INT78353

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Context Info
Confidence 0.27
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.95
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
macrophages 2
amnion 2
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 3 99.92 Very High Very High Very High
cOX1 1 99.92 Very High Very High Very High
Inflammation 6 99.48 Very High Very High Very High
Nicotine 1 99.24 Very High Very High Very High
cINOD 4 91.16 High High
cytokine 3 86.60 High High
withdrawal 3 80.96 Quite High
aspirin 7 78.96 Quite High
dexamethasone 2 58.68 Quite High
Pain 3 53.04 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 9 99.48 Very High Very High Very High
Nicotine Addiction 2 95.96 Very High Very High Very High
Stress 2 69.36 Quite High
Pain 2 53.04 Quite High
Pre-term Labor 37 5.00 Very Low Very Low Very Low
Infection 11 5.00 Very Low Very Low Very Low
Premature Birth 10 5.00 Very Low Very Low Very Low
Bacterial Vaginosis 6 5.00 Very Low Very Low Very Low
Infant Respiratory Distress Syndrome 4 5.00 Very Low Very Low Very Low
Heart Rate Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of cyclooxygenase-1 by a tobacco carcinogen in U937 human macrophages is correlated to the activation of NF-kappaB.
Positive_regulation (activation) of Positive_regulation (induction) of cyclooxygenase in macrophages associated with cox1
1) Confidence 0.27 Published 2000 Journal Carcinogenesis Section Title Doc Link 10964107 Disease Relevance 0.28 Pain Relevance 0.44
Prostaglandins are generated through two isoforms of the enzyme cyclooxygenase, the constitutively expressed cyclooxygenase (Cox)-1 and Cox-2, which is induced at sites of inflammation.
Positive_regulation (generated) of Positive_regulation (induced) of cyclooxygenase associated with inflammation
2) Confidence 0.20 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808683 Disease Relevance 0.22 Pain Relevance 0.13
Prostaglandins are generated through two isoforms of the enzyme cyclooxygenase, the constitutively expressed cyclooxygenase (Cox)-1 and Cox-2, which is induced at sites of inflammation.
Positive_regulation (generated) of Positive_regulation (induced) of cyclooxygenase associated with inflammation
3) Confidence 0.20 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808683 Disease Relevance 0.22 Pain Relevance 0.13
B transcriptional activity leads to activation of the cyclooxygenase (COX) enzyme in the amnion.
Positive_regulation (leads) of Positive_regulation (activation) of cyclooxygenase in amnion
4) Confidence 0.04 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 0.22 Pain Relevance 0.34

General Comments

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