippocampus, and septal area.
Positive_regulation (increased) of opioid delta receptor in hippocampus associated with hippocampus, enkephalin, cerebral cortex and opioid
4) Confidence 0.50 Published 1989 Journal Neurochem. Res. Section Abstract Doc Link 2540443 Disease Relevance 0.66 Pain Relevance 0.61
The present data demonstrate a deficiency in delta1 and delta2 opioid antinociception in CXBK mice concomitant with reductions in whole-brain delta2 receptor binding and regional increases in DOR-1.
Positive_regulation (increases) of DOR-1 in brain associated with antinociception and opioid
5) Confidence 0.49 Published 1998 Journal Brain Res. Section Abstract Doc Link 9733948 Disease Relevance 0.39 Pain Relevance 1.00
OBJECTIVES: We have used opioid receptor knockout mice to determine whether the in vivo intrathecal (i.t.) pharmacological potency of delta, kappa, and bivalent kappa/delta ligands is altered in the absence of the KOR-1 and/or DOR-1 genes.
Spec (whether) Positive_regulation (absence) of DOR-1
6) Confidence 0.49 Published 2010 Journal Psychopharmacology (Berl.) Section Body Doc Link 20333506 Disease Relevance 0 Pain Relevance 0
DOR mRNA levels in selected CNS regions which either mediate antinociception; medial thalamus (MThal), periaqueductal gray (PAG), frontal cortex (FCtx) and spinal cord (SpC) or exhibit relatively high levels of DOR mRNA; nucleus accumbens (Acb) and caudate-putamen (CPu) were then quantitated by solution hybridization.
Positive_regulation (levels) of DOR mRNA in CNS associated with thalamus, opioid receptor, central grey, spinal cord, antinociception, nucleus accumbens, central nervous system and urological neuroanatomy
7) Confidence 0.47 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9379841 Disease Relevance 0.37 Pain Relevance 1.23
It is possible that increased activity of the delta opioid receptor system is one such adaptation.
Spec (possible) Positive_regulation (increased) of delta opioid receptor associated with opioid receptor
8) Confidence 0.46 Published 1996 Journal Neuroscience Section Abstract Doc Link 9157323 Disease Relevance 0.67 Pain Relevance 0.32
These findings indicate the functional coupling between the opioid delta-receptor and phospholipase C through an activation of Gi.
Positive_regulation (activation) of opioid delta-receptor associated with opioid
9) Confidence 0.46 Published 1993 Journal FEBS Lett. Section Abstract Doc Link 8224200 Disease Relevance 0 Pain Relevance 0.53
In conclusion, TAN-67 produced an antinociceptive effect through the activation of delta 1-opioid receptors.
Positive_regulation (activation) of delta 1-opioid associated with opioid receptor and antinociceptive
10) Confidence 0.46 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7781682 Disease Relevance 0.61 Pain Relevance 0.89
Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment.
Positive_regulation (Induction) of delta-opioid receptor in midbrain associated with midbrain, opioid receptor and morphine
11) Confidence 0.45 Published 2005 Journal J. Neurosci. Section Title Doc Link 15788776 Disease Relevance 0.32 Pain Relevance 1.15
Delta-opioid receptor (DOPr) activation fails to produce cellular physiological responses in many brain regions, including the periaqueductal gray (PAG), despite neural expression of high densities of the receptor.
Positive_regulation (activation) of Delta-opioid receptor in neural associated with opioid receptor and central grey
12) Confidence 0.45 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15788776 Disease Relevance 0.26 Pain Relevance 0.70
Functional interaction among opioid receptor types: up-regulation of mu- and delta-opioid receptor functions after repeated stimulation of kappa-opioid receptors.
Positive_regulation (up-regulation) of delta-opioid receptor associated with kappa opioid receptor and opioid receptor
13) Confidence 0.45 Published 2004 Journal Neuropharmacology Section Title Doc Link 14975677 Disease Relevance 0 Pain Relevance 0.90
Furthermore, the enhanced CWSS-induced antinociception in diabetic mice may be due to the activation of delta 1-opioid receptors.
Positive_regulation (activation) of 1-opioid associated with stress, antinociception, diabetes mellitus and opioid receptor
14) Confidence 0.43 Published 1994 Journal Life Sci. Section Abstract Doc Link 8196487 Disease Relevance 1.84 Pain Relevance 1.08
These structures show an unaltered response to delta2-receptor agonists and an augmented response to delta1-receptor agonists.
Positive_regulation (response) of delta1-receptor associated with agonist
15) Confidence 0.43 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11359522 Disease Relevance 0.21 Pain Relevance 0.67
These studies demonstrate that improgan analgesia does not require intact MOR-1, DOR-1, or KOR-1 genes, and support the hypothesis that improgan-like analgesics act in the CNS by non-opioid mechanisms.
Neg (not) Positive_regulation (require) of DOR-1 associated with analgesic, opioid and analgesia
16) Confidence 0.42 Published 2000 Journal Brain Res. Section Abstract Doc Link 11032994 Disease Relevance 0.14 Pain Relevance 1.33
The up-regulation of micro- and delta-opioid receptors was evident throughout the brain, although there was variation in the percentage change across brain regions.
Positive_regulation (up-regulation) of delta-opioid in brain associated with delta opioid receptors
17) Confidence 0.42 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12653976 Disease Relevance 0 Pain Relevance 0.61
In this paper we propose a powerful procedure to measure functional activation of the mouse delta-opioid receptor transiently expressed in mammalian cells.
Positive_regulation (activation) of delta-opioid receptor associated with opioid receptor
18) Confidence 0.42 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8947920 Disease Relevance 0 Pain Relevance 0.20
These results were confirmed by changes in the excitability of rotundal cells following electrical stimulation of the nBOR.
Positive_regulation (stimulation) of nBOR
19) Confidence 0.40 Published 2000 Journal Brain Behav. Evol. Section Abstract Doc Link 11251321 Disease Relevance 0 Pain Relevance 0.09
These results suggest (1) that delta opioid receptors can mediate analgesia and (2) that cerebroside sulfate is not necessary for delta opioid receptor activation.
Positive_regulation (activation) of delta opioid receptor associated with opioid receptor, delta opioid receptors and analgesia
20) Confidence 0.39 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3038573 Disease Relevance 0.08 Pain Relevance 1.12

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