INT78284

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Context Info
Confidence 0.49
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 40
Total Number 40
Disease Relevance 27.17
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTPRC)
Anatomy Link Frequency
bone marrow 3
fat 2
hematopoietic cells 2
mammary gland 1
SH2 1
PTPRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 13 98.36 Very High Very High Very High
Inflammation 197 98.30 Very High Very High Very High
cytokine 139 98.12 Very High Very High Very High
backache 2 96.24 Very High Very High Very High
abdominal pain 3 95.84 Very High Very High Very High
rheumatoid arthritis 82 91.20 High High
iatrogenic 9 90.28 High High
Central nervous system 6 88.64 High High
corticosteroid 15 88.24 High High
Pain 33 88.16 High High
Disease Link Frequency Relevance Heat
Ebola Virus Infection 55 99.98 Very High Very High Very High
Hyperglycemia 9 99.84 Very High Very High Very High
Cancer 217 99.78 Very High Very High Very High
Apoptosis 53 99.68 Very High Very High Very High
Muscle Disease 120 99.54 Very High Very High Very High
Prion Diseases 27 99.50 Very High Very High Very High
Endometriosis 12 99.48 Very High Very High Very High
Diabetic Macular Edema 9 98.84 Very High Very High Very High
Adhesions 26 98.78 Very High Very High Very High
Histiocytic Sarcoma 66 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The removal rate for menstrual side effects was highest for Cu T 380 A, 3x that of Cu T 200.
Positive_regulation (highest) of T 200
1) Confidence 0.49 Published 1979 Journal J Obstet Gynaecol India Section Abstract Doc Link 12335926 Disease Relevance 0.19 Pain Relevance 0.19
Immunohistochemical staining was positive for CD45 (LCA), CD56 (N-CAM), CD43 (MT1), and cytokeratin CAM5.2.
Positive_regulation (positive) of LCA
2) Confidence 0.49 Published 2001 Journal J. Histochem. Cytochem. Section Abstract Doc Link 11373326 Disease Relevance 0.47 Pain Relevance 0.09
In this gate, CECs were identified as positive for the specific marker CD146 (melanoma cell adhesion molecule (MCAM), a cell-adhesion molecule used as a marker for endothelial cell lineage) and negative for the hematopoietic marker CD45 (PTPRC, present on all differentiated hematopoietic cells; Figure 1).
Positive_regulation (negative) of PTPRC in hematopoietic cells associated with skin cancer and adhesions
3) Confidence 0.49 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.29 Pain Relevance 0
Consistent with other studies using a similar approach [49], preliminary experiments using the same conditioning regimen and transplanting CD45.1+ bone marrow into irradiated CD45.1?
Positive_regulation (irradiated) of CD45 in bone marrow
4) Confidence 0.49 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.35 Pain Relevance 0.03
In this gate, CECs were identified as positive for the specific marker CD146 (melanoma cell adhesion molecule (MCAM), a cell-adhesion molecule used as a marker for endothelial cell lineage) and negative for the hematopoietic marker CD45 (PTPRC, present on all differentiated hematopoietic cells; Figure 1).
Positive_regulation (negative) of CD45 in hematopoietic cells associated with skin cancer and adhesions
5) Confidence 0.49 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.29 Pain Relevance 0
His skin specimen revealed infiltration in the dermis and subcutaneous fat tissue by leukemic cells that were positive for the leukocyte common antigen (LCA, CD45), CD15, CD33, CD68, and HLA-DR.
Positive_regulation (positive) of LCA in fat
6) Confidence 0.45 Published 2001 Journal Leuk. Lymphoma Section Abstract Doc Link 11426568 Disease Relevance 0.76 Pain Relevance 0.08
They were negative for CD45 and CD20.
Positive_regulation (negative) of CD45
7) Confidence 0.39 Published 2001 Journal Am. J. Hematol. Section Abstract Doc Link 11426491 Disease Relevance 0.98 Pain Relevance 0.09
Endometriotic foci, however, contained elevated levels of CD45+, CD3+ and CD8+ cells and reduced numbers of CD56 + cells compared with the corresponding eutopic endometrium and these did not vary with menstrual cycle phase.
Positive_regulation (elevated) of CD45 in endometrium associated with endometriosis
8) Confidence 0.39 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9804254 Disease Relevance 0.86 Pain Relevance 0.62
Flow cytometry analysis revealed that the adherent fibroblast-like cells were consistently positive for CD29, CD44, CD105, and CD166, and were negative for CD14, CD34, and CD45.
Positive_regulation (negative) of CD45 in fibroblast
9) Confidence 0.36 Published 2007 Journal J. Cell. Physiol. Section Abstract Doc Link 17171634 Disease Relevance 0.62 Pain Relevance 0.07
In 25 control subjects, 65 patients with coronary artery disease (CAD; 40 stable CAD, 25 acute coronary syndrome/acute myocardial infarction (ACS)), EPC were quantified using the following approach: Whole blood was incubated with CD45, KDR, and CD34.
Positive_regulation (incubated) of CD45 in blood associated with acute coronary syndrome, coronary artery disease and myocardial infarction
10) Confidence 0.36 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2972200 Disease Relevance 0.86 Pain Relevance 0
primed BMMSCs only caused an increase in the CD45RO subset at 24 hr of activation suggesting induction of memory like phenotype (Figure 4D) It is possible that low levels of MSCs and priming could result in an initial activation response which is not sustained later on.
Positive_regulation (increase) of CD45RO
11) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.08 Pain Relevance 0.10
Immunohistochemical studies were positive for cytokeratin and vimentin; however, they were negative for CD45 and PAS.
Positive_regulation (negative) of CD45
12) Confidence 0.24 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2474610 Disease Relevance 1.09 Pain Relevance 0.11
Bone marrow derived cells were characterized for the presence of mesenchymal markers (CD73, CD44, CD90, CD105) and absence of CD34 and CD45 before performing different experiments (Figure S1A).
Positive_regulation (absence) of CD45 in Bone marrow
13) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0 Pain Relevance 0
Immunohistochemical staining in the tumor cells was positive for CD163, CD68, lysozyme, CD45, and NSE.
Positive_regulation (positive) of CD45 associated with cancer
14) Confidence 0.19 Published 2007 Journal Diagn Pathol Section Abstract Doc Link PMC1808440 Disease Relevance 0.86 Pain Relevance 0
T cell surface molecules, some of them upregulated on activation, such as CD69 [2,3], CD23 [4,5], integrins [6], CD40-CD40 ligand [7], LAG-3 [8], CD45 [9], LFA-1 and ICAM-1 [10] and membrane-bound cytokines [11] have all been implicated in this activation.
Positive_regulation (upregulated) of CD45 in T cell associated with cytokine
15) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 1.08 Pain Relevance 0.42
His skin specimen revealed infiltration in the dermis and subcutaneous fat tissue by leukemic cells that were positive for the leukocyte common antigen (LCA, CD45), CD15, CD33, CD68, and HLA-DR.
Positive_regulation (positive) of CD45 in fat
16) Confidence 0.13 Published 2001 Journal Leuk. Lymphoma Section Abstract Doc Link 11426568 Disease Relevance 0.76 Pain Relevance 0.08
Immunohistochemistry is variable, but in most cases, staining is positive for CD68, CD4, CD45, HLA-DR, and lysozyme, but negative for S100, CD20, and factor XIIIa [7].
Positive_regulation (positive) of CD45
17) Confidence 0.10 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770547 Disease Relevance 1.05 Pain Relevance 0.10
The latter consistently expresses S-100 protein, ATPase and HLA-DR, and is variably, weakly positive for CD68, lysozyme, and CD45 [1,5-8].
Positive_regulation (positive) of CD45
18) Confidence 0.07 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.10 Pain Relevance 0
This glycoprotein is further processed to fibrillin-1, the main component of 10–12 nm extracellular microfibrils that are widely distributed in both elastic and non-elastic tissues including the skin, aorta, periosteum, cartilage, and ciliary zonules [5-8].
Positive_regulation (processed) of glycoprotein in periosteum
19) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2443751 Disease Relevance 0.65 Pain Relevance 0
As in the case of the aforementioned membrane-bound glycoprotein, NEP activity decreased significantly in CCRCC (fourfold), ChRCC (fivefold) and RO (sevenfold) when compared with the normal tissue samples.
Positive_regulation (aforementioned) of glycoprotein
20) Confidence 0.06 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.63 Pain Relevance 0

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