INT78348

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.47
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (GAL) Golgi apparatus (GAL) plasma membrane (GALR1)
cellular_component (GAL) response to stress (GAL) cytoplasm (GAL)
Anatomy Link Frequency
brain 1
endocrine system 1
GALR1 (Homo sapiens)
GAL (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 18 100.00 Very High Very High Very High
Pain 8 98.36 Very High Very High Very High
Neurotransmitter 8 96.28 Very High Very High Very High
agonist 7 88.16 High High
alcohol 1 60.64 Quite High
addiction 1 59.20 Quite High
Central nervous system 1 52.56 Quite High
adenocard 1 25.00 Low Low
antagonist 1 25.00 Low Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pathologic Processes 1 100.00 Very High Very High Very High
Neuroendocrine Cancer 2 98.84 Very High Very High Very High
Pain 6 98.36 Very High Very High Very High
Disease 8 92.80 High High
Neurodegenerative Disease 4 90.40 High High
Convulsion 5 89.64 High High
Targeted Disruption 1 82.40 Quite High
Affective Disorder 1 62.64 Quite High
Anxiety Disorder 3 61.36 Quite High
Depression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To evaluate the human galanin receptor 1 as a potential therapeutic target, we fully characterized its interaction with several galanin-like peptides.
galanin receptor 1 Binding (interaction) of galanin
1) Confidence 0.41 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808667 Disease Relevance 0.10 Pain Relevance 0.18
Galanin, a neuropeptide widely expressed in the central and peripheral nervous systems and in the endocrine system, has been shown to regulate numerous physiological and pathological processes through interactions with three G-protein-coupled receptors, GalR1 through GalR3.
GalR1 Binding (interactions) of Galanin in endocrine system associated with pathologic processes and neuropeptide
2) Confidence 0.41 Published 2008 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 18500647 Disease Relevance 0.50 Pain Relevance 0.17
This review will provide an overview of the comprehensive, pharmacological characterization of endogenous and synthetic galanin receptor ligands and their interactions with the galanin receptors, a summary of the various (pleiotropic) biological actions of galanin and GALP (and alarin), and briefly discuss the implications of pathological changes for health and disease and potential clinical therapeutics.
galanin receptor Binding (interactions) of galanin associated with disease
3) Confidence 0.21 Published 2007 Journal Pharmacol. Ther. Section Abstract Doc Link 17604107 Disease Relevance 0.17 Pain Relevance 0.03
The function of galanin

can be exploited through its interaction with three G-protein coupled receptors subtypes such as GalR1, GalR2 and GalR3.

GalR1 Binding (interaction) of galanin
4) Confidence 0.15 Published 2007 Journal Bioinformation Section Abstract Doc Link PMC2248450 Disease Relevance 0.37 Pain Relevance 0.22
Three dimensional modeling of N-terminal region of galanin and its interaction with the galanin receptor


The neuropeptide galanin comes under the powerful and versatile modulators of classical neurotransmitters and is present in brain tissues, which are intimately involved in epileptogenesis.

galanin receptor Binding (interaction) of galanin in brain associated with neurotransmitter and neuropeptide
5) Confidence 0.15 Published 2007 Journal Bioinformation Section Title Doc Link PMC2248450 Disease Relevance 0.33 Pain Relevance 0.21

General Comments

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