INT78316

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Context Info
Confidence 0.16
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.09
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (TGM6) transferase activity, transferring acyl groups (TGM6)
Anatomy Link Frequency
brain 1
TGM6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 5 100.00 Very High Very High Very High
Gabapentin 5 99.92 Very High Very High Very High
Calcium channel 4 99.60 Very High Very High Very High
pregabalin 5 99.32 Very High Very High Very High
Multiple sclerosis 1 89.84 High High
Hippocampus 1 79.48 Quite High
Disease Link Frequency Relevance Heat
Ataxia 10 100.00 Very High Very High Very High
Spinocerebellar Ataxia Type 2 9 100.00 Very High Very High Very High
Migraine With Aura 5 100.00 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 8 99.04 Very High Very High Very High
Congenital Anomalies 1 92.48 High High
Metabolic Disorder 1 91.48 High High
Increased Venous Pressure Under Development 1 90.64 High High
Demyelinating Disease 1 89.84 High High
Disease 3 87.40 High High
Vertigo 1 79.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EA-2 has been associated with mutations in the alpha 1A-voltage dependent calcium channel gene (CACNL1A4), which is also affected in familial hemiplegic migraine (FMH) and spinocerebellar ataxia type 6 (SCA6).
Regulation (affected) of spinocerebellar ataxia type 6 associated with migraine with aura, migraine, calcium channel, spinocerebellar ataxia type 2 and ocular toxicity (including many sub-types)
1) Confidence 0.16 Published 1998 Journal Rinsho Shinkeigaku Section Abstract Doc Link 9805992 Disease Relevance 2.12 Pain Relevance 0.19
BACKGROUND: Different mutations in the alpha 1A-subunit of the brain P/Q-type calcium channel gene (CACNA1A) are responsible for familial hemiplegic migraine (FHM), episodic ataxia type 2, and spinocerebellar ataxia type 6 (SCA6).
Regulation (responsible) of spinocerebellar ataxia type 6 in brain associated with ataxia, migraine with aura, migraine, calcium channel and spinocerebellar ataxia type 2
2) Confidence 0.01 Published 2003 Journal Arch. Neurol. Section Abstract Doc Link 12707077 Disease Relevance 0.65 Pain Relevance 0.42
The P/Q-type voltage-dependent calcium channel as pharmacological target in spinocerebellar ataxia type 6: gabapentin and pregabalin may be of therapeutic benefit.
Regulation (target) of spinocerebellar ataxia type 6 associated with pregabalin, calcium channel, spinocerebellar ataxia type 2 and gabapentin
3) Confidence 0.01 Published 2007 Journal Med. Hypotheses Section Title Doc Link 16899342 Disease Relevance 0.32 Pain Relevance 0.34

General Comments

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