INT78281

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2008
Negated 3
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 26.77
Pain Relevance 0.97

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Golgi apparatus (Krt7) structural molecule activity (Krt7) nucleus (Krt7)
cytoplasm (Krt7)
Anatomy Link Frequency
hepatocytes 3
Thyroid 1
4T1 1
lung 1
ducts 1
Krt7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 25 92.88 High High
endometriosis 7 91.56 High High
Bile 13 90.52 High High
Chronic pancreatitis 4 86.00 High High
metalloproteinase 3 83.60 Quite High
Pain 4 81.32 Quite High
fibrosis 33 76.16 Quite High
pain pelvic 1 59.36 Quite High
abdominal pain 1 38.76 Quite Low
Lasting pain 1 36.72 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 2 100.00 Very High Very High Very High
Pancreatic Cancer 21 99.98 Very High Very High Very High
Cancer 1006 99.84 Very High Very High Very High
Pseudomyxoma Peritonei 220 99.68 Very High Very High Very High
Adenocarcinoma 68 99.68 Very High Very High Very High
Disease 252 99.52 Very High Very High Very High
Ovarian Cancer 340 99.38 Very High Very High Very High
Targeted Disruption 64 98.40 Very High Very High Very High
Salivary Gland Disease 26 97.16 Very High Very High Very High
Endometroid Carcinoma 3 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As reflected by immunohistochemistry and western-blot analyses, although TOV-2223 tumor tissue expressed Krt7, the corresponding cell line seems to have lost the capacity to express this particular keratin (Figure 2E and 2I).
Gene_expression (expressed) of Krt7 associated with cancer
1) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.92 Pain Relevance 0
Both OSE and EOC tumors are characterized by the expression of different keratins such as KRT7, KRT8 and KRT18.
Gene_expression (expression) of KRT7 associated with cancer and ovarian cancer
2) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.80 Pain Relevance 0
Both TOV-1946 and OV-1946 cell lines expressed Krt7 and hence mirror keratin expression observed in vivo in the original tumor (Figure 2A and 2I).
Gene_expression (expressed) of Krt7 associated with cancer
3) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.84 Pain Relevance 0
It is also well described that monitoring expression of Krt7 and Krt20 could distinguish between ovarian and gastro-intestinal tract tumors (reviewed in [60]).
Gene_expression (expression) of Krt7 associated with cancer
4) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.69 Pain Relevance 0
In order to determine if our cell lines presented these EOC markers, we monitored protein expression of Krt7, Krt8 and Krt18 by western blot.
Gene_expression (expression) of Krt7 associated with ovarian cancer
5) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.78 Pain Relevance 0
Moreover, Krt7 is also differentially expressed between the TOV-1946 and OV-1946 cell lines that not only originate from the same type of disease but also from the same patient and differences are related to solid tumor versus ascites.
Gene_expression (expressed) of Krt7 associated with pressure and volume under development, solid tumor and disease
6) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 1.22 Pain Relevance 0
Stronger expression of Krt7 is observed in TOV-1946 and TOV-2223G was the only cell line that expressed Krt18 and Krt8.
Gene_expression (expression) of Krt7
7) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.97 Pain Relevance 0
Both TOV-1946 and OV-1946 cell lines expressed Krt7 and hence mirror keratin expression observed in vivo in the original tumor (Figure 2A and 2I).
Gene_expression (expression) of Krt7 associated with cancer
8) Confidence 0.55 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.85 Pain Relevance 0
The tumor cells of the lung were diffusely positive for cytokeratin 7, whereas cytokeratin 20 immunoreactivity was weak and focal, and that supported the lung origin of the present tumor.
Gene_expression (positive) of cytokeratin 7 in lung associated with cancer
9) Confidence 0.52 Published 1998 Journal Intern. Med. Section Abstract Doc Link 9804085 Disease Relevance 0.88 Pain Relevance 0.08
Adult hepatocytes contain K8 and K18 as their only cytoplasmic IF pair, whereas cholangiocytes express K7 and K19 in addition.
Gene_expression (express) of K7 in hepatocytes
10) Confidence 0.37 Published 2008 Journal Histochem Cell Biol Section Abstract Doc Link PMC2386529 Disease Relevance 0.87 Pain Relevance 0.04
For example, a low percentage of hepatocytes express keratin 7 and to a lesser extent keratin 19 which indicate that these cells acquire features of precursor cells which normally express keratin 8, 18, 7, and 19 during regeneration (Van Eyken et al. 1988; Zatloukal et al. 2004).
Gene_expression (express) of keratin 7 in hepatocytes
11) Confidence 0.37 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.61 Pain Relevance 0
Biliary epithelial cells differ from hepatocytes by additional expression of keratin 7 and 19 (Omary et al. 2002; Zatloukal et al. 2004).
Gene_expression (expression) of keratin 7 in hepatocytes
12) Confidence 0.32 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.31 Pain Relevance 0.05
For example, “simple” (i.e., single layered) epithelia, as found in digestive organs, express K8 together with variable levels of K7, K18, K19, and K20 depending on the tissue (Moll et al. 1982; Ku et al. 1999; Coulombe and Omary 2002; Ku et al. 2007).
Gene_expression (levels) of K7
13) Confidence 0.32 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.05 Pain Relevance 0
The tumor cells were immunopositive for cytokeratin 7, but negative for cytokeratin 20, and the tumor was histologically diagnosed as endometrioid adenocarcinoma of the mesocolon.
Neg (negative) Gene_expression (immunopositive) of cytokeratin 7 associated with endometroid carcinoma and cancer
14) Confidence 0.23 Published 2005 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 15741306 Disease Relevance 1.40 Pain Relevance 0.26
Besides ductal expression (double staining with CK 7, Fig.
Gene_expression (expression) of CK 7
15) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2329592 Disease Relevance 0.20 Pain Relevance 0
At early time-points, cells in the spheres expressed the distinctive submandibular gland duct cell type markers CK 7 (Fig. 2A, CK 7) and CK 14 (Fig. 2A, CK 14), revealing the ductal origin of the cells that initiated the sphere.
Gene_expression (expressed) of CK 7
16) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2329592 Disease Relevance 0 Pain Relevance 0
As expected, cytokeratin 7 was expressed in all PDAC cells and normal ducts (results not shown).


Gene_expression (expressed) of cytokeratin 7 in ducts associated with adenocarcinoma
17) Confidence 0.06 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 1.02 Pain Relevance 0
In immunohistochemical studies the tumor cells showed a strong expression of cytokeratin 7 and focal expression of cytokeratin 20 consistent with the diagnosis of gastric adenocarcinoma.
Gene_expression (expression) of cytokeratin 7 associated with adenocarcinoma and cancer
18) Confidence 0.04 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2275731 Disease Relevance 1.84 Pain Relevance 0
The expression of cytokeratin 7 is typical of ductal pancreatic carcinoma and its level is related to cancer differentiation.
Gene_expression (expression) of cytokeratin 7 associated with cancer and pancreatic cancer
19) Confidence 0.04 Published 2003 Journal Pol J Pathol Section Abstract Doc Link 12817878 Disease Relevance 1.34 Pain Relevance 0.09
All ductal pancreatic cancers expressed cytokeratin 7.
Gene_expression (expressed) of cytokeratin 7 associated with pancreatic cancer
20) Confidence 0.04 Published 2003 Journal Pol J Pathol Section Abstract Doc Link 12817878 Disease Relevance 1.62 Pain Relevance 0.12

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