INT78404

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 24
Total Number 26
Disease Relevance 9.73
Pain Relevance 7.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (COX5A) small molecule metabolic process (COX5A)
Anatomy Link Frequency
monocyte 2
blood 1
coronary artery 1
lateral 1
spinal cords 1
COX5A (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 4 100.00 Very High Very High Very High
cINOD 57 99.96 Very High Very High Very High
COX2 16 99.66 Very High Very High Very High
metalloproteinase 8 99.40 Very High Very High Very High
Inflammation 27 99.00 Very High Very High Very High
chemokine 1 98.88 Very High Very High Very High
Pain 9 98.80 Very High Very High Very High
aspirin 12 97.82 Very High Very High Very High
cOX1 12 97.68 Very High Very High Very High
Dismenorea 9 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 4 100.00 Very High Very High Very High
INFLAMMATION 45 99.70 Very High Very High Very High
Stress 3 99.68 Very High Very High Very High
Pain 7 98.80 Very High Very High Very High
Fever 5 98.68 Very High Very High Very High
Coronary Artery Disease 3 98.58 Very High Very High Very High
Adenoma 8 98.32 Very High Very High Very High
Cancer 13 97.90 Very High Very High Very High
Dysmenorrhea 9 97.68 Very High Very High Very High
Pulpitis 2 97.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results reported herein address the questions of what factors are associated with expression (relative messenger RNA levels) of COX-1 and COX-2 in colorectal adenomas and whether there is heterogeneity in the protective effect of NSAIDs by levels of COX expression.
Gene_expression (expression) of COX associated with adenoma and cinod
1) Confidence 0.75 Published 2005 Journal Clin Colorectal Cancer Section Abstract Doc Link 15807932 Disease Relevance 0.59 Pain Relevance 0.25
In contrast, exposure of LPS-stimulated cells to (-)-linalool failed, if not at the highest concentration, both in inhibiting PGE(2) release and in inhibiting increase of inducible cyclooxygenase-2 (COX(2)) expression in the culture medium.
Gene_expression (expression) of COX
2) Confidence 0.75 Published 2006 Journal Life Sci. Section Abstract Doc Link 16137709 Disease Relevance 0.26 Pain Relevance 0.29
We tested for differences in levels of COX expression among selected subgroups of cases using a standard Student t test.
Gene_expression (expression) of COX
3) Confidence 0.75 Published 2005 Journal Clin Colorectal Cancer Section Abstract Doc Link 15807932 Disease Relevance 0.61 Pain Relevance 0.45
The expression of COX enzymes was studied in spinal cords and neuroblastoma cells by western blot.
Gene_expression (expression) of COX in spinal cords
4) Confidence 0.75 Published 2004 Journal Inflamm. Res. Section Body Doc Link 15241564 Disease Relevance 0.08 Pain Relevance 0
The effects of IL-18 on cyclooxygenase (COX)-II gene expression were analysed in peritoneal fluid monocytes and endometriotic cells of endometriosis patients.
Gene_expression (expression) of COX in monocytes
5) Confidence 0.75 Published 2004 Journal Hum. Reprod. Section Body Doc Link 14998974 Disease Relevance 0.09 Pain Relevance 0
Either treatment of ibuprofen or aspirin, that showed no effects on METH-induced hyperthermia, significantly blocked the METH-induced striatal cyclooxygenase (COX) expression.
Gene_expression (expression) of COX associated with aspirin and fever
6) Confidence 0.75 Published 2009 Journal Neurochem. Res. Section Abstract Doc Link 18946735 Disease Relevance 0.41 Pain Relevance 0.25
Five genes were expressed at lower levels in unstable angina samples: anticoagulant protein S, cyclooxygenase (COX)-1, interleukin (IL)-7 and chemokines monocyte chemotactic protein (MCP)-1 and -2.
Gene_expression (expressed) of COX in monocyte associated with chemokine and angina
7) Confidence 0.75 Published 2003 Journal J. Thromb. Haemost. Section Abstract Doc Link 12871422 Disease Relevance 1.01 Pain Relevance 0.45
Expression of cyclooxygenase (COX) proteins was measured using immunoblotting technique.
Gene_expression (Expression) of COX
8) Confidence 0.75 Published 2009 Journal J Med Assoc Thai Section Body Doc Link 19938744 Disease Relevance 0.09 Pain Relevance 0
Western blotting analysis showed expression of both COX isoforms in colon segments, COX-2 levels being 20% higher.
Gene_expression (expression) of COX in colon
9) Confidence 0.75 Published 2001 Journal Medicina (B Aires) Section Abstract Doc Link 11721323 Disease Relevance 0.22 Pain Relevance 0.15
It is now known that the constitutively expressed isoenzyme cyclooxygenase (COX)-1 catalyzes the synthesis of prostanoids that help to regulate normal physiologic processes, including GI mucosa protection, whereas the inducible isoenzyme COX-2 leads to the generation of prostaglandins that mediate inflammation, pain, and fever.
Gene_expression (expressed) of COX associated with pain, inflammation and fever
10) Confidence 0.75 Published 2000 Journal J Rheumatol Suppl Section Abstract Doc Link 11032099 Disease Relevance 0.76 Pain Relevance 0.68
Distribution and expression of cyclooxygenase (COX) isoenzymes, their physiological roles, and the categorization of nonsteroidal anti-inflammatory drugs (NSAIDs).
Gene_expression (expression) of COX associated with inflammation, cinod and cox2
11) Confidence 0.75 Published 1999 Journal Am. J. Med. Section Title Doc Link 10628589 Disease Relevance 0.18 Pain Relevance 0.42
Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism.
Gene_expression (expression) of COX in coronary artery associated with stress, aspirin and coronary artery disease
12) Confidence 0.75 Published 2006 Journal Platelets Section Title Doc Link 16702043 Disease Relevance 0.45 Pain Relevance 0.44
RESULTS: Compared with nonusers of NSAIDs (n = 334), users of cyclooxygenase (COX)-2 inhibitors (n = 40) had decreased knee cartilage defect development in the medial tibiofemoral compartment (odds ratio [OR] 0.4, 95% confidence interval [CI], 0.2-0.99), whereas users of conventional NSAIDs (n = 21) had increased knee cartilage defect development in both medial (OR 3.1, 95% CI, 1.0-9.1) and lateral (OR 2.6, 95% CI, 1.0-6.7) tibiofemoral compartments.
Gene_expression (users) of COX in lateral
13) Confidence 0.65 Published 2009 Journal Am. J. Med. Section Body Doc Link 19699379 Disease Relevance 0 Pain Relevance 0
Here we describe the synthesis of COX/LOX inhibitors which additionally reduce the level of reactive oxygen species, such as hydroxyl radicals which are well known for supporting inflammation processes in Parkinson's disease, Alzheimer's disease and rheumatoid arthritis.
Gene_expression (synthesis) of COX associated with inflammation, rheumatoid arthritis and disease
14) Confidence 0.65 Published 2008 Journal Eur J Med Chem Section Abstract Doc Link 17976864 Disease Relevance 0.56 Pain Relevance 0.23
The targets comprised cyclo-oxygenases 1 & 2 (COX), p38 MAP kinase (p38), c-Jun terminal-NH(2) kinase (JNK) and type 4 cAMP-specific phosphodiesterase (PDE4).
Gene_expression (comprised) of COX
15) Confidence 0.65 Published 2010 Journal Bioorg. Med. Chem. Section Abstract Doc Link 20188577 Disease Relevance 0.09 Pain Relevance 0.04
Non-steroidal anti-inflammatory drugs (NSAID) target the enzyme cyclooxygenase (COX) thus affording relieve from pain, inflammation or fever.
Gene_expression (target) of COX associated with pain, inflammation, cinod and fever
16) Confidence 0.65 Published 2006 Journal Mini Rev Med Chem Section Abstract Doc Link 17168811 Disease Relevance 0.80 Pain Relevance 0.76
Prostaglandins (PG) are synthesized by the sequential action of phosholipases, cyclooxygenases (COX)-1 and COX-2, and specific terminal synthases, and exert their diverse biological effects through several membrane receptors.
Gene_expression (synthesized) of COX
17) Confidence 0.65 Published 2006 Journal Mol. Interv. Section Abstract Doc Link 16565468 Disease Relevance 0.07 Pain Relevance 0.28
We have studied the conformational flexibility of three 5-keto-substituted 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofurans (DHDMBFs) which show dual cyclooxygenase (COX) and 5-lipoxygenase (LOX) inhibition and are potential candidates as antiinflammatory agents and analgesics.
Gene_expression (show) of COX associated with inflammation and analgesic
18) Confidence 0.65 Published 2000 Journal Indian J. Biochem. Biophys. Section Abstract Doc Link 10983419 Disease Relevance 0.10 Pain Relevance 0.10
By inhibiting the COX enzymes and the subsequent production of PGs, NSAIDs not only achieve their desired anti-inflammatory effects but also inhibit the increased production of PGs that is necessary for bone healing to occur.
Gene_expression (production) of COX associated with inflammation and cinod
19) Confidence 0.65 Published 2003 Journal J Clin Pharmacol Section Abstract Doc Link 12953337 Disease Relevance 0.58 Pain Relevance 0.70
This article presents a literature review of the emerging relationship between neoplasia and inflammatory eicosanoids (PGE2 and related prostaglandins), with a focus on how inhibition of their synthesizing oxidases, particularly cyclooxygenase (COX), offers anticancer actions in vitro and in vivo.
Gene_expression (synthesizing) of COX associated with inflammation and cancer
20) Confidence 0.65 Published 2002 Journal Integr Cancer Ther Section Abstract Doc Link 14664746 Disease Relevance 1.09 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox