INT78355

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Context Info
Confidence 0.06
First Reported 1998
Last Reported 2003
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.15
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 4 99.98 Very High Very High Very High
agonist 14 99.72 Very High Very High Very High
Opioid 1 92.56 High High
Kappa opioid receptor 3 90.60 High High
Morphine 1 90.08 High High
cocaine 8 87.88 High High
Nucleus accumbens 1 60.80 Quite High
Dynorphin 1 33.68 Quite Low
opiate 1 25.00 Low Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Bordatella Infection 1 89.44 High High
Glioma 1 56.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of G-protein-coupled opioid receptors inhibits adenylyl cyclase production of cyclic AMP.
Negative_regulation (inhibits) of Gene_expression (production) of cyclase associated with opioid receptor
1) Confidence 0.06 Published 2003 Journal Synapse Section Abstract Doc Link 12422370 Disease Relevance 0 Pain Relevance 0.54
However, we found that only full agonists were able to down-regulate receptor number, G protein activation and adenylyl cyclase inhibition.
Negative_regulation (down-regulate) of Neg (inhibition) Gene_expression (inhibition) of cyclase associated with agonist
2) Confidence 0.03 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808689 Disease Relevance 0.15 Pain Relevance 0.68

General Comments

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