INT78319

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Context Info
Confidence 0.36
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 10.12
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EPCAM)
Anatomy Link Frequency
blood 1
brain 1
platelet 1
T cell 1
EPCAM (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 18 98.54 Very High Very High Very High
palliative 46 97.60 Very High Very High Very High
depression 4 94.12 High High
Arthritis 1 92.16 High High
headache 6 84.56 Quite High
cytokine 15 82.92 Quite High
Pain 8 75.68 Quite High
fibrosis 8 59.56 Quite High
abdominal pain 5 25.00 Low Low
Inflammation 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 251 100.00 Very High Very High Very High
Kaposis Sarcoma 146 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 112 100.00 Very High Very High Very High
Adhesions 10 100.00 Very High Very High Very High
Adenocarcinoma 1 100.00 Very High Very High Very High
Lymphedema 76 99.98 Very High Very High Very High
Breast Cancer 9 99.92 Very High Very High Very High
Brain Tumor 1 99.20 Very High Very High Very High
Cv General 3 Under Development 12 98.54 Very High Very High Very High
Prostate Cancer 1 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It recognises the human tumour-associated antigen CO17-1A which is expressed on the cell surface of a wide variety of tumours and normal epithelial tissue.
CO17-1A Binding (recognises) of associated with cancer
1) Confidence 0.36 Published 1998 Journal Drugs Section Abstract Doc Link 9806108 Disease Relevance 0.39 Pain Relevance 0
Trifunctional antibodies have a much higher capacity for tumor kill than previous monoclonal antibody lines.57 Preclinical models have shown that the improved effectiveness of these antibodies lies in the ability of the fragment crystallizable (Fc) and fragment antigen-binding (Fab) portions of the antibody to trigger an immune response by interacting with EpCAM and the cluster of differentiation (CD) 3.
EpCAM Binding (interacting) of associated with cancer
2) Confidence 0.26 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880345 Disease Relevance 1.01 Pain Relevance 0.07
Catumaxomab, a trifunctional bispecific monoclonal antibody, has two binding specificities directed to epithelial cell adhesion molecule (EpCAM) and the T cell antigen CD3.
EpCAM Binding (binding) of in T cell associated with adhesions
3) Confidence 0.21 Published 2010 Journal Cancer management and research Section Abstract Doc Link PMC3004584 Disease Relevance 0.75 Pain Relevance 0
ESA use was associated with a mean difference of 1.05 units of blood transfused.
ESA Binding (associated) of in blood
4) Confidence 0.08 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 0.32 Pain Relevance 0
The safety profile of ESAs remains a highly contentious issue.44,45 In the presence of accumulating data indicating potential harm, regulatory authorities have increasingly restricted approved indications for ESA use.
ESA Binding (indications) of
5) Confidence 0.08 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 0.70 Pain Relevance 0.24
At present both ASCO/ASH and ESMO guidelines recommend that each patientÂ’s baseline thromboembolic risk is taken into account when considering the risk: benefit ratio for commencing ESA therapy.25,26 Whether anti-platelet or anticoagulant therapy may have a role in modulating the risk of TEE is unknown.52

Overall survival/tumor progression

ESA Spec (Whether) Binding (commencing) of in platelet associated with cancer and cva
6) Confidence 0.08 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 0.41 Pain Relevance 0.05
Numerous terms relating to cancer were also revealed, for example: adenocarcinoma; breast neoplasms; brain neoplasms; prostatic neoplasms; and neoplasms.
adenocarcinoma Binding (example) of in brain associated with adenocarcinoma, cancer, breast cancer, prostate cancer and brain tumor
7) Confidence 0.04 Published 2007 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC1931586 Disease Relevance 1.50 Pain Relevance 0.68
Lymphoedema associated with HIV-KS
HIV-KS Binding (associated) of associated with kaposis sarcoma, acquired immune deficiency syndrome or hiv infection and lymphedema
8) Confidence 0.01 Published 2008 Journal AIDS Res Ther Section Body Doc Link PMC2275292 Disease Relevance 2.02 Pain Relevance 0.10
Treatment of lymphoedema associated with HIV-KS focuses on treatment of both the HIV-KS and the lymphoedema.
HIV-KS Binding (associated) of associated with kaposis sarcoma, acquired immune deficiency syndrome or hiv infection and lymphedema
9) Confidence 0.01 Published 2008 Journal AIDS Res Ther Section Body Doc Link PMC2275292 Disease Relevance 3.02 Pain Relevance 0

General Comments

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