INT78297

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Context Info
Confidence 0.72
First Reported 1998
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 31
Total Number 37
Disease Relevance 24.11
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD59) plasma membrane (CD59)
Anatomy Link Frequency
urine 6
erythrocytes 5
granulocytes 2
eye 2
monocytes 2
CD59 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 2 99.42 Very High Very High Very High
Inflammation 111 98.56 Very High Very High Very High
antagonist 5 98.26 Very High Very High Very High
Dopamine 179 97.52 Very High Very High Very High
cytokine 13 95.52 Very High Very High Very High
psoriasis 3 92.36 High High
rheumatoid arthritis 7 91.92 High High
cINOD 11 90.08 High High
abdominal pain 17 88.88 High High
imagery 17 83.00 Quite High
Disease Link Frequency Relevance Heat
Paroxysmal Nocturnal Hemoglobinuria 892 99.84 Very High Very High Very High
Lifespan 6 99.64 Very High Very High Very High
Hemolysis 287 99.34 Very High Very High Very High
Cancer 145 99.32 Very High Very High Very High
Obesity 23 99.24 Very High Very High Very High
Ovarian Cancer 203 98.84 Very High Very High Very High
Adenocarcinoma 7 98.80 Very High Very High Very High
INFLAMMATION 132 98.56 Very High Very High Very High
Communicable Diseases 3 97.98 Very High Very High Very High
Disease 295 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like CD59, kininogen-1 is also detectable in the urine of healthy individuals.
Gene_expression (detectable) of CD59 in urine
1) Confidence 0.72 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.86 Pain Relevance 0
Further confirmation of the altered levels of CD59, kininogen-1 and fragments of ITIH4 and albumin in the urine of patients with ovarian carcinoma relative to those of the control subjects was performed using antibodies and a lectin that bind to the respective proteins that were blotted onto membranes.
Gene_expression (levels) of CD59 in urine associated with ovarian cancer
2) Confidence 0.72 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.46 Pain Relevance 0
To generate pminiTol2/SVneo (pDB678), the same fragment was cloned between HindIII and SwaI sites of pGEM-T/Tol2.
Gene_expression (generate) of mini
3) Confidence 0.65 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1635535 Disease Relevance 0.21 Pain Relevance 0
The efficiency of miniTol2/SVneo was set as 100%.


Gene_expression (efficiency) of mini
4) Confidence 0.65 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1635535 Disease Relevance 0 Pain Relevance 0
It is observed that, in both cases, the Max-Min parameters were independent of Gain, Time Gain Compensation (TGC), tissue attenuation and size of region of interest (ROI).


Neg (independent) Gene_expression (independent) of Min
5) Confidence 0.65 Published 2009 Journal The Open Medical Informatics Journal Section Body Doc Link PMC2705135 Disease Relevance 0 Pain Relevance 0
GST fusion proteins and mini-gene
Gene_expression (proteins) of mini
6) Confidence 0.65 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.10
The 22-kb mini human TDP gene was extracted from a BAC clone (RP11-829B14), and a M337V substitution was introduced into the mini TDP gene by homologous recombination in Escherichia coli [22].
Gene_expression (introduced) of mini
7) Confidence 0.65 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2845661 Disease Relevance 0.71 Pain Relevance 0
The reason for the low levels of CD59 in the urine of cancer patients is not understood.
Gene_expression (levels) of CD59 in urine associated with cancer
8) Confidence 0.62 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.83 Pain Relevance 0
A flow cytometry evaluation of CD55 and/or CD59, CD59, and CD48 expression in erythrocytes, granulocytes, and monocytes, respectively, showed that the respective proportions of negative populations were 5.6%, 97.1%, and 96.2%.
Gene_expression (expression) of CD59 in monocytes
9) Confidence 0.59 Published 2007 Journal Int. J. Hematol. Section Abstract Doc Link 17988986 Disease Relevance 1.71 Pain Relevance 0.09
A flow cytometry evaluation of CD55 and/or CD59, CD59, and CD48 expression in erythrocytes, granulocytes, and monocytes, respectively, showed that the respective proportions of negative populations were 5.6%, 97.1%, and 96.2%.
Gene_expression (expression) of CD59 in monocytes
10) Confidence 0.59 Published 2007 Journal Int. J. Hematol. Section Abstract Doc Link 17988986 Disease Relevance 1.71 Pain Relevance 0.09
CD55 (decay accelerating factor, DAF) and CD59 (membrane inhibitor of reactive lysis, MIRL) are widely expressed on all hemopoietic cells and are both involved in the regulation of complement activation.
Gene_expression (expressed) of MIRL in hemopoietic cells
11) Confidence 0.58 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789686 Disease Relevance 0.42 Pain Relevance 0
Moreover, coexpression of an interfering DAT-CT minigene inhibited the effects of CPE on DAT.
Gene_expression (coexpression) of mini
12) Confidence 0.58 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.16
When taken as overall, the levels of CD59, kininogen-1 and ITIH4 fragment were significantly lower in ovarian carcinoma patients by 3.6-, 2.5- and 1.9-folds, respectively, compared to those excreted by the control subjects.
Gene_expression (levels) of CD59 associated with ovarian cancer
13) Confidence 0.56 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.43 Pain Relevance 0
Significant reduced levels of CD59, kininogen-1 and a 39 kDa fragment of inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4), and enhanced excretion of a 19 kDa fragment of albumin, were detected in the urine of patients with ovarian carcinoma compared to the control subjects.
Gene_expression (levels) of CD59 in urine associated with ovarian cancer
14) Confidence 0.56 Published 2010 Journal Proteome Sci Section Abstract Doc Link PMC2998473 Disease Relevance 0.52 Pain Relevance 0
The different altered levels of CD59, kininogen-1 and fragments of ITIH4 and albumin in the urine of patients with ovarian carcinoma, relative to the controls, was confirmed when their 2-DE urine protein profiles were subjected to image analysis using the Image Master 2 D Platinum Software 7.0.
Gene_expression (levels) of CD59 in urine associated with ovarian cancer
15) Confidence 0.56 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.22 Pain Relevance 0
The proteomic profiling of urine samples demonstrated reduced levels of CD59, kininogen-1 and a 39 kDa ITIH4 fragment, as well as the enhanced excretion of a 19 kDa fragment of albumin in patients with ovarian carcinoma compared to control women.
Gene_expression (levels) of CD59 in urine associated with ovarian cancer
16) Confidence 0.56 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.46 Pain Relevance 0
We reported that membrane-bound CRegs—MCP, DAF, and CD59—are differentially expressed in normal human and eyes [33].
Gene_expression (expressed) of CD59 in eyes
17) Confidence 0.47 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.06 Pain Relevance 0.03
Our studies along with other independent studies that were performed later demonstrated that Crry and CD59 (membrane bound and soluble) are also present in the normal rodent eye [32, 34, 35].
Gene_expression (present) of CD59 in eye
18) Confidence 0.47 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.07 Pain Relevance 0.04
Membrane-bound CRegs such as MCP, DAF, Crry (Fig. 2a), and CD59 (Fig. 2b) are expressed in the different layers of the cornea to protect this tissue from complement-mediated damage [27, 33, 50].
Gene_expression (expressed) of CD59 in cornea
19) Confidence 0.47 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.58 Pain Relevance 0.05
Adipose tissue-derived stem cells are understood to express surface markers of CD9, CD10, CD13, CD29, CD44, CD49d, CD49e, CD54, CD55, CD59, CD73, CD90, CD105, CD146, CD166, and STRO-1, and lack hematopoietic lineage markers CD11b, CD14, CD19, CD34, and CD45 [20,34,50-53].
Neg (lack) Gene_expression (express) of CD59 in stem cells associated with obesity
20) Confidence 0.43 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0.17 Pain Relevance 0.06

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