INT7829

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Context Info
Confidence 0.30
First Reported 1992
Last Reported 1998
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.41
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprd1) plasma membrane (Oprd1) cytoplasm (Oprd1)
signal transducer activity (Oprd1)
Anatomy Link Frequency
brain 2
Oprd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 7 100.00 Very High Very High Very High
Analgesic 3 100.00 Very High Very High Very High
Delta opioid receptors 3 100.00 Very High Very High Very High
antinociception 6 99.38 Very High Very High Very High
Opioid 5 99.06 Very High Very High Very High
Cholecystokinin 8 98.88 Very High Very High Very High
agonist 4 97.52 Very High Very High Very High
Spinal cord 1 94.68 High High
tail-flick 1 80.60 Quite High
opioid receptor 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 4 95.28 Very High Very High Very High
Urological Neuroanatomy 1 94.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present data demonstrate a deficiency in delta1 and delta2 opioid antinociception in CXBK mice concomitant with reductions in whole-brain delta2 receptor binding and regional increases in DOR-1.
Negative_regulation (reductions) of Positive_regulation (increases) of DOR-1 in brain associated with antinociception and opioid
1) Confidence 0.30 Published 1998 Journal Brain Res. Section Abstract Doc Link 9733948 Disease Relevance 0.41 Pain Relevance 1.03
Stimulation of delta-opioid receptors reduces the in vivo binding of the cholecystokinin (CCK)-B-selective agonist [3H]pBC 264: evidence for a physiological regulation of CCKergic systems by endogenous enkephalins.
Negative_regulation (reduces) of Positive_regulation (Stimulation) of delta-opioid associated with analgesic, agonist, enkephalin, delta opioid receptors and cholecystokinin
2) Confidence 0.03 Published 1992 Journal J. Neurochem. Section Title Doc Link 1357099 Disease Relevance 0 Pain Relevance 0.92

General Comments

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