INT7841

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 17
Disease Relevance 7.63
Pain Relevance 4.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tspo) aging (Tspo) response to stress (Tspo)
Anatomy Link Frequency
neurons 2
brain 2
microglia 2
immune cells 1
sciatic nerve 1
Tspo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 72 100.00 Very High Very High Very High
gABA 4 100.00 Very High Very High Very High
Analgesic 2 100.00 Very High Very High Very High
positron emission tomography 416 99.76 Very High Very High Very High
Spinal cord 7 99.76 Very High Very High Very High
dorsal root ganglion 55 99.72 Very High Very High Very High
agonist 52 99.64 Very High Very High Very High
Sciatic nerve 23 99.54 Very High Very High Very High
Dorsal horn 6 99.00 Very High Very High Very High
Antinociceptive 6 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 55 99.72 Very High Very High Very High
Injury 54 98.28 Very High Very High Very High
Herpes Simplex Encephalitis 328 92.32 High High
Neurological Disease 88 88.08 High High
Pain 1 87.00 High High
Nociception 1 84.56 Quite High
Disease 48 83.32 Quite High
Demyelinating Disease 16 79.80 Quite High
Stroke 16 78.76 Quite High
Body Weight 9 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We now show expression of both PBR mRNA and protein, and the appearance of binding of a synthetic ligand, [(3)H]PK11195, in dorsal root ganglion (DRG) neurons following injury to the sciatic nerve.
Gene_expression (expression) of PBR mRNA in sciatic nerve associated with ganglion cysts, dorsal root ganglion, injury and sciatic nerve
1) Confidence 0.75 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15255978 Disease Relevance 0.69 Pain Relevance 0.34
The PBR expression in the DRG is restricted to small and medium-sized neurons and returns to naïve levels if the injured peripheral axons are allowed to regrow and reinnervate targets.
Gene_expression (xpression ) of PBR in DRG associated with dorsal root ganglion
2) Confidence 0.75 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15255978 Disease Relevance 0.87 Pain Relevance 0.48
PBR expression in the nervous system has been reported in non-neuronal glial and immune cells.
Gene_expression (expression) of PBR in immune cells
3) Confidence 0.75 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15255978 Disease Relevance 0.56 Pain Relevance 0.22
The activation of microglia cells is accompanied by an increased expression of the translocator protein (TSPO), an 18 kDa component of a heteromeric complex.
Gene_expression (expression) of TSPO in microglia
4) Confidence 0.74 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.84 Pain Relevance 0.29
In contrast to [11C]-(R)-PK11195, [11C]-DPA-713 is even able to show specific binding to the low basal expression levels of TSPO in control rats.
Gene_expression (expression) of TSPO
5) Confidence 0.74 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.15 Pain Relevance 0
The expression of the TSPO is low in the healthy brain, but is highly upregulated in neuroinflammation.
Gene_expression (expression) of TSPO in brain
6) Confidence 0.74 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.70 Pain Relevance 0.29
In addition, the greater slope of the correlation between tracer uptake and TSPO expression (Fig. 4) suggests that [11C]-DPA-713 is more sensitive for small changes in the amount of TSPO as compared to [11C]-(R)-PK11195.
Gene_expression (expression) of TSPO
7) Confidence 0.74 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.14 Pain Relevance 0
The activation of microglia cells is accompanied by an increased expression of the translocator protein (TSPO), an 18 kDa component of a heteromeric complex.
Gene_expression (expression) of translocator protein in microglia
8) Confidence 0.74 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.84 Pain Relevance 0.28
No non-neuronal PBR expression is detected, unlike its putative endogenous ligand the diazepam binding inhibitor (DBI), which is expressed only in non-neuronal cells, including the satellite cells that surround DRG neurons.
Gene_expression (expression) of PBR in neurons associated with dorsal root ganglion
9) Confidence 0.65 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15255978 Disease Relevance 0.83 Pain Relevance 0.46
Three days after sciatic nerve transection, however, PBR mRNA begins to be expressed in injured neurons, and 4 weeks after the injury, expression and ligand binding are present in 35% of L4 DRG neurons.
Gene_expression (expressed) of PBR mRNA in neurons associated with dorsal root ganglion, injury and sciatic nerve
10) Confidence 0.65 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15255978 Disease Relevance 0.86 Pain Relevance 0.44
The present results showed that [11C]-DPA-713 is a promising new radioligand for TSPO expression in activated microglia due to its low non-specific binding in the brain.
Gene_expression (expression) of TSPO in brain
11) Confidence 0.57 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.13 Pain Relevance 0.06
This tracer appears to be a more sensitive tool to detect small changes in TSPO expression than [11C]-(R)-PK11195.
Gene_expression (expression) of TSPO
12) Confidence 0.57 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.14 Pain Relevance 0.13
Therefore, a more sensitive and specific PET tracer for TSPO imaging would be of great interest.
Gene_expression (imaging) of TSPO associated with positron emission tomography and imagery
13) Confidence 0.56 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2763079 Disease Relevance 0.47 Pain Relevance 0.38
Participation of the GABA/benzodiazepine receptor and the NO-cyclicGMP pathway in the "antinociceptive-like effects" of diazepam.
Gene_expression (Participation) of GABA/benzodiazepine receptor associated with gaba, analgesic and antinociceptive
14) Confidence 0.44 Published 2008 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 18638499 Disease Relevance 0.17 Pain Relevance 0.61
The ability of alpha 2-adrenergic receptor antagonists to mimic the FG 7142 cue suggests that activation of the noradrenergic system may underlie cues produced by benzodiazepine receptor inverse agonists.
Gene_expression (produced) of benzodiazepine receptor associated with antagonist and agonist
15) Confidence 0.19 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1357678 Disease Relevance 0 Pain Relevance 0.23
Of the genes listed in Table 4, seven were found in both studies (Peripheral Benzodiazepine receptor, 5HT3, Gadd45, CLP36, Lysozyme, SNAP25 and VGF).
Gene_expression (found) of Benzodiazepine receptor
16) Confidence 0.08 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC139981 Disease Relevance 0.17 Pain Relevance 0.21
This disruption of steroidogenesis by salicylate corresponded to a significant drop in the gene expression of StAR and PBR, but not P450scc or 11beta-hydroxylase, compared to the sham-treated fish.
Gene_expression (expression) of PBR
17) Confidence 0.08 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16551645 Disease Relevance 0.08 Pain Relevance 0.04

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