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Context Info
Confidence 0.47
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.74
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCK) extracellular space (CCK) extracellular region (CCK)
Anatomy Link Frequency
visceral 2
plasma 2
CCK (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 33 100.00 Very High Very High Very High
Somatostatin 2 100.00 Very High Very High Very High
agonist 3 99.56 Very High Very High Very High
Chronic pancreatitis 3 98.64 Very High Very High Very High
Pain 8 97.40 Very High Very High Very High
Morphine 7 94.88 High High
spastic colon 64 94.44 High High
Analgesic 3 94.04 High High
analgesia 2 87.84 High High
nud 5 85.44 High High
Disease Link Frequency Relevance Heat
Pancreatitis 3 98.64 Very High Very High Very High
Pain 8 97.40 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

64 94.44 High High
Dyspepsia 5 85.44 High High
Intractable Pain 1 81.60 Quite High
Disease 2 52.80 Quite High
Gallstones 1 52.48 Quite High
Panic Disorder 1 51.96 Quite High
Alcohol Addiction 1 51.24 Quite High
Schizophrenia 1 50.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the possible factors contributing to this limitation are increased levels of cholecystokinin (CCK).
Positive_regulation (increased) of Positive_regulation (levels) of CCK associated with cholecystokinin
1) Confidence 0.47 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9806692 Disease Relevance 0.25 Pain Relevance 1.11
This suggested that, compared to the 779 T variant, the 779 C substitution resulted in an increased response to endogenous CCK (like CCK agonist), which was followed by delaying gastric emptying.7 From the viewpoint of sensory functions at various levels of the gastrointestinal tract, our results are consistent with the original hypothesis that suggested that the CCK1 receptor intron 1 779 T > C polymorphic type might have an increased response to endogenous CCK and be associated with visceral hypersensitivity.
Positive_regulation (increased) of Positive_regulation (response) of CCK in visceral associated with agonist, nud and cholecystokinin
2) Confidence 0.46 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2879831 Disease Relevance 0.40 Pain Relevance 1.09
The presence of such a feedback mechanism in chronic pancreatitis patients with exocrine enzyme deficiency possibly leads to an increase in cholecystokinin plasma levels.
Positive_regulation (leads) of Positive_regulation (increase) of cholecystokinin in plasma associated with somatostatin, cholecystokinin and chronic pancreatitis
3) Confidence 0.46 Published 2000 Journal Hepatogastroenterology Section Abstract Doc Link 10919050 Disease Relevance 0.36 Pain Relevance 0.63

General Comments

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