INT78352

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Context Info
Confidence 0.68
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.44
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1a) ATPase activity (Abcb1a) plasma membrane (Abcb1a)
transmembrane transport (Abcb1a)
Anatomy Link Frequency
Hepatocytes 2
blood 1
Caco-2 1
fibroblast 1
Abcb1a (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 7 99.18 Very High Very High Very High
Cannabinoid receptor 1 99.02 Very High Very High Very High
antinociception 8 98.12 Very High Very High Very High
Cannabinoid 8 96.70 Very High Very High Very High
Bile 33 90.00 High High
Gabapentin 1 86.00 High High
Lamotrigine 1 83.76 Quite High
carbamazepine 1 82.48 Quite High
Enkephalin 4 75.00 Quite High
Analgesic 3 71.84 Quite High
Disease Link Frequency Relevance Heat
Epilepsy 4 99.00 Very High Very High Very High
Targeted Disruption 45 97.60 Very High Very High Very High
Leukemia 1 96.72 Very High Very High Very High
Cancer 5 86.36 High High
Sprains And Strains 3 80.76 Quite High
Disease 3 76.64 Quite High
Appetite Loss 1 73.28 Quite High
Vomiting 1 72.36 Quite High
Liver Disease 6 52.72 Quite High
Disorder Of Lipid Metabolism 3 23.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The substantial difference in brain tissue EC50 in the absence vs. presence of P-gp suggests that P-gp modulates DPDPE-associated antinociception at sites other than the blood-brain interface.
Localization (presence) of P-gp in blood associated with antinociception
1) Confidence 0.68 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808679 Disease Relevance 0.21 Pain Relevance 0.52
Hepatocytes secrete biliary phospholipids, composed largely of phosphatidylcholine (PC), through multidrug-resistance 2 P-glycoprotein (MDR3, or ABCB4) embedded in the canalicular membrane.
Localization (secrete) of MDR3 in Hepatocytes
2) Confidence 0.61 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.21 Pain Relevance 0.13
MDR3 was shown to translocate PC in a study using mdr2 gene (a murine homolog of h-MDR3) knockout mice.
Localization (translocate) of MDR3 associated with targeted disruption
3) Confidence 0.57 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.23 Pain Relevance 0.13
Hepatocytes secrete biliary phospholipids, composed largely of phosphatidylcholine (PC), through multidrug-resistance 2 P-glycoprotein (MDR3, or ABCB4) embedded in the canalicular membrane.
Localization (secrete) of ABCB4 in Hepatocytes
4) Confidence 0.54 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.21 Pain Relevance 0.13
Unlike the known P-gp inhibitor, PSC833, short 1h exposure to three plant-derived cannabinoids, cannabinol (CBN), cannabidiol (CBD) and Delta(9)-tetrahydrocannabinol (THC) and the synthetic cannabinoid receptor agonist, WIN55, 212-2 (WIN) did not inhibit the efflux of the P-gp substrate Rhodamine 123 (Rh123) in either a drug-selected human T lymphoblastoid leukaemia cell line (CEM/VLB(100)) or in a mouse fibroblast MDR1 transfected cell line (77.1).
Localization (efflux) of P-gp in fibroblast associated with leukemia, cannabinoid receptor, cannabinoid and agonist
5) Confidence 0.21 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16458258 Disease Relevance 0.41 Pain Relevance 0.44
A variety of anti-epileptic drugs (AEDs) were tested for their ability to be transported by P-glycoprotein (P-gp) through Caco-2 monolayers using bi-directional (apical (Ap) to basolateral (Bas), and Bas to Ap) studies.
Localization (transported) of P-gp in Caco-2 associated with epilepsy
6) Confidence 0.08 Published 2006 Journal J Drug Target Section Abstract Doc Link 16882549 Disease Relevance 0.17 Pain Relevance 0.17

General Comments

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