INT78317

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Context Info
Confidence 0.62
First Reported 1998
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 7.68
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CACNA1A) cell death (CACNA1A) plasma membrane (CACNA1A)
nucleus (CACNA1A) transmembrane transport (CACNA1A) cytoplasm (CACNA1A)
Anatomy Link Frequency
cerebellum 1
CACNA1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 96 100.00 Very High Very High Very High
Calcium channel 45 100.00 Very High Very High Very High
Serotonin 5 99.40 Very High Very High Very High
Cluster headache 7 99.24 Very High Very High Very High
Neurotransmitter 17 98.88 Very High Very High Very High
Neuropeptide 3 95.32 Very High Very High Very High
Multiple sclerosis 3 90.84 High High
gABA 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Migraine With Aura 56 100.00 Very High Very High Very High
Spinocerebellar Ataxia Type 2 7 100.00 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 16 99.52 Very High Very High Very High
Cerebellar Diseases 5 99.32 Very High Very High Very High
Cluster Headache 7 99.24 Very High Very High Very High
Migraine Disorders 46 98.80 Very High Very High Very High
Headache 13 98.08 Very High Very High Very High
Ataxia 19 97.84 Very High Very High Very High
Epilepsy 3 97.48 Very High Very High Very High
Congenital Anomalies 4 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EA-2 has been associated with mutations in the alpha 1A-voltage dependent calcium channel gene (CACNL1A4), which is also affected in familial hemiplegic migraine (FMH) and spinocerebellar ataxia type 6 (SCA6).
Regulation (affected) of SCA6 associated with migraine with aura, migraine, calcium channel, spinocerebellar ataxia type 2 and ocular toxicity (including many sub-types)
1) Confidence 0.62 Published 1998 Journal Rinsho Shinkeigaku Section Abstract Doc Link 9805992 Disease Relevance 2.12 Pain Relevance 0.19
EA-2 has been associated with mutations in the alpha 1A-voltage dependent calcium channel gene (CACNL1A4), which is also affected in familial hemiplegic migraine (FMH) and spinocerebellar ataxia type 6 (SCA6).
Regulation (affected) of CACNL1A4 associated with migraine with aura, migraine, calcium channel, spinocerebellar ataxia type 2 and ocular toxicity (including many sub-types)
2) Confidence 0.62 Published 1998 Journal Rinsho Shinkeigaku Section Abstract Doc Link 9805992 Disease Relevance 2.12 Pain Relevance 0.19
We find that CACNA1A is regulated by a combination of binding sites of various affinities and degrees of phylogenetic conservation.
Regulation (regulated) of CACNA1A
3) Confidence 0.51 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0.30 Pain Relevance 0.16
The findings in this invertebrate model constitute the first direct demonstration of how CACNA1A function might affect the levels of serotonin, a neurotransmitter known to be important in migraine.
Spec (might) Regulation (affect) of CACNA1A associated with neurotransmitter, migraine and serotonin
4) Confidence 0.43 Published 2006 Journal Headache Section Abstract Doc Link 16927961 Disease Relevance 0.53 Pain Relevance 0.59
REST regulation of CACNA1A through multiple binding sites
Regulation (regulation) of CACNA1A
5) Confidence 0.38 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0.06 Pain Relevance 0
The CACNA1A gene encoding Cav2.1 is highly expressed in the Purkinje cells of the cerebellum (32) and mutations in CACNA1A are responsible for a number of cerebellar disorders including migraine (33), epilepsy (34) and ataxias (35) but little is known about the transcriptional regulation of this gene.
Regulation (responsible) of CACNA1A in cerebellum associated with epilepsy, cerebellar diseases, ataxia and migraine
6) Confidence 0.38 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0.39 Pain Relevance 0.31
The two new regions can open the way for the study of human CACNA1A gene expression regulation and can be sites of mutations associated with FHM or EA phenotypes.
Regulation (regulation) of CACNA1A associated with ataxia and migraine
7) Confidence 0.27 Published 2009 Journal J. Neurol. Sci. Section Abstract Doc Link 18976783 Disease Relevance 0.66 Pain Relevance 0.32
No involvement of the calcium channel gene (CACNA1A) in a family with cluster headache.
Neg (No) Regulation (involvement) of CACNA1A associated with cluster headache and calcium channel
8) Confidence 0.26 Published 2001 Journal Cephalalgia Section Title Doc Link 11843867 Disease Relevance 1.00 Pain Relevance 0.95
These results do not show a significant role for the tested candidate gene variants and also do not support the hypothesis that a common chromosome 1 defective gene influences both FHM and the more common forms of migraine.



Regulation (influences) of FHM associated with migraine
9) Confidence 0.20 Published 2007 Journal BMC Med Genet Section Abstract Doc Link PMC2034370 Disease Relevance 0.51 Pain Relevance 0.35

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