INT7842

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Context Info
Confidence 0.67
First Reported 1981
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 1.99
Pain Relevance 6.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adra1a) plasma membrane (Adra1a) cellular_component (Adra1a)
response to stress (Adra1a) signal transducer activity (Adra1a)
Anatomy Link Frequency
nucleus 3
blood 1
artery 1
chromaffin cells 1
astrocytes 1
Adra1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 14 100.00 Very High Very High Very High
monoamine 3 100.00 Very High Very High Very High
Clonidine 30 99.98 Very High Very High Very High
agonist 13 99.96 Very High Very High Very High
Hyperalgesia 8 99.84 Very High Very High Very High
Potency 3 99.72 Very High Very High Very High
noradrenaline 32 99.08 Very High Very High Very High
Dopamine 2 97.96 Very High Very High Very High
Cholecystokinin 4 95.04 Very High Very High Very High
depression 2 94.88 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 9 99.84 Very High Very High Very High
Stress 8 95.08 Very High Very High Very High
Depression 2 94.88 High High
Bordatella Infection 1 92.72 High High
Schizophrenia 1 91.32 High High
Pain 4 88.16 High High
Peripheral Neuropathy 1 84.96 Quite High
Neuropathic Pain 1 75.00 Quite High
Heart Rate Under Development 4 74.16 Quite High
Frailty 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Different types of neuroleptics were studied for pre- and postsynaptic alpha-adrenoceptor antagonism in pithed rats using the blood pressure effect of clonidine as a measure of postsynaptic alpha-adrenoceptor activation and the depression of the heart rate response to electrical stimulation as a measure of presynaptic alpha-adrenoceptor activation.
Gene_expression (antagonism) of alpha-adrenoceptor in blood associated with depression and clonidine
1) Confidence 0.67 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6113964 Disease Relevance 0.09 Pain Relevance 0.21
Injection of the non-specific alpha-adrenergic blocker phentolamine and the alpha 2-adrenergic blocker yohimbine significantly relieved the hyperalgesia, while injection of the alpha 1-adrenergic blocker prazosin had no effect.
Gene_expression (injection) of alpha 1-adrenergic associated with hyperalgesia
2) Confidence 0.62 Published 1995 Journal Pain Section Abstract Doc Link 7596628 Disease Relevance 1.01 Pain Relevance 1.21
Whether a similar profile is produced by alpha 1-adrenoceptor agonists such as PPA has not previously been explored.
Gene_expression (produced) of 1-adrenoceptor associated with agonist
3) Confidence 0.52 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1357700 Disease Relevance 0 Pain Relevance 0.45
In order to describe the alpha-1 adrenoceptor subtypes involved in this action, the effect of phenylephrine was also investigated after pretreatment of the cells with various antagonists.
Gene_expression (describe) of alpha-1 adrenoceptor associated with antagonist
4) Confidence 0.46 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1682485 Disease Relevance 0 Pain Relevance 0.19
In contrast to an alpha 2-adrenergic mediated inhibition of the flexor reflex in intact rats, clonidine produced an alpha 1-adrenergic mediated increase in flexor reflex amplitude in spinalized rats.
Gene_expression (produced) of alpha 1-adrenergic associated with clonidine
5) Confidence 0.43 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 2861260 Disease Relevance 0.09 Pain Relevance 0.88
In pithed rats, the cumulative dose-pressor response curves elicited by the relatively selective alpha-2 adrenoceptor agonists, B-HT 930 and M-7, were depressed by urethane significantly more than those produced by the relatively selective alpha-1 adrenoceptor agonists, phenylephrine and cirazoline, or by angiotensin II.
Gene_expression (produced) of alpha-1 adrenoceptor in M-7 associated with agonist
6) Confidence 0.41 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6127404 Disease Relevance 0.07 Pain Relevance 0.56
Thus, in late pregnancy, there is reduced noradrenergic input to the paraventricular nucleus and reduced alpha1A-receptor expression in the paraventricular nucleus, both of which may contribute to the reduced responsiveness of the HPA axis in pregnancy.
Gene_expression (expression) of alpha1A-receptor in nucleus
7) Confidence 0.24 Published 2005 Journal J. Neuroendocrinol. Section Abstract Doc Link 15720474 Disease Relevance 0.22 Pain Relevance 0.35
At 96 h after the administration of picrotoxin into the basolateral nucleus, we have observed an increase in the expression of genes associated with 18 different monoamine (ie adrenergic alpha 1, alpha 2 and beta 2, serotonergic 5HT5b and 5HT6, dopamine D4 and muscarinic m1, m2 and m3) and peptide (CCK A and B, angiotensin 1A, mu and kappa opiate, FSH, TSH, LH, GNRH, and neuropeptide Y) G-protein coupled receptors (GPCRs).
Gene_expression (expression) of adrenergic alpha 1 in nucleus associated with dopamine, neuropeptide, opiate and monoamine
8) Confidence 0.24 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15170462 Disease Relevance 0.09 Pain Relevance 0.35
In virgin rats, benoxathian increased basal and stress-induced ACTH secretion, but in late pregnant rats the benoxathian effects were attenuated, indicating reduced sensitivity of the HPA axis to noradrenaline neurotransmission and/or the inability of the system to become disinhibited at this time. alpha1A-adrenoreceptor mRNA expression in the parvocellular and magnocellular paraventricular nucleus, measured by in situ hybridisation, was decreased in late pregnant compared to virgin rats.
Gene_expression (expression) of alpha1A-adrenoreceptor in nucleus associated with stress and noradrenaline
9) Confidence 0.20 Published 2005 Journal J. Neuroendocrinol. Section Abstract Doc Link 15720474 Disease Relevance 0.32 Pain Relevance 0.43
However, the greater inhibitory effects of SKF in THAP-pretreated tissues, probably reflected the mobilisation of VOCCs by NA following THAP exposure, because SKF was shown separately to block VOCC-mediated contractions in tissues depolarised with 100 mM KCl alone. 10 microM niflumic acid, an inhibitor of Ca2+(-activated) Cl- channels, did not affect responses to NA in 4.7 mM or 14.7 mM KC1, suggesting that VOCC opening induced by NA in 14.7 mM KCl was not due to depolarisation produced by alpha 1-adrenoceptor induced Cl- efflux.
Gene_expression (produced) of 1-adrenoceptor associated with noradrenaline
10) Confidence 0.19 Published 1998 Journal Pharmacol. Res. Section Abstract Doc Link 9695117 Disease Relevance 0.09 Pain Relevance 0.52
The analysis shows that the two cell populations differ in the gene expression of two different types of 5-HT receptors and an alpha-1 adrenoreceptor (Ada1d).
Gene_expression (expression) of alpha-1 adrenoreceptor
11) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566599 Disease Relevance 0 Pain Relevance 0.21
Furthermore, [Ca2+]i responses evoked by phenylephrine (10(-5) M) were blocked by prazosin (0.2x10(-6) M), suggesting the expression of alpha1-adrenergic receptors on the acutely isolated astrocytes.
Gene_expression (expression) of alpha1-adrenergic in astrocytes
12) Confidence 0.08 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9819144 Disease Relevance 0 Pain Relevance 0.66
The potency of different alpha 1-adrenoceptor antagonists tested in the rabbit prostate was significantly correlated with their binding affinity for the expressed recombinant alpha 1A-, but not alpha 1B- or alpha 1D-, adrenoceptor subtype, whereas, the potency of the alpha 1-adrenoceptor antagonists tested in the rabbit hypogastric artery was better correlated with the defined alpha 1D-adrenoceptor.
Gene_expression (expressed) of alpha 1-adrenoceptor in artery associated with antagonist and potency
13) Confidence 0.07 Published 1996 Journal Acta Physiol. Scand. Section Abstract Doc Link 8931767 Disease Relevance 0 Pain Relevance 0.28
Direct and remote modulation of L-channels in chromaffin cells: distinct actions on alpha1C and alpha1D subunits?
Gene_expression (actions) of alpha1C in chromaffin cells
14) Confidence 0.04 Published 2004 Journal Mol. Neurobiol. Section Title Doc Link 15034224 Disease Relevance 0 Pain Relevance 0.11

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