INT78330

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Context Info
Confidence 0.32
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.19
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (INPP5E) plasma membrane (INPP5E) cytoskeleton (INPP5E)
cilium (INPP5E) biological_process (INPP5E) lipid metabolic process (INPP5E)
INPP5E (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 6 99.70 Very High Very High Very High
Clonidine 4 98.24 Very High Very High Very High
Opioid 3 80.64 Quite High
agonist 2 75.00 Quite High
opioid receptor 2 75.00 Quite High
Neurotransmitter 1 66.08 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 1 77.36 Quite High
Schizophrenia 2 63.12 Quite High
Post-traumatic Stress Disorder 1 52.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine significantly increased PPI without affecting startle reactivity or habituation.
Positive_regulation (increased) of PPI associated with morphine
1) Confidence 0.32 Published 2008 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 18272020 Disease Relevance 0.19 Pain Relevance 0.91
Isoproterenol, yohimbine diphenhydramine, chlorpromazine and atropine, which activate AdC and hinder Ca-PPI, cause conformational changes of HSA similar to basic transitions.
Positive_regulation (activate) of Ca-PPI
2) Confidence 0.03 Published 1998 Journal Spectrochim Acta A Mol Biomol Spectrosc Section Abstract Doc Link 9807240 Disease Relevance 0 Pain Relevance 0.15
The interaction with propranolol, clonidine, phenylephrine, carbachol and tripeptide fMLP which hinder adenylate cyclase (AdC) and activate Ca-polyphosphoinositide (Ca-PPI) signaling system of a cell initiates structural rearrangements similar to acidic transitions.
Positive_regulation (activate) of Ca-PPI associated with clonidine
3) Confidence 0.03 Published 1998 Journal Spectrochim Acta A Mol Biomol Spectrosc Section Abstract Doc Link 9807240 Disease Relevance 0 Pain Relevance 0.16

General Comments

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