INT78429

Context Info Confidence 0.44 First Reported 1997 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 11 Total Number 12 Disease Relevance 4.60 Pain Relevance 2.10

Anatomy Link Frequency liver 1 PSP 1 kidney 1 TRGC1 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 7 99.84 spinal inflammation 23 97.08 endometriosis 12 93.44 local anesthetic 2 91.88 Sumatriptan 6 85.96 Clonidine 7 84.84 analgesia 3 75.00 epidural 2 75.00 headache 8 74.64 abdominal pain 10 72.16

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 7 99.84 Shellfish Poisoning 11 99.28 Graft Vs Host Disease 6 99.28 Lymphatic System Cancer 8 98.78 Pressure And Volume Under Development 165 98.76 Angioedema 27 98.36 Low Back Pain 23 97.08 Lymphoproliferative Disease 4 96.76 Endometriosis (extended) 13 93.44 Hereditary Angioedema 157 91.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although not directly comparable, response time seems similar to that reported for C1 inhibitor treatment, although recurrent angioedema seems to be less frequent with C1 inhibitor.18,19 Multiple attacks

Positive_regulation (reported) of C1 associated with angioedema

1) Confidence 0.44 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941790 Disease Relevance 0.19 Pain Relevance 0

The attenuated androgens, such as danazol, increase C1 inhibitor via the liver and carry the risk of long-term side effects[31].

Positive_regulation (increase) of C1 in liver

2) Confidence 0.43 Published 2010 Journal BMC Blood Disord Section Body Doc Link PMC2881905 Disease Relevance 0.85 Pain Relevance 0.15

Capacity of lymphoma cells to deplete C1-INH or to cause its consumption through C1 activation, and the possibility to treat AAE by curing the underlying lymphoma, linked the lymphoproliferative disease to the pathogenesis of AAE [1,11-15].

Positive_regulation (activation) of C1 associated with pressure and volume under development, lymphatic system cancer and lymphoproliferative disease

3) Confidence 0.14 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2925362 Disease Relevance 1.80 Pain Relevance 0.05

In this case the surface patch generated as a solution to the fourth order PDE contains the boundary curves c1 and c4 whilst it does not necessarily contain the curves c2 and c3.

Positive_regulation (curves) of c1

4) Confidence 0.14 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1198260 Disease Relevance 0 Pain Relevance 0

c derives_from c1 - a primitive relation involving two distinct material continuants c and c1

Positive_regulation (derives_from) of c1

5) Confidence 0.11 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175958 Disease Relevance 0 Pain Relevance 0

Thus C1 frequencies were increased in RA and kidney graft rejection, whereas those of C2 were increased in AS, and kidney rejection.

Positive_regulation (increased) of C1 in kidney associated with spinal inflammation, rheumatoid arthritis and graft vs host disease

6) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928722 Disease Relevance 1.12 Pain Relevance 0.47

C1-inhibitor regulates the activity of the first component of the complement system, C1-esterase, controlling both C1's rate of activation, as well as deactivating activated C1.

Positive_regulation (activated) of C1

7) Confidence 0.05 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.55 Pain Relevance 0

C1INH regulates activation of the classical complement pathway by inactivating the protease function of activated C1 complex.

Positive_regulation (activated) of C1

8) Confidence 0.05 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0 Pain Relevance 0

It also prevents spontaneous activation of C1 and binding to the zymogen forms of C1r and C1s [24].

Positive_regulation (activation) of C1

9) Confidence 0.05 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0 Pain Relevance 0

The ERK1/2 response was abolished completely when C1 incubation time was increased from 6 to 21 h (Fig. 4).

Positive_regulation (increased) of C1

10) Confidence 0.04 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513146 Disease Relevance 0 Pain Relevance 0

Gessner et al. investigated serum and urine in human PSP victims and detected a significant increase of the PST C1 in comparison to GTX2, which is distinguished by an additional sulfate on the carbamoyl side group [122].

Positive_regulation (increase) of C1 in PSP associated with shellfish poisoning

11) Confidence 0.04 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.10 Pain Relevance 0

A obvious reduction of MAP appeared in the groups of C1 and C2, but in the other groups the hemodynamical parameters were stable.

Spec (appeared) Positive_regulation (groups) of C1

12) Confidence 0.03 Published 1997 Journal J. Tongji Med. Univ. Section Abstract Doc Link 9812772 Disease Relevance 0 Pain Relevance 1.43

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