INT78320

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 57
Total Number 62
Disease Relevance 50.34
Pain Relevance 7.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EPCAM)
Anatomy Link Frequency
lung 3
epithelial cell 3
peritoneum 2
pleura 2
bladder 2
EPCAM (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 30 99.80 Very High Very High Very High
Analgesic 80 99.60 Very High Very High Very High
Dynorphin 12 99.48 Very High Very High Very High
palliative 29 98.74 Very High Very High Very High
Pain 183 98.28 Very High Very High Very High
Hyperalgesia 25 98.12 Very High Very High Very High
Inflammation 124 97.60 Very High Very High Very High
Enkephalin 12 97.16 Very High Very High Very High
Central nervous system 13 95.68 Very High Very High Very High
Endogenous opioid 18 95.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1855 100.00 Very High Very High Very High
Adhesions 49 100.00 Very High Very High Very High
Mesothelioma 282 99.98 Very High Very High Very High
Carcinoma 199 99.84 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 48 99.84 Very High Very High Very High
Solid Tumor 59 99.64 Very High Very High Very High
Transitional Cell Carcinoma 56 99.64 Very High Very High Very High
Anaemia 903 99.60 Very High Very High Very High
Adenocarcinoma 34 99.40 Very High Very High Very High
Disease 422 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It recognises the human tumour-associated antigen CO17-1A which is expressed on the cell surface of a wide variety of tumours and normal epithelial tissue.
Gene_expression (expressed) of CO17-1A associated with cancer
1) Confidence 0.75 Published 1998 Journal Drugs Section Abstract Doc Link 9806108 Disease Relevance 0.39 Pain Relevance 0
Cellular subsets sorted according to expression of CD24a, CD49f, CD61, Epcam, Sca1, and Thy1 cell surface proteins, or metabolic markers (e.g.
Gene_expression (expression) of Epcam
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920333 Disease Relevance 0.64 Pain Relevance 0
After 3 days in culture, 8.9% of the eGFP-positive cells revealed strong expression of Epcam (Figure 11C, right), while the fraction of Epcam-expressing eGFP-positive cells increased ?
Gene_expression (expressing) of Epcam
3) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.07 Pain Relevance 0
Using the five-marker gene-panel (mam, PIP, CEA, PSE and EpCAM) at the threshold of three standard deviations above the mean expression level in normal control samples for each gene, 136 (63%) patients out of 215 were positive for at least one marker.
Gene_expression (expression) of EpCAM
4) Confidence 0.62 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.47 Pain Relevance 0
The outstanding diagnostic feature of HAC is positivity for alphafetoprotein (AFP) (88%), HepPar1 (63%), and EpCAM antibodies HEA125 or MOC31 which show no reactivity with hepatocytes.
Gene_expression (antibodies) of EpCAM in hepatocytes associated with adenocarcinoma
5) Confidence 0.57 Published 2010 Journal Onkologie Section Abstract Doc Link 20502062 Disease Relevance 1.21 Pain Relevance 0.09
For this study we selected seven breast cancer-associated genes [mam, CEA, CK19, PIP, muc1, PSE, Erb (BM only) and EpCAM (PBL only)] known to be over-expressed in metastatic breast cancer compared to control lymph nodes [31,36,37].
Gene_expression (expressed) of EpCAM in lymph nodes associated with breast cancer and advanced or metastatic breast cancer
6) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.66 Pain Relevance 0
Some studies have also used a new CellSearch System technology that employs immunomagnetic separation of epithelial cells based upon expression of cytokeratins or EpCAM and visualization of the tumor cells by immunoflorescent microscopy [30].
Gene_expression (expression) of EpCAM in epithelial cells associated with cancer
7) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 1.04 Pain Relevance 0
The genes like CK19, muc1, PSE and EpCAM that show significant background expression in normal samples, loose its accuracy in tumor cell detection when Ficoll density gradient cell separation methodology is used.
Gene_expression (expression) of EpCAM associated with cancer
8) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.62 Pain Relevance 0
However, the system is restricted to the enrichment of epithelial cell adhesion molecule (EpCAM) positive CTCs and EpCAM expression can be lost or downregulated as a consequence of an epithelial to mesenchymal transition [30,31].
Gene_expression (expression) of EpCAM in epithelial cell associated with adhesions
9) Confidence 0.51 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2605098 Disease Relevance 0.50 Pain Relevance 0
One cellular adhesion protein called epithelial cell adhesion molecule (EpCAM) is a 40 kDa cell surface glycoprotein that mediates epithelium-specific, homotypic cell to cell adhesion on normal cells.55,56 EpCAM is a significant tumor antigen because its overexpression has been observed in a majority of carcinomas including ovarian cancer, breast cancer, prostate cancer, and nonsmall cell lung cancer.56 The inhibition of this antigen has been associated with a decrease in the proliferation, migration, and invasion of cancer cells, therefore making it an important target for cancer immunotherapy.


Gene_expression (overexpression) of EpCAM in lung associated with non-small-cell lung cancer, cancer, ovarian cancer, carcinoma, immunotherapy of cancer, reprotox - general 1 and adhesions
10) Confidence 0.48 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880345 Disease Relevance 2.89 Pain Relevance 0.06
One cellular adhesion protein called epithelial cell adhesion molecule (EpCAM) is a 40 kDa cell surface glycoprotein that mediates epithelium-specific, homotypic cell to cell adhesion on normal cells.55,56 EpCAM is a significant tumor antigen because its overexpression has been observed in a majority of carcinomas including ovarian cancer, breast cancer, prostate cancer, and nonsmall cell lung cancer.56 The inhibition of this antigen has been associated with a decrease in the proliferation, migration, and invasion of cancer cells, therefore making it an important target for cancer immunotherapy.


Gene_expression (overexpression) of EpCAM in lung associated with non-small-cell lung cancer, cancer, ovarian cancer, carcinoma, immunotherapy of cancer, reprotox - general 1 and adhesions
11) Confidence 0.48 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880345 Disease Relevance 2.56 Pain Relevance 0
Results were negative for carcinoembrionary antigen and the epithelial glycoprotein Ber-EP4, whereas results were positive for the mesothelial markers cytokeratins, calretinin, epithelial membrane antigen, and HBME-1, thus leading to the correct diagnosis of peritoneal epithelial mesothelioma.
Neg (negative) Gene_expression (negative) of epithelial glycoprotein Ber-EP4 associated with lung cancer
12) Confidence 0.46 Published 2004 Journal Environ Health Perspect Section Abstract Doc Link PMC1241930 Disease Relevance 0.67 Pain Relevance 0.06
However, the system is restricted to the enrichment of epithelial cell adhesion molecule (EpCAM) positive CTCs and EpCAM expression can be lost or downregulated as a consequence of an epithelial to mesenchymal transition [30,31].
Gene_expression (expression) of EpCAM in epithelial cell associated with adhesions
13) Confidence 0.45 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2605098 Disease Relevance 0.50 Pain Relevance 0
The effect produced by 2 Hz ESA was naloxone-reversible, while high frequency stimulation was not (6).
Gene_expression (produced) of ESA associated with narcan
14) Confidence 0.42 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693606 Disease Relevance 0.69 Pain Relevance 1.30
Previous studies have revealed that ESA with low (2-10 Hz) and high (?
Gene_expression (revealed) of ESA
15) Confidence 0.42 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693606 Disease Relevance 0.51 Pain Relevance 0.49
These inconsistent results reflect that ESA of specific frequencies may produce different effects to the several types of pain and hyperalgesia.
Gene_expression (produce) of ESA associated with pain and hyperalgesia
16) Confidence 0.42 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693606 Disease Relevance 1.80 Pain Relevance 1.57
Another study has reported that low frequency ESA produced superior analgesic effects in response to noxious radiant heat stimuli (10).
Gene_expression (produced) of ESA in superior associated with analgesic
17) Confidence 0.42 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693606 Disease Relevance 1.42 Pain Relevance 1.41
Based on these findings, ESA with low and high frequencies seems to produce the different therapeutic effect.
Gene_expression (produce) of ESA
18) Confidence 0.42 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693606 Disease Relevance 0.87 Pain Relevance 0.62
Only 2 Hz ESA produced the significant rapid decrease in ankle edema.
Gene_expression (produced) of ESA in ankle associated with pressure and volume under development
19) Confidence 0.42 Published 2007 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2693606 Disease Relevance 1.02 Pain Relevance 0.37
Based on these criteria, the following candidate markers with available serum assays were selected for testing: WFDC2, MSLN, IGF2, CHI3L1, MMP7, BMP7, LCN2, TACSTD1.
Gene_expression (selected) of TACSTD1
20) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440813 Disease Relevance 0.69 Pain Relevance 0

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