INT78328

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.84
Pain Relevance 4.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCK) extracellular space (CCK) extracellular region (CCK)
Anatomy Link Frequency
endocrine cells 2
CCK (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 75 100.00 Very High Very High Very High
Chronic pancreatitis 57 99.10 Very High Very High Very High
Pain 32 97.40 Very High Very High Very High
Morphine 14 94.88 High High
Analgesic 7 94.04 High High
agonist 2 88.80 High High
analgesia 5 87.84 High High
nud 2 81.64 Quite High
Intractable pain 2 81.60 Quite High
Inflammation 7 80.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 4 99.92 Very High Very High Very High
Critical Illness 53 99.50 Very High Very High Very High
Pancreatitis 57 99.10 Very High Very High Very High
Adenocarcinoma 6 98.72 Very High Very High Very High
Pain 29 97.40 Very High Very High Very High
Aggression 1 92.80 High High
Body Weight 8 91.04 High High
Dyspepsia 2 81.64 Quite High
Intractable Pain 2 81.60 Quite High
INFLAMMATION 7 80.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased and ectopic gastrin/CCK expression was correlated with pancreatic adenocarcinomas exhibiting poor histological grade and neoplastic endocrine cells, providing a potential marker for pancreatic adenocarcinomas with aggressive behavior.
Positive_regulation (Increased) of Gene_expression (expression) of CCK in endocrine cells associated with adenocarcinoma, aggression and cholecystokinin
1) Confidence 0.70 Published 2007 Journal Ultrastruct Pathol Section Abstract Doc Link 17786831 Disease Relevance 1.23 Pain Relevance 0.24
Among the possible factors contributing to this limitation are increased levels of cholecystokinin (CCK).
Positive_regulation (increased) of Gene_expression (levels) of CCK associated with cholecystokinin
2) Confidence 0.50 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9806692 Disease Relevance 0.25 Pain Relevance 1.11
Among the possible factors contributing to this limitation are increased levels of cholecystokinin (CCK).
Positive_regulation (increased) of Gene_expression (levels) of cholecystokinin associated with cholecystokinin
3) Confidence 0.50 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9806692 Disease Relevance 0.25 Pain Relevance 1.11
Effect of critical illness on fasting and nutrient-stimulated CCK concentrations
Positive_regulation (stimulated) of Gene_expression (concentrations) of CCK associated with critical illness and cholecystokinin
4) Confidence 0.48 Published 2006 Journal Crit Care Section Body Doc Link PMC1794491 Disease Relevance 0.31 Pain Relevance 0.20
In CP patients with PEI, lack of serine proteases leads to uninhibited production of CCK, a potent stimulator of pancreatic enzymes.
Positive_regulation (leads) of Gene_expression (production) of CCK associated with cholecystokinin and chronic pancreatitis
5) Confidence 0.16 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 1.80 Pain Relevance 1.73

General Comments

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