INT7834

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 1.90
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde2a) signal transduction (Pde2a) Golgi apparatus (Pde2a)
endoplasmic reticulum (Pde2a) plasma membrane (Pde2a) nucleus (Pde2a)
Anatomy Link Frequency
brain 1
platelets 1
lamina 1
adrenal cortex 1
heart 1
Pde2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 90.48 High High
Spinal cord 7 82.48 Quite High
Dorsal horn 1 78.68 Quite High
substance P 4 73.84 Quite High
Pain 5 71.80 Quite High
Multiple sclerosis 7 71.52 Quite High
Glutamate 12 67.80 Quite High
Neurotransmitter 40 65.56 Quite High
GABAergic 1 60.12 Quite High
Calcitonin gene-related peptide 1 53.92 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 6 99.84 Very High Very High Very High
Reprotox - General 2 14 99.80 Very High Very High Very High
Hypothermia 5 97.84 Very High Very High Very High
Increased Venous Pressure Under Development 10 88.48 High High
Amnesia 3 72.48 Quite High
Pain 3 71.80 Quite High
Demyelinating Disease 7 71.52 Quite High
Pressure And Volume Under Development 7 64.56 Quite High
Cv General 3 Under Development 6 53.04 Quite High
Cognitive Disorder 382 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the mRNA of PDE2, 5, and 9 was observed in all lamina.
Gene_expression (Expression) of PDE2 in lamina
1) Confidence 0.51 Published 2006 Journal J. Chem. Neuroanat. Section Abstract Doc Link 16621445 Disease Relevance 0.09 Pain Relevance 0.45
Inhibitions of cyclic GMP phosphodiesterase and of superoxide production by hypoxia do not seem to participate in the action of hypothermia.
Gene_expression (production) of cyclic GMP phosphodiesterase associated with hypothermia and hypoxia
2) Confidence 0.32 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 12832836 Disease Relevance 1.14 Pain Relevance 0.07
In addition, PDE2 can be found in the brain, heart, adrenal cortex, and platelets (Ito et al. 1996; Martins et al. 1982; Van Staveren et al. 2003).
Gene_expression (found) of PDE2 in platelets
3) Confidence 0.31 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.03
Basal and PGE2-stimulated cAMP production by enterocytes isolated from the small intestine was unaffected by TTX.
Gene_expression (production) of PGE2-stimulated in small intestine
4) Confidence 0.23 Published 1992 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1357143 Disease Relevance 0 Pain Relevance 0.17
It has an IC50 of 0.7 nM for PDE5 with respect to other PDEs (PDE1: 180 nm; PDE2, 3, 4 >1 ?
Gene_expression (has) of PDE2
5) Confidence 0.16 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518390 Disease Relevance 0.67 Pain Relevance 0.20
In addition, PDE2 can be found in the brain, heart, adrenal cortex, and platelets (Ito et al. 1996; Martins et al. 1982; Van Staveren et al. 2003).
Gene_expression (found) of PDE2 in heart
6) Confidence 0.11 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.03
In addition, PDE2 can be found in the brain, heart, adrenal cortex, and platelets (Ito et al. 1996; Martins et al. 1982; Van Staveren et al. 2003).
Gene_expression (found) of PDE2 in brain
7) Confidence 0.11 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.03
In addition, PDE2 can be found in the brain, heart, adrenal cortex, and platelets (Ito et al. 1996; Martins et al. 1982; Van Staveren et al. 2003).
Gene_expression (found) of PDE2 in adrenal cortex
8) Confidence 0.11 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox