INT78329

Context Info Confidence 0.31 First Reported 1998 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 7.57 Pain Relevance 0.73

cytosol (ADC) mitochondrion (ADC) small molecule metabolic process (ADC) lyase activity (ADC) cellular nitrogen compound metabolic process (ADC)

Anatomy Link Frequency Stage 3 1 central nervous system 1 ADC (Homo sapiens)

Pain Link Frequency Relevance Heat Clonidine 2 100.00 Central nervous system 73 99.52 antagonist 5 96.92 Inflammation 7 93.72 palliative 2 91.76 ischemia 25 87.76 anesthesia 5 79.68 ketamine 1 30.56 imagery 20 5.00 intrathecal 11 5.00

Disease Link Frequency Relevance Heat Acquired Immune Deficiency Syndrome Or Hiv Infection 223 100.00 Dementia 9 100.00 Ketoacidosis 121 99.76 Recurrence 32 99.56 Cryptosporidiosis 20 99.42 Pressure And Volume Under Development 64 99.24 Pericardial Effusion 47 98.44 Brain Injury 11 98.44 Cancer 26 97.40 Viral Meningitis 23 94.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The interaction with propranolol, clonidine, phenylephrine, carbachol and tripeptide fMLP which hinder adenylate cyclase (AdC) and activate Ca-polyphosphoinositide (Ca-PPI) signaling system of a cell initiates structural rearrangements similar to acidic transitions.

AdC Binding (interaction) of associated with clonidine

1) Confidence 0.31 Published 1998 Journal Spectrochim Acta A Mol Biomol Spectrosc Section Abstract Doc Link 9807240 Disease Relevance 0 Pain Relevance 0.17

Home characteristics, gender, and presence of rotavirus or of Cryptosporidium (unfortunately, Cryptosporidium data were sparse) showed no association with incidence of ADC.

ADC Neg (no) Binding (association) of associated with cryptosporidiosis

2) Confidence 0.27 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1468406 Disease Relevance 0.99 Pain Relevance 0

Twenty-four of 80 subjects without confounding neurological conditions (30%) were diagnosed with ADC: 13 subjects with ADC Stage 1, 8 subjects with ADC Stage 2, and 3 subjects with ADC Stage 3.

ADC Binding (diagnosed) of in Stage 3

3) Confidence 0.20 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.41 Pain Relevance 0.04

The AIDS dementia complex (ADC) or HIV-associated dementia (HAD) was recognized as a novel central nervous system (CNS) disorder early in the AIDS epidemic [1] and subsequently linked to a pathological substrate of HIV encephalitis (HIVE) [2].

ADC Binding (recognized) of in central nervous system associated with dementia, acquired immune deficiency syndrome or hiv infection, central nervous system and viral meningitis

4) Confidence 0.15 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 1.10 Pain Relevance 0.15

ADC-L was significantly associated with both recurrence and higher survival rate, probably due to a better response to chemotherapy.

ADC-L Binding (associated) of associated with recurrence

5) Confidence 0.09 Published 2010 Journal Cancer Research and Treatment : Official Journal of Korean Cancer Association Section Body Doc Link PMC3021740 Disease Relevance 2.24 Pain Relevance 0.17

In summary, untreated DKA in rats is associated with reduced CBF, as well as with low ADC values indicating CE.

ADC Binding (associated) of associated with pressure and volume under development and ketoacidosis

6) Confidence 0.02 Published 2008 Journal Diabetes Section Body Doc Link PMC2551666 Disease Relevance 2.00 Pain Relevance 0

ADC-1004 binds to, but does not activate, the C5a receptor, thereby acting as an effective antagonist [24].

ADC-1004 Binding (binds) of associated with antagonist

7) Confidence 0.02 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2955599 Disease Relevance 0.83 Pain Relevance 0.20

General Comments

This test has worked.